公开(公告)号：EP3936188A1

公开(公告)日：2022-01-12

申请号：EP21186914.4

申请日：2016-04-20

申请人： University of Washington

发明人： MACLELLAN, W. Robb ,  EL-NACHEF, Danny

IPC分类号： A61P9/02 ,  A61P21/00 ,  C12N15/07 ,  C12N15/54 ,  C12N15/63 ,  A61K38/44 ,  C12N9/00

摘要： An expression vector capable of disrupting the silencing of cell cycle genes in adult cells, such as adult cardiac myocytes and other quiescent cells in terminally differentiated tissues, comprising: (a) a nucleic acid sequence encoding lysine-specific demethylase 4D (KDM4D); (b) a promoter that induces or effects overexpression of KDM4D, wherein the promoter is operably linked to the nucleic acid sequence; and (c) a regulatory element that inducibly represses the overexpression of KDM4D. The vector can be administered to a subject in a method for inducing tissue-specific hyperplasia in a mammal, including cardiomyocyte proliferation. The method provides for regenerative therapy, including improving cardiac function after myocardial infarct and other forms of cardiac damage.

公开(公告)号：EP3935178A1

公开(公告)日：2022-01-12

申请号：EP20765987.1

申请日：2020-03-06

申请人： Inmed Pharmaceuticals Inc.

发明人： YADAV, Vikramaditya G. ,  ROY, Protiva ,  AYAKAR, Sonal ,  CHANG, Benson ,  HSU, Eric

IPC分类号： C12N15/63 ,  C12N1/21 ,  C12N15/31 ,  C12N15/52 ,  C12N15/54 ,  C12P1/00 ,  C12P17/02 ,  C12P7/00

公开(公告)号：EP3901272A1

公开(公告)日：2021-10-27

申请号：EP19899302.4

申请日：2019-12-17

申请人： Teijin Limited ,  Synart Co., Ltd.

发明人： SHOJI, Shinichiro ,  ISHII, Jun ,  KONDO, Akihiko ,  WATANABE, Hidekazu ,  KANOU, Masanobu ,  NAKAJIMA, Ryota

IPC分类号： C12P19/30 ,  C12P19/32 ,  C12P19/36 ,  C12N1/19 ,  C12N1/21 ,  C12N15/53 ,  C12N15/54 ,  C12N15/56 ,  C12N15/61 ,  C12N15/70 ,  C12N15/81

摘要： Provided is a technique for synthesizing a nicotinamide derivative (NAm derivative) such as a nicotinamide mononucleotide (NMN) with high efficiency. A genetically modified microorganism is used, which can express, as nicotinamide phosphoribosylt ransferase (NAMPT), NAMPT having a conversion efficiency of 5-folds or more th at of human NAMPT.

公开(公告)号：EP3872181A1

公开(公告)日：2021-09-01

申请号：EP19877208.9

申请日：2019-10-24

申请人： School Corporation, Azabu Veterinary Medicine Educational Institution ,  Tella, Inc.

发明人： YAMASHITA, Tadashi ,  NAGANE, Masaki ,  IKEDA, Teruo ,  MIYATAKE, Shoichiro ,  OKAMOTO, Mariko

IPC分类号： C12N15/54 ,  A61K35/17 ,  A61K45/00 ,  A61P35/00 ,  A61P43/00 ,  C12N5/0783 ,  C12N5/10 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/50 ,  C12N9/10

摘要： The prevent invention provides an activated T cell in which the expression of an immune checkpoint molecule is suppressed, a method for producing the T cell, and a method for screening for a substance that can be used in the production of the T cell. Specifically, the prevent invention includes, as solving means, a method for producing or inducing a T cell in which the expression of an immune checkpoint molecule is not induced, the method comprising reducing or losing the function of UDP-glucose ceramide glucosyltransferase (UGCG) or ganglioside in a T cell, and a T cell produced or induced by the aforementioned method.

公开(公告)号：EP3844281A1

公开(公告)日：2021-07-07

申请号：EP18932124.3

申请日：2018-08-29

申请人： United Biopharma Inc

发明人： PENG, Wen-Jiun ,  CHEN, Hui-Jung

IPC分类号： C12N15/53 ,  C12N15/54 ,  C12N9/10 ,  C12P21/00

公开(公告)号：EP3227441B1

公开(公告)日：2021-06-30

申请号：EP15864736.2

申请日：2015-12-01

发明人： PENN, Marc, S. ,  KIEDROWSKI, Matthew ,  MAYORGA, Maritza

IPC分类号： C12N9/12 ,  C12N15/54 ,  A61K38/17 ,  A61P29/00 ,  A61P9/10 ,  A61K35/28

公开(公告)号：EP3835410A1

公开(公告)日：2021-06-16

申请号：EP19848560.9

申请日：2019-08-09

申请人： Kyowa Hakko Bio Co., Ltd.

发明人： DAIRI Tohru ,  SATOH Yasuharu ,  HAYASHI Shohei ,  NAKA Mai ,  UJIHARA Tetsuro

IPC分类号： C12N1/11 ,  C12N1/13 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12P7/64 ,  C12N15/30 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12N15/63 ,  C12R1/90

摘要： An object of the present invention is to provide a microorganism that efficiently produces EPA and a method for producing EPA using the microorganism. The present invention relates to a microorganism having an ability to produce docosahexaenoic acid (DHA), wherein the microorganism contains a protein composed of an amino acid sequence in which at least one of the amino acid residues at positions 6, 65, 230, 231, and 275 in the amino acid sequence represented by SEQ ID NO: 2 has been substituted with another amino acid residue (mutated OrfB), and is capable of producing eicosapentaenoic acid (EPA), and the like.

公开(公告)号：EP3445406B1

公开(公告)日：2021-05-26

申请号：EP17786662.1

申请日：2017-04-20

发明人： SEGOVIA, Jose C. ,  GOMEZ, Maria G. ,  NAVARRO, Susana ,  MEZA, Nestor ,  BUEREN, Juan ,  BRAVO, Maria G.

IPC分类号： A61K48/00 ,  C12N15/79 ,  C12N15/54

公开(公告)号：EP3822349A1

公开(公告)日：2021-05-19

申请号：EP19833322.1

申请日：2019-07-03

申请人： Takara Bio Inc.

发明人： UEMORI, Takashi ,  MATSUMOTO, Hiroyuki ,  SAITO, Kensuke ,  AKITOMO, Miwa

IPC分类号： C12N9/12 ,  C12N15/54

摘要： Provided are: a DNA polymerase mutant having reverse transcriptase activity, the DNA polymerase mutant including a sequence consisting of twelve specific amino acids A1-A12, wherein the DNA polymerase mutant having reverse transcriptase activity is characterized in that the A3 and/or A10 amino acid is substituted by a basic amino acid residue different from that prior to the introduction of mutation; a kit and a composition including the DNA polymerase; a method for producing the DNA polymerase; and a method for modifying an existing DNA polymerase having reverse transcriptase activity.

公开(公告)号：EP3620528B1

公开(公告)日：2021-04-14

申请号：EP19190857.3

申请日：2014-12-12

发明人： WANG, Fengqing ,  WEI, Dongzhi ,  XU, Liqin ,  LIU, Haohao ,  LIU, Xinbin ,  CHEN, Nenghui

IPC分类号： C12P33/00 ,  C12P33/02 ,  C12N15/53 ,  C12N15/54 ,  C12N9/04 ,  C12N9/10 ,  C12R1/32 ,  C12N1/21