公开(公告)号：EP2097517A2

公开(公告)日：2009-09-09

申请号：EP07872632.0

申请日：2007-10-16

申请人： Genelux Corporation

发明人： FRENTZEN, Alexa ,  CHEN, Nanhai ,  ZHANG, Qian ,  YU, Yong, A. ,  SZALAY, Aladar, A.

IPC分类号： C12N7/04 ,  C12N15/863 ,  C07K14/07 ,  A61K35/76 ,  A61K39/285 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/7068 ,  A61K33/24 ,  A61K35/76 ,  A61K38/1709 ,  A61K38/1793 ,  A61K38/20 ,  A61K38/204 ,  A61K38/36 ,  A61K38/484 ,  A61K39/12 ,  A61K39/285 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K48/0058 ,  A61K49/0008 ,  A61K49/0045 ,  A61K49/0047 ,  A61K49/0097 ,  A61K49/14 ,  A61K49/1896 ,  A61K2039/523 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/47 ,  C07K14/54 ,  C07K14/5412 ,  C07K14/7155 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/60 ,  C07K2319/61 ,  C07K2319/74 ,  C12N15/86 ,  C12N2710/14171 ,  C12N2710/24121 ,  C12N2710/24122 ,  C12N2710/24132 ,  C12N2710/24141 ,  C12N2710/24143 ,  C12N2710/24162 ,  C12Q1/04 ,  G01N33/574 ,  G01N33/585

摘要： Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.

公开(公告)号：EP0835133B1

公开(公告)日：2008-08-13

申请号：EP96922173.8

申请日：1996-06-03

申请人： Connaught Technology Corporation

发明人： PAOLETTI, Enzo ,  MAKI, Joanne

IPC分类号： A61K39/295 ,  A61K39/275 ,  A61K39/285

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/5254 ,  A61K2039/70 ,  C07K14/33 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/16222 ,  C12N2710/16622 ,  C12N2710/16722 ,  C12N2710/24022 ,  C12N2710/24043 ,  C12N2710/24122 ,  C12N2710/24143 ,  C12N2730/10122 ,  C12N2740/13022 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2750/14322 ,  C12N2760/12022 ,  C12N2760/16122 ,  C12N2760/18122 ,  C12N2760/18722 ,  C12N2760/20022 ,  C12N2760/20122 ,  C12N2770/24022 ,  C12N2770/24122 ,  Y10S530/826

公开(公告)号：EP0831899B1

公开(公告)日：2008-08-13

申请号：EP96922179.5

申请日：1996-06-03

申请人： Connaught Technology Corporation

发明人： PAOLETTI, Enzo ,  FISCHER, Laurent ,  LEGROS, François-Xavier

IPC分类号： A61K39/12 ,  A61K39/295 ,  A61K39/285 ,  A61K39/275 ,  C12N7/01 ,  C12N15/63 ,  C12N7/00 ,  C12N15/40 ,  C07K14/08 ,  C07K16/10

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/5254 ,  C07K14/33 ,  C07K16/10 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16222 ,  C12N2710/16622 ,  C12N2710/16722 ,  C12N2710/24022 ,  C12N2710/24043 ,  C12N2710/24062 ,  C12N2710/24122 ,  C12N2710/24143 ,  C12N2710/24162 ,  C12N2730/10122 ,  C12N2740/13022 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2750/14322 ,  C12N2760/12022 ,  C12N2760/16122 ,  C12N2760/18122 ,  C12N2760/18722 ,  C12N2760/20022 ,  C12N2770/16022 ,  C12N2770/24022 ,  C12N2770/24122

公开(公告)号：EP1925662A1

公开(公告)日：2008-05-28

申请号：EP07023799.5

申请日：1996-06-06

申请人： VIROGENETICS CORPORATION

发明人： Paoletti, Enzo ,  Pincus, Steven E. ,  Cox, William I. ,  Kauffman, Elizabeth B.

IPC分类号： C12N7/01 ,  A61K39/285 ,  A61K39/275 ,  A61K39/245 ,  C07K16/08 ,  C12P21/02

CPC分类号： C07K16/088 ,  A61K39/00 ,  C07K14/005 ,  C12N2710/16122 ,  C12N2710/24022 ,  C12N2710/24122 ,  C12N2760/20122

摘要： Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA of the recombinant viruses can be used as probes or for generating PCR primers.

摘要翻译： 公开并要求保护含有编码HCMV抗原的DNA的减毒重组病毒，以及使用病毒，来自其的表达产物和由病毒或表达产物产生的抗体的方法和组合物。 重组病毒可以是NYVAC或ALVAC重组病毒。 来自其的重组病毒和基因产物以及由病毒和基因产物产生的抗体具有几种预防，治疗和诊断用途。 重组病毒的DNA可用作探针或产生PCR引物。

公开(公告)号：EP1624890A2

公开(公告)日：2006-02-15

申请号：EP04705315.2

申请日：2004-01-26

申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER

发明人： TERAJIMA, Masanori ,  CRUZ, John ,  ENNIS, Francis, A.

IPC分类号： A61K39/285 ,  G01N33/569 ,  G01N33/50

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/5256 ,  A61K2039/57 ,  C12N2710/24122 ,  C12N2710/24134

摘要： The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8+ T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8+ T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.

公开(公告)号：EP1598425A1

公开(公告)日：2005-11-23

申请号：EP05017694.0

申请日：2001-11-22

申请人： Bavarian Nordic A/S

发明人： Chaplin, Paul ,  Howley, Paul ,  Meisinger-Henschel, Christine

IPC分类号： C12N15/863 ,  C12N15/39 ,  C12N7/04 ,  C12N5/10 ,  A61K39/285 ,  A61K48/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K48/00 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/24121 ,  C12N2710/24143 ,  C12N2740/16322

摘要： The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and which is characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus or its recombinants as medicament or vaccine. Additionally, a method for inducing an immune response even in immuno-compromised patients, patients with pre-existing immunity to the vaccine virus or patients undergoing antiviral therapies is provided.

摘要翻译： 本发明提供了一种减毒病毒，其衍生自改良的痘苗安卡拉病毒，其特征在于丧失其在人类细胞系中繁殖复制的能力。 它进一步描述从该病毒衍生的重组病毒和病毒或其重组体作为药物或疫苗的用途。 另外，提供了即使在免疫受损的患者中也引起免疫应答的方法，具有对疫苗病毒的预先存在的免疫的患者或进行抗病毒治疗的患者的方法。

公开(公告)号：EP1589994A2

公开(公告)日：2005-11-02

申请号：EP04702130.8

申请日：2004-01-14

申请人： THE WISTAR INSTITUTE

发明人： GERHARD, Walter ,  OTVOS, Laszlo

IPC分类号： A61K39/145 ,  A61K39/38 ,  A61K39/12 ,  A61K39/285 ,  C07K17/00 ,  C07K16/00

CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/55544 ,  A61K2039/55561 ,  A61K2039/6025 ,  A61K2039/6087 ,  A61K2039/645 ,  A61K2039/70 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/472

摘要： The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.

公开(公告)号：EP1312678B1

公开(公告)日：2005-09-07

申请号：EP03001378.3

申请日：1996-07-03

申请人： GSF Forschungszentrum für Umwelt und Gesundheit GMBH

发明人： Sutter, Gerd ,  Ohlmann, Marion ,  Erfle, Volker

IPC分类号： C12N15/863 ,  C12N15/49 ,  C12N5/10 ,  A61K39/285

CPC分类号： C12N15/86 ,  A61K48/0091 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N9/0059 ,  C12N9/1247 ,  C12N2710/24143 ,  C12N2740/16322 ,  Y02A50/412

摘要： Recombinant MVA viruses containing and capable of expressing foreign genes which is inserted at the site of a naturally occuring deletion within the MVA genome, and the use of such recombinant MVA viruses for the production of polypeptides, e.g. antigenes or therapeutic agents, and for the production of recombinant viruses for vaccines, or viral vectors for gene therapy.

公开(公告)号：EP1539974A1

公开(公告)日：2005-06-15

申请号：EP03794024.4

申请日：2003-09-05

申请人： THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

发明人： O'NEILL, Luke, Anthony, John ,  BOWIE, Andrew, Graham ,  HARTE, Mary, Theresa ,  SMITH, Geoffrey, Lilley ,  HAGA, Ismar, Rocha ,  MALONEY, Geraldine

IPC分类号： C12N15/86 ,  C07K14/07 ,  A61K39/285 ,  A61K38/16

CPC分类号： C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24122 ,  C12N2710/24143 ,  C12N2710/24162 ,  G01N33/5041

摘要： An orthopoxvirus vector, such as vaccinia, is described in which the A52R protein from vaccinia, or a closely related protein from any orthopoxvirus is not expressed or is expressed but is non-functional. Also described is the use of a vaccinia virus A52R protein or a closely related protein from any orthopoxvirus, or a functional peptide, peptidometic, fragment or derivative thereof, or a DNA vector expressing any of the above in the modulation and/or inhibition of IL1R/TLR superfamily signalling.

公开(公告)号：EP1312679A1

公开(公告)日：2003-05-21

申请号：EP03001379.1

申请日：1996-07-03

申请人： GSF Forschungszentrum für Umwelt und Gesundheit GMBH

发明人： Sutter, Gerd ,  Ohlmann, Marion ,  Erfle, Volker

IPC分类号： C12N15/863 ,  C12N15/53 ,  C12N15/54 ,  C12N5/10 ,  A61K39/285

CPC分类号： C12N15/86 ,  A61K48/0091 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N9/0059 ,  C12N9/1247 ,  C12N2710/24143 ,  C12N2740/16322 ,  Y02A50/412

摘要： Recombinant MVA viruses containing and capable of expressing foreign genes which is inserted at the site of a naturally occuring deletion within the MVA genome, and the use of such recombinant MVA viruses for the production of polypeptides, e.g. antigenes or therapeutic agents, and for the production of recombinant viruses for vaccines, or viral vectors for gene therapy.