公开(公告)号：EP2807185A2

公开(公告)日：2014-12-03

申请号：EP13701288.6

申请日：2013-01-28

申请人： Laboratorios del. Dr. Esteve, S.A. ,  Fundació Privada Institut de Recerca de la SIDA-Caixa ,  Institució Catalana de Recerca i Estudis Avançats

发明人： BRANDER, Christian ,  MOTHE PUJADAS, Beatriz ,  LLANO, Anuska

IPC分类号： C07K14/16 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/575 ,  C07K2319/35 ,  C12N7/00 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.

公开(公告)号：EP2732051A2

公开(公告)日：2014-05-21

申请号：EP12737766.1

申请日：2012-07-12

申请人： Laboratorios del. Dr. Esteve, S.A. ,  Fundació Privada Institut de Recerca de la SIDA-Caixa

发明人： ARNEDO VALERO, Mireia ,  PLANA PRADES, Montserrat ,  GATELL ARTIGAS, Josep María

IPC分类号： C12Q1/68

CPC分类号： C12N15/1132 ,  A61K31/713 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/702 ,  C12Q1/703 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The invention relates to methods for the identification of HIV-1infected subjects capable of controlling viral load based on the determination of the expression levels of several miRNAs. In addition, the invention also relates to methods for controlling HIV infection by using some of the differentially expressed miRNAs or polynucleotides encoding said miRNAs,as well as to compositions comprising a miRNA or a polynucleotide encoding said miRNA and an anti-HIV agent.

公开(公告)号：EP2687852A1

公开(公告)日：2014-01-22

申请号：EP12382283.5

申请日：2012-07-17

申请人： Laboratorios del. Dr. Esteve, S.A. ,  Fundació Privada Institut de Recerca de la SIDA-Caixa

发明人： Cabrera Navarro, Cecilia ,  Curriu Marti, Marta ,  Massanella Luna, Marta ,  Carrillo Molina, Jorge ,  Blanco Arbues, Julian Miguel

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/70596 ,  G01N2800/306 ,  G01N2800/50

摘要： The present invention relates to a method for diagnosing CFS or a predisposition thereto in vitro which comprises determining the levels of CD25, CD69, NKp46 and CD57 biomarkers in CD56+CD16+ NK cells and comparing with a reference value wherein increased levels of said markers is indicative the subject suffers or is predisposed to suffering CFS. Likewise the invention relates to a kit comprising reagents for assaying the levels of CD25, CD69, NKp46 and CD57 in CD56+CD16+ NK cells and to the use of said kit for the diagnosis of CFS or of a predisposition thereto. In addition, the invention relates to a reagent for inhibiting the expression or activity of at least one biomarker selected from the group consisting of CD69, NKp46 and CD5 or to a reagent for inducing the expression or activity of at least one biomarker selected from CD25, CD57, CD56 and Ki67 for use in the treatment or prevention of CFS in a subject in need thereof. Finally the invention relates to a kit comprising a reagent for inhibiting or inducing a biomarker of the invention and to the use of said kit for the treatment or prevention of CFS.

摘要翻译： 本发明涉及用于诊断体外CFS或其易感性的方法，其包括测定CD56 + CD16 + NK细胞中CD25，CD69，NKp46和CD57生物标志物的水平，并与参考值进行比较，其中所述标记物的增加水平是指示性的 受试者遭受或倾向于患有CFS。 同样，本发明涉及包含用于测定CD56 + CD16 + NK细胞中CD25，CD69，NKp46和CD57水平的试剂的试剂盒，以及所述试剂盒用于诊断CFS或其易感性的用途。 此外，本发明涉及用于抑制至少一种选自CD69，NKp46和CD5的生物标志物的表达或活性的试剂，或涉及用于诱导至少一种选自CD25， CD57，CD56和Ki67，用于治疗或预防有需要的受试者中的CFS。 最后，本发明涉及包含用于抑制或诱导本发明的生物标志物的试剂以及所述试剂盒用于治疗或预防CFS的试剂盒。

公开(公告)号：EP2447277A1

公开(公告)日：2012-05-02

申请号：EP10382284.7

申请日：2010-10-28

申请人： Laboratorios del. Dr. Esteve, S.A. ,  Fundació Privada Institut de Recerca de la SIDA-Caixa

发明人： Blanco Arbúes, Julián Miguel ,  Carrillo Molina, Jorge ,  Curriu Martí, Marta

IPC分类号： C07K14/16 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The invention relates to relates to human immunodeficiency virus (HIV) immunogens based on gp41 epitopes located in the membrane proximal extracellular region (MPER). The immunogens of the present invention are capable of inducing the expression of neutralizing antibodies. Various forms of these isolated immunogens are disclosed and exemplified. Isolated nucleic acid molecules expressing relevant portions of these immunogens, as well as the vectors and host cells utilized for their production, are also within the scope of the present invention.

摘要翻译： 本发明涉及基于位于膜近端细胞外区域（MPER）的gp41表位的人免疫缺陷病毒（HIV）免疫原。 本发明的免疫原能够诱导中和抗体的表达。 公开和示例了这些分离的免疫原的各种形式。 表达这些免疫原相关部分的分离的核酸分子以及用于其生产的载体和宿主细胞也在本发明的范围内。