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    Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same
    22.
    发明公开
    Hybrid streptokinases with fibrin binding domains and methods for the synthesis of same 失效
    Hybride Streptokinasen mitFibrinbindungsdomänenund Verfahren zu deren Synthese。

    公开(公告)号：EP0397366A1

    公开(公告)日：1990-11-14

    申请号：EP90304710.8

    申请日：1990-05-01

    申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA

    发明人： Malke, Horst ,  Ferretti, Joseph J.

    IPC分类号： C12N15/58 ,  C12N1/21 ,  C12N9/70 ,  C12N15/62

    CPC分类号： C12N9/6435 ,  C07K14/3153 ,  C07K2319/00 ,  C12Y304/21007

    摘要： Compositions and methods for the synthesis of hybrid streptokinase with fibrin binding domains based on gene fusion technology. Recombinant DNA methods have been used to fuse gene segments for streptokinase and for fibrin-binding domains and express the fused gene in prokaryotic microorganisms, and the respective expressed protein is subsequently obtained by biotechnologic fermentation for the purpose of use in clinical medicine.

    摘要翻译： 基于基因融合技术合成具有纤维蛋白结合结构域的杂交链激酶的组合物和方法。 已经使用重组DNA方法融合链激酶和纤维蛋白结合结构域的基因片段，并在原核微生物中表达融合基因，随后通过生物技术发酵获得各自表达的蛋白质，用于临床医学中。

    VACCINES BASED ON STREPTOKINASE
    28.
    发明授权
    VACCINES BASED ON STREPTOKINASE 失效
    疫苗 - 基于链激酶

    公开(公告)号：EP0623170B1

    公开(公告)日：2001-05-23

    申请号：EP93902409.7

    申请日：1993-01-18

    申请人： PFIZER INC.

    发明人： LEIGH, James Andrew

    IPC分类号： C12N15/58 ,  C12N9/70 ,  C12P21/08 ,  A01K67/027 ,  A61K39/09 ,  A61K39/085

    CPC分类号： A61K39/085 ,  A61K39/00 ,  C07K14/3153 ,  C07K16/40

    摘要： A vaccine for use to treat or prevent a disease in a vertebrate, the vaccine comprising an antigenic entity and a carrier, the antigenic entity being adapted to cause, following vaccination of the vertebrate with the vaccine, an immune response providing antibodies which inhibit a factor from a pathogen which directly or indirectly causes breakdown of protein in the vertebrate wherein said breakdown enhances growth of the pathogen. A vaccine against the streptokinase of Streptococcus uberis can be used to prevent mastitis in cattle.

    Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said proteins
    30.
    发明公开
    Clot-specific streptokinase proteins possessing altered plasminogen activation characteristics and a process for the preparation of said proteins 有权
    Koagulationsspezifische链激酶具有改变的纤维蛋白溶酶原激活的属性和它们的制备方法

    公开(公告)号：EP1024192A2

    公开(公告)日：2000-08-02

    申请号：EP99310541.0

    申请日：1999-12-23

    申请人： Council of Scientific and Industrial Research

    发明人： Sahni, Girish ,  Kumar, Rajesh ,  Roy, Chaiti ,  Rajogopal, Kammara ,  Nihalani, Deepak ,  Sundaram, Vasudha ,  Yadav, Mahavir

    IPC分类号： C12N15/58 ,  C12N15/62 ,  C12N9/70 ,  C12N5/10 ,  C07K19/00 ,  C07K14/745 ,  A61K38/36

    CPC分类号： C07K14/78 ,  A61K38/00 ,  C07K14/3153 ,  C07K19/00 ,  C07K2319/70

    摘要： The present invention relates to a hybrid plasminogen activator comprising a polypeptide bond union between streptokinase (SK), or modified forms of SK, or suitable parts thereof, which are capable of plasminogen (PG) activation, with fibrin binding regions of human fibronectin selected from the pair of fibrin binding domains 4 and 5, or domains 1 and 2, or modified forms thereof, to achieve various motifs for joining the fibrin binding domains with streptokinase or its modified forms, so that the hybrid plasminogen activator possesses the ability to bind with fibrin independently and also characteristically retains a plasminogen activation ability which becomes evident only after a pronounced duration, or lag, after exposure of the plasminogen activator to a suitable animal or human plasminogen; a method of producing the hybrid plasminogen activator and formulation comprising the said activator.

    摘要翻译： 本发明涉及一种混合纤溶酶原激活剂包括链激酶（SK）之间的多肽键联合，或修饰的SK的形式，或适合的零件，其能够纤溶酶原（PG）的活化，以从选定的人纤连蛋白的血纤蛋白结合区 所述一对血纤蛋白结合结构域4和5，或结构域1和2，或其修饰形式，以实现接合的血纤蛋白结合与链激酶或其修饰的形式域的各种基序的，所以没有混合纤溶酶原激活剂具有与结合的能力 纤维蛋白unabhängig等特征性地保留哪些仅后的显着的持续时间变得明显纤溶酶原活化能力，或者是，所述纤溶酶原激活剂的曝光到合适的动物或人后纤溶酶原; 生产混合纤溶酶原激活剂和配制剂包含所述活化剂的一种方法。