公开(公告)号：EP1555259A1

公开(公告)日：2005-07-20

申请号：EP05000594.1

申请日：2005-01-13

申请人： Sumitomo Chemical Company, Limited

发明人： Ohshita, Jun

IPC分类号： C07D239/26 ,  C07D239/38 ,  C07D241/12 ,  C07D237/08 ,  C07D239/28 ,  C07D239/34 ,  C07D237/12 ,  C07D239/30 ,  C07D237/18 ,  C07D241/16 ,  C07D241/18 ,  C07D253/06 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/707

CPC分类号： C07D239/26 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  C07D237/08 ,  C07D237/12 ,  C07D237/18 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18 ,  C07D253/07

摘要： The present invention provides a malononitrile compound represented by the formula (I):

The malononitrile compound has an efficient pesticidal activity and can control effectively pests.

摘要翻译： 本发明提供了由式（I）表示的丙二腈化合物：丙二腈化合物具有有效的杀虫活性并且可以有效地控制害虫。

公开(公告)号：EP1523475A1

公开(公告)日：2005-04-20

申请号：EP03763692.5

申请日：2003-07-03

申请人： Aventis Pharma Deutschland GmbH

发明人： SCHOENAFINGER, Karl ,  DEFOSSA, Elisabeth ,  KADEREIT, Dieter ,  VON ROEDERN, Erich ,  KLABUNDE, Thomas ,  BURGER, Hans-Joerg ,  HERLING, Andreas ,  WENDT, Karl-Ulrich

IPC分类号： C07D211/62 ,  C07D249/08 ,  C07D257/04 ,  C07D271/10 ,  C07D253/06 ,  C07D231/26 ,  C07D307/68 ,  C07D235/18 ,  A61K31/17 ,  A61P3/10

CPC分类号： C07D211/60 ,  C07D211/62 ,  C07D231/12 ,  C07D231/26 ,  C07D233/56 ,  C07D235/18 ,  C07D249/08 ,  C07D249/12 ,  C07D253/07 ,  C07D257/04 ,  C07D271/10 ,  C07D271/113 ,  C07D307/68

摘要： The invention relates to heterocyclically substituted benzoylureas, in addition to their physiologically compatible salts and physiologically functional derivatives. The invention relates in particular to compounds of formula (I), in which the groups are defined as cited in the description, in addition to their physiologically compatible salts and to a method for producing said compounds. The compounds are suitable e.g. for treating type 2 diabetes.

公开(公告)号：EP1400518A4

公开(公告)日：2005-04-20

申请号：EP02722772

申请日：2002-04-25

申请人： NIPPON SHINYAKU CO LTD

发明人： ASAKI TETSUO ,  HAMAMOTO TAISUKE ,  KUWANO KEIICHI

IPC分类号： A61K31/4418 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/505 ,  A61K31/53 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P11/08 ,  A61P13/12 ,  A61P17/02 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D213/74 ,  C07D239/42 ,  C07D241/12 ,  C07D241/18 ,  C07D241/20 ,  C07D253/07 ,  C07D401/04 ,  C07D403/04 ,  C07D409/12 ,  C07D253/06 ,  C07D239/34 ,  C07D239/38

CPC分类号： C07D409/12 ,  A61K31/4418 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/505 ,  A61K31/53 ,  C07D213/74 ,  C07D239/42 ,  C07D241/12 ,  C07D241/18 ,  C07D241/20 ,  C07D253/07 ,  C07D401/04 ,  C07D403/04

摘要： The invention provides compounds useful as PGI2 receptor agonist and pharmaceutical compositions, particularly pharmaceutical compositions containing as the active ingredient compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein R1 and R2 are each independently optionally substituted aryl; Y is N, CH, or the like; Z is N, CH, or the like; A is NH, NR5, O, S, ethylene, or the like; R5 is alkyl or the like; D is alkylene or alkenylene; E is phenylene or a single bond; G is O, S, CH2, or the like; R3 and R4 are each independently hydrogen or alkyl; and Q is carboxyl, alkoxycarbonyl, tetrazolyl, carbamoyl, N-(alkylsulfonyl)carbamoyl, or the like.

摘要翻译： 本发明提供了可用作PGI 2受体激动剂的化合物和药物组合物。 本发明涉及包含由下式表示的化合物的药物组合物：＆lt; CHEM＆gt;（R 1和R 2相同或不同，各自表示任意取代的芳基，Y表示 N或CH，Z表示N或CH，A表示NH，NR 5，O，S或亚乙基，R 5表示烷基，D表示亚烷基或亚烯基，E表示亚苯基或单键，G表示O， S或CH 2，R 3和R 4相同或不同，各自表示氢或烷基，Q表示羧基，烷氧基羰基，四唑基，氨基甲酰基或N-（烷基磺酰基）氨基甲酰基）或其药学上可接受的盐 作为活性成分。

公开(公告)号：EP1458692A1

公开(公告)日：2004-09-22

申请号：EP02807048.0

申请日：2002-12-18

申请人： Apotex Pharmachem Inc.

发明人： GUNTOORI, Bhaskar, Reddy ,  CHE, Daqing ,  MURTHY, Keshava, K., S.

IPC分类号： C07D253/06 ,  C07C277/08 ,  C07C281/18

CPC分类号： C07D253/075

摘要： A process for the manufacture of 3,5-diamino-kgg6-substituted-1,2,4-triazines is disclosed which comprises the steps of: (a) reacting a compound of formula (II): with aminoguanidine salts, (b) dehydrating the compound obtained to form a compound of formula (IV), and (c) cyclization of the compound of formula (IV) into a 3,5-diamino-6-substituted-1,2,4-triazine compound of formula (I) or into a hydrated form thereof.

公开(公告)号：EP1311492B1

公开(公告)日：2004-09-08

申请号：EP02758308.7

申请日：2002-07-04

申请人： Helm AG ,  CF Pharma Gyogyszergyarto Kft.

发明人： SCHNEIDER, Géza ,  GEGÖ, Csaba, Lehel ,  ONDI, Levente ,  MATE, Attila, Gergely ,  LUKACS, Ferenc ,  NYERGES, Miklús ,  GARACZI, Sándor

IPC分类号： C07D253/06 ,  C07C281/18 ,  C07C257/14 ,  C07C255/61 ,  C07C251/30

CPC分类号： C07D253/075 ,  C07C255/61 ,  C07C257/14 ,  C07C281/18 ,  C07C291/02

摘要： The invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by ring closure reaction from α-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone.

公开(公告)号：EP1363912A1

公开(公告)日：2003-11-26

申请号：EP02704706.7

申请日：2002-02-11

申请人： Bayer Aktiengesellschaft

发明人： NIEWÖHNER, Ulrich ,  SCHAUSS, Dagmar ,  KÖNIG, Gerhard ,  HENDRIX, Martin ,  BÖSS, Frank-Gerhard ,  VAN DER STAAY, Franz-Josef ,  SCHREIBER, Rudy ,  SCHLEMMER, Karl-Heinz ,  MORIWAKI, Toshiya ,  NIEWÖHNER, Maria Theresia

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P25/00 ,  C07D253/06

CPC分类号： C07D253/07 ,  C07D487/04

摘要： The invention relates to novel substituted imidazotriazinones, to a method for their production and to the use thereof for producing medicaments, in particular to improve perception, powers of concentration, learning capacity and/or memory retentiveness.

摘要翻译： 本发明涉及新型取代的咪唑并三嗪酮，其制备方法及其用于制备药物的用途，特别是改善知觉，注意力，学习能力和/或记忆保持力的能力。

公开(公告)号：EP1311492A1

公开(公告)日：2003-05-21

申请号：EP02758308.7

申请日：2002-07-04

申请人： Helm AG ,  CF Pharma Gyogyszergyarto Kft.

发明人： SCHNEIDER, Géza ,  GEGÖ, Csaba, Lehel ,  ONDI, Levente ,  MATE, Attila, Gergely ,  LUKACS, Ferenc ,  NYERGES, Miklús ,  GARACZI, Sándor

IPC分类号： C07D253/06 ,  C07C281/18 ,  C07C257/14 ,  C07C255/61 ,  C07C251/30

CPC分类号： C07D253/075 ,  C07C255/61 ,  C07C257/14 ,  C07C281/18 ,  C07C291/02

摘要： The invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by ring closure reaction from α-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone.

公开(公告)号：EP0936216A4

公开(公告)日：2003-01-02

申请号：EP97939195

申请日：1997-09-05

申请人： NIPPON KAYAKU KK

发明人： SUZUKI YOSHIKAZU ,  ISHIDA KOICHI

IPC分类号： C07D213/64 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61P9/00 ,  A61P11/06 ,  C07D239/42 ,  C07D239/46 ,  C07D241/20 ,  C07D253/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D263/06 ,  C07D403/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D241/20 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  Y02P20/55

摘要： Novel acetamide derivatives having a substituted heterocycle and consecutive dicarbonyl structures represented by chemical formula (I), for example, 1-pyrimidinylacetamide compounds, 1-pyrazinylacetamide compounds and 1-triazinylacetamide compounds. Because of showing inhibitory activities on proteases of the chymotrypsin type, these compounds are useful as inhibitors for these enzymes, in particular, chymase inhibitors. In formula (I) R0 represents optionally substituted phenyl; R1 represents optionally substituted aryl, heteroaryl or aliphatic lower alkyl; R2 represents optionally substituted alkyl, arylalkyl or heteroarylalkyl; R3 represents hydrogen; acyl; sulfonyl; isocyanato; thiourea; hydrogen, optionally substituted lower alkyl; aryl(C¿1-7?)alkyl, heteroaryl(C1-7)alkyl, aryl or heteroaryl; X and Y independently represent each nitrogen or carbon; and Z represents polymethylene optionally substituted at the hydrogen atoms thereon.

公开(公告)号：EP1023287B1

公开(公告)日：2002-06-12

申请号：EP98949061.0

申请日：1998-10-14

申请人： PIERRE FABRE MEDICAMENT

发明人： PATOISEAU, Jean-François ,  DUPONT-PASSELAIGUE, Elisabeth ,  KOEK, Wouter

IPC分类号： C07D403/12 ,  A61K31/53 ,  C07D253/06 ,  C07D405/12 ,  C07D471/04

CPC分类号： C07D253/075 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

公开(公告)号：EP1178971A1

公开(公告)日：2002-02-13

申请号：EP00931917.9

申请日：2000-05-18

申请人： Pharmacia Corporation

发明人： SOUTH, Michael, S. ,  JONES, Darin, E. ,  RUEPPEL, Melvin, L.

IPC分类号： C07D239/54 ,  C07D253/06 ,  C07D417/12 ,  A61K31/505 ,  A61P7/02

CPC分类号： C07D239/545 ,  C07D253/075 ,  C07D417/12

摘要： The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.