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公开(公告)号：EP4328317A1
公开(公告)日：2024-02-28
申请号：EP22787940.0
申请日：2022-03-18
申请人： ENEOS Corporation
发明人： KUWAHARA Daichi
摘要： The object of the present invention is to provide a production method for β-cryptoxanthin with improved production efficiency. The present invention provides a method for producing β-cryptoxanthin by culturing bacteria of the genus Paracoccus at a given dissolved oxygen concentration, wherein the bacteria of the genus Paracoccus are bacteria forming yellow to orange colonies; or bacteria whose endogenous crtW gene has been partially or completely deleted or inactivated to lose the ability to produce a functional crtW enzyme.
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22.发明公开
公开(公告)号：EP4328302A1
公开(公告)日：2024-02-28
申请号：EP22192384.0
申请日：2022-08-26
摘要： The invention relates to a method for preparing functional membrane attached monooxygenases in cell-free systems which comprises at least the following steps:
a) providing a reaction medium comprising at least the following components:
a nucleic acid template coding for a Cytochrome P450 monooxygenase classified as EC 1.14.-.-, an RNApolymerase, a eukaryotic cell lysate containing ER-derived membrane vesicles which comprise NADPH-Cytochrom-P450-oxidoreductase (CPR), optionally heme or heme derivatives, in particular heme complexes selected from the group comprising or consisting of hematin and hemin;
b) performing a cell-free reaction to synthesize the monooxygenase protein, wherein the cell-free translation reaction is performed at a temperature in the range from 18 to 33°C.
The invention further relates to a reaction medium for preparing a functional Cytochrome P450 monooxygenase classified as EC 1.14.-.- in a cell-free system comprising at least the following components:
a nucleic acid template coding for a Cytochrome P450 classified as EC 1.14.-.-, an RNA polymerase, a eukaryotic cell lysate containing membrane vesicles which comprise NADPH-Cytochrom-P450-oxidoreductase (CPR), heme or heme derivatives, in particular heme complexes selected from the group comprising or consisting of hematin and hemin.-
公开(公告)号：EP4328215A1
公开(公告)日：2024-02-28
申请号：EP22899139.4
申请日：2022-11-29
申请人： LG Chem, Ltd.
发明人： HAN, Sang Won , KIM, Taeho , JEONG, Yongbok , AHN, Sangbum , JUNG, Woochul , KANG, Donggyun , KIM, Si Min , KIM, Jimyeong , BANG, Yongju , KIM, Jeong Eun , CHOE, Jae Hoon
摘要： The present invention relates to a process of recovering alkali metal salt hydrate and 3-hydroxypropionic acid, comprising: forming and separating 3-hydroxypropionic acid salt crystal from a concentrate containing 3-hydroxypropionic acid in the presence of an alkali metal salt; and adding an acid to the aqueous solution containing the separated 3-hydroxypropionic acid salt crystal to form and separate an alkali metal salt hydrate and 3-hydroxypropionic acid.
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公开(公告)号：EP4317437A1
公开(公告)日：2024-02-07
申请号：EP22779984.8
申请日：2022-03-11
发明人： ISAKA Koji , MIYATAKE Ryo , KATAYAMA Sayaka
IPC分类号： C12N15/53 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/31 , C12N15/63 , C12P7/02 , C12P7/24 , C12P13/00 , C12N15/10
摘要： There are provided a recombinant polypeptide having an excellent carboxylic acid reducing activity, and a production method of an aliphatic compound using the recombinant polypeptide.
A recombinant polypeptide has: (a) an amino acid sequence A having a sequence identity of 60% or higher, 65% or higher, 70% or higher, 75% or higher, 80% or higher, 85% or higher, 88% or higher, 90% or higher, 95% or higher, 97% or higher, 98% or higher, or 99% or higher with an amino acid sequence set forth in SEQ ID NO: 1; (b) a substitution of at least one amino acid at a position corresponding to a substrate-binding site of a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1 in the amino acid sequence A; and (c) a carboxylic acid reducing activity.-
公开(公告)号：EP4316507A1
公开(公告)日：2024-02-07
申请号：EP22776151.7
申请日：2022-03-25
发明人： RYU, Incheol , JEONG, Daeun , AN, Sihyeon , KIM, Seong Heon , KIM, Yunseon , RYOO, Kanghyun , LEE, Hyunseung , YOON, Dong-Oh , LEE, Myoungwoo , WON, Misun , IM, Joo-Young
IPC分类号： A61K38/44 , A61K38/16 , A61K38/19 , A61P35/00 , A23L33/17 , A23L33/195 , C12N15/63 , C12N9/02 , C07K14/55 , C07K14/54
摘要： The present invention relates to a composition for preventing or treating cancer, comprising a dual expression vector, and more specifically, to a method for effectively treating cancer by simultaneously inducing the actions of cancer metabolism drugs and cancer immunotherapy drugs by using a dual expression vector for simultaneously expressing an HIF-1α inhibitor and anticancer cytokines.
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公开(公告)号：EP4314271A1
公开(公告)日：2024-02-07
申请号：EP22782341.6
申请日：2022-04-01
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公开(公告)号：EP3744835B1
公开(公告)日：2024-01-31
申请号：EP20183740.8
申请日：2013-05-29
发明人： JOUNG, Keith, J , MAEDER, Morgan , ANGSTMAN, James
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公开(公告)号：EP4234704A3
公开(公告)日：2024-01-03
申请号：EP23169866.3
申请日：2013-10-22
申请人： SEKISUI CHEMICAL CO., LTD. , Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
摘要： To provide a series of techniques capable of producing isoprene from syngas or the like.
Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell.-
29.发明授权
公开(公告)号：EP3846773B1
公开(公告)日：2023-12-20
申请号：EP19758982.3
申请日：2019-08-28
IPC分类号： A61K8/66 , A61Q19/08 , A61K8/9789 , A23L3/3571 , A23B4/22 , C12N9/02 , C12N15/82
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公开(公告)号：EP3936188B1
公开(公告)日：2023-11-29
申请号：EP21186914.4
申请日：2016-04-20
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