公开(公告)号：EP4126910A1

公开(公告)日：2023-02-08

申请号：EP21720360.3

申请日：2021-03-31

申请人： Voyager Therapeutics, Inc.

发明人： NONNENMACHER, Mathieu E. ,  HOU, Jinzhao ,  WANG, Wei ,  CHILD, Matthew

IPC分类号： C07K14/005 ,  C12N15/10 ,  C12N15/86 ,  C40B30/06

公开(公告)号：EP3230498B1

公开(公告)日：2023-01-18

申请号：EP15868101.5

申请日：2015-12-08

发明人： AYERS, Mark, D. ,  LOBODA, Andrey ,  LUNCEFORD, Jared, K. ,  MCCLANAHAN, Terrill, K. ,  MURPHY, Erin, E. ,  NEBOZHYN, Michael

IPC分类号： C40B30/04 ,  A61K39/00 ,  A61K39/395

公开(公告)号：EP4115911A1

公开(公告)日：2023-01-11

申请号：EP22178430.9

申请日：2011-04-29

申请人： Janssen Biotech, Inc.

发明人： JACOBS, Steven

IPC分类号： A61K49/00 ,  C07K14/00 ,  C40B50/00 ,  C40B40/08 ,  C40B40/02 ,  C40B30/04 ,  C07H21/00 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61K38/16 ,  A61P25/00 ,  A61K38/22 ,  A61P7/00 ,  A61P27/02 ,  A61P35/00 ,  A61P9/00

摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof. The protein scaffold molecules of the present invention exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：EP4105657A1

公开(公告)日：2022-12-21

申请号：EP22176536.5

申请日：2014-01-16

申请人： Astute Medical, Inc.

发明人： NAKAMURA, Kevin ,  GRAY, Jeff ,  ANDERBERG, Joseph ,  MCPHERSON, Paul ,  KAMPF, James Patrick

IPC分类号： G01N33/566 ,  C12M1/34 ,  C40B30/04 ,  C40B60/12 ,  G01N33/573

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.

公开(公告)号：EP4038391A1

公开(公告)日：2022-08-10

申请号：EP20789683.8

申请日：2020-09-30

申请人： AC Immune SA

发明人： GRASSO, Luigino

IPC分类号： G01N33/60 ,  G01N33/68 ,  C40B50/00 ,  C40B30/04

公开(公告)号：EP4029024A1

公开(公告)日：2022-07-20

申请号：EP20767855.8

申请日：2020-09-11

申请人： HTE GmbH The High Throughput Experimentation Company

发明人： LEJKOWSKI, Michael Ludwig ,  KRAEMER, Michael ,  SAUER, Tilman ,  STRASSER, Andreas ,  RUPP, Benjamin

IPC分类号： G16C20/10 ,  G16C20/70 ,  G16C20/90 ,  G16C60/00 ,  B01J19/00 ,  C40B30/08 ,  G16C20/30 ,  G06N3/00

公开(公告)号：EP4004200A1

公开(公告)日：2022-06-01

申请号：EP20863365.1

申请日：2020-09-11

申请人： The University of Chicago

发明人： RANGANATHAN, Rama ,  FERGUSON, Andrew

IPC分类号： C12N15/00 ,  C12N15/09 ,  C12N15/10 ,  C40B10/00 ,  C40B30/00 ,  C40B40/06

公开(公告)号：EP3927869A1

公开(公告)日：2021-12-29

申请号：EP20758985.4

申请日：2020-02-20

申请人： Stratos Genomics, Inc.

发明人： CHANDRASEKAR, Jagadeeswaran ,  KOKORIS, Mark Stamatios ,  AGUIRRE, Gerson ,  TABONE, John ,  MCRUER, Robert N. ,  LEE, Michael ,  CORNING, Matthew ,  THIESSEN, Greg ,  KELLER BARRETT, Salka ,  BERRIOS, Christian ,  JACOBS, Aaron ,  LEHMANN, Taylor ,  PRINDLE, Marc ,  MERRILL, Lacey ,  VELLUCCI, Samantha

IPC分类号： C40B30/04

公开(公告)号：EP3912992A1

公开(公告)日：2021-11-24

申请号：EP20752298.8

申请日：2020-02-04

申请人： National University Corporation Ehime University

发明人： OCHI Toshiki ,  YASUKAWA Masaki ,  FUJIWARA Hiroshi ,  TAKENAKA Katsuto

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K16/00 ,  C07K16/46 ,  C07K19/00 ,  C40B40/08 ,  C40B40/10 ,  C12N5/0783 ,  C12N5/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/13 ,  C12N15/62 ,  C12Q1/02 ,  C12Q1/04 ,  C40B30/04 ,  C40B50/06 ,  G01N33/531 ,  C12P21/02 ,  C12P21/08

摘要： Provided are a CAR library used to screen scFvs that can be functional in CAR-T cells, and an scFv manufacturing method in which the CAR library is used. A chimeric antigen receptor (CAR) library of the present invention includes nucleic acids coding for first CARs. Each of the first CARs includes a first antigen-binding domain, a first transmembrane domain, and a first intracellular signaling domain. The first antigen-binding domain includes a first single-chain antibody (scFv) to be screened for the ability to bind to a target antigen. The first scFv includes a first heavy-chain variable region and a first light-chain variable region. The first heavy-chain variable region and the first light-chain variable region meet a predetermined condition.

公开(公告)号：EP3902919A1

公开(公告)日：2021-11-03

申请号：EP19902231.0

申请日：2019-12-24

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： BYRNE, Leah ,  STAUFFER, William R.

IPC分类号： C12N15/864 ,  C40B40/08 ,  C40B40/02 ,  C40B30/06 ,  C12Q1/70 ,  C12Q1/6897 ,  C07K14/015 ,  C07K14/005