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31.发明授权SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION 失效取代AZAINDOLYLIDENDERIVATE及其制备方法
公开(公告)号：EP0715628B1
公开(公告)日：2002-10-02
申请号：EP95921777.9
申请日：1995-05-30
IPC分类号： C07D471/04 , C07F9/6561 , A61K31/435
CPC分类号： C07D471/04 , C07F9/6561
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公开(公告)号：EP1227795A2
公开(公告)日：2002-08-07
申请号：EP00979540.2
申请日：2000-10-30
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/575 , A61K31/704 , A61K45/06 , A61K47/24 , A61K2300/00
摘要： An antitumor pharmaceutical composition comprising a liophilizate of a water insoluble alkycycline, a phospholipid, a buffer and a pharmaceutically acceptable lyophilization excipient. The composition is highly stable and exerts a strong antitumor activity without substantially inducing side effects.
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33.发明公开SYNERGISTIC COMPOSITION COMPRISING DAUNORUBICIN DERIVATIVES AND ANTIMETABOLITE COMPOUNDS 有权协同增效组合，柔红霉素衍生物和抗代谢药物含
公开(公告)号：EP1200099A1
公开(公告)日：2002-05-02
申请号：EP00949297.6
申请日：2000-07-10
IPC分类号： A61K31/70 , A61P35/00 , A61K31/505
CPC分类号： A61K31/70 , A61K31/495 , A61K2300/00
摘要： The combined use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4'-methansulfonyl daunorubicin and an antimetabolite compound in the treatment of tumors, especially in the treatment or prevention of metastasis or in the treatment of tumors by the inhibition of angiogenesis.
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34.发明公开COMBINED PREPARATIONS COMPRISING DAUNORUBICIN DERIVATIVES AND ANTI HER2 ANTIBODIES 审中-公开组合型组合物柔红霉素衍生物和抗HER2抗体entahlten
公开(公告)号：EP1200098A2
公开(公告)日：2002-05-02
申请号：EP00945903.3
申请日：2000-07-10
IPC分类号： A61K31/70 , A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K39/395 , A61K2039/505 , A61K31/70 , A61K2300/00
摘要： There are provided the combined use of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methansulfonyl daunorubicin or 4-demethoxy-N,N-bis(2-chloroethyl)-4'-methansulfonyl daunorubicin and a recombinant humanized anti-HER2 antibody, preferably trastuzumab, in the treatment of tumors and the use of said combination in the treatment and/or prevention of tumor metastasis.
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35.发明公开
公开(公告)号：EP1660475A1
公开(公告)日：2006-05-31
申请号：EP04763883.8
申请日：2004-08-06
发明人： VANOTTI, Ermes , D'ALESSIO, Roberto , TIBOLLA, Marcellino , VARASI, Mario , MONTAGNOLI, Alessia , SANTOCANALE, Corrado , ORSINI, Paolo , PILLAN, Antonio
IPC分类号： C07D401/04 , C07D519/00 , A61K31/506 , A61K31/52 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/00 , A61P13/08 , A61P17/06 , A61P9/10 , A61P11/00 , A61P19/02 , A61P13/12 , A61K45/06
CPC分类号： C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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36.发明公开PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开PYRAZOLYLINDOLDERIVATE，作为激酶抑制剂的工作方法及其和药物组合物含
公开(公告)号：EP1648884A2
公开(公告)日：2006-04-26
申请号：EP04763124.7
申请日：2004-07-08
IPC分类号： C07D403/04 , A61K31/4155
CPC分类号： C07D403/04 , A61K31/416 , C07D401/14 , C07D403/14 , C07D405/14
摘要： Pyrazolyl-indole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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37.发明公开NEMORUBICIN AS RADIOSENSITIZER IN COMBINATION WITH RADIATION THERAPY AGAINST TUMORS 审中-公开放射治疗对癌症奈莫ALS放射增敏剂
公开(公告)号：EP1603575A2
公开(公告)日：2005-12-14
申请号：EP04716607.9
申请日：2004-03-03
IPC分类号： A61K31/704 , A61P35/00 , A61K31/282
CPC分类号： A61K45/06 , A61K31/282 , A61K31/704 , A61K33/24 , A61K41/00 , A61K2300/00
摘要： The present invention relates to a morpholinyl anthracycline derivative for use as radiosensitizer, to be administered in combination with radiation therapy, so that a synergistic effect can be revealed.
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公开(公告)号：EP1282602B1
公开(公告)日：2005-09-21
申请号：EP01936253.2
申请日：2001-04-19
IPC分类号： C07D213/55 , C07D233/88 , C07D233/50 , C07D239/12 , A61K31/4402 , A61K31/4168
CPC分类号： C07D401/12 , C07D213/55 , C07D233/50 , C07D233/88 , C07D239/12
摘要： Novel propanoic acid derivatives are integrin receptor antagonists or inhibitors, in particular of the avb3 integrin receptor. The compounds of the invention are for instance useful for the treatment of solid tumors by inhibition of angiogenic growth of tumor vessel network, thus promoting tumor regression, inhibition of metastatic spread, thus avoiding cancer metastases, inhibition of bone resorption, thus controlling osteoporosis, inhibition of smooth muscle cells migration into neointima, thus blocking restenosis after percutaneous coronary angioplasty and the treatment of other pathological conditions mediated by cell adhesion, cell migration or angiogenesis such e.g. diabetic retinopaty, rheumatoid arthritis and inflammation.
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公开(公告)号：EP1377589B1
公开(公告)日：2005-09-07
申请号：EP02714136.5
申请日：2002-01-28
发明人： BERTA, Daniela , FELDER, Eduard , VULPETTI, Anna , VILLA, Marzia
IPC分类号： C07D498/04 , C07D413/04 , A61K31/415 , A61K31/435 , A61P35/00
CPC分类号： C07D413/04 , A61K31/4155 , A61K31/437 , C07D413/14
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公开(公告)号：EP1525183A1
公开(公告)日：2005-04-27
申请号：EP03762206.5
申请日：2003-06-30
发明人： BATTISTINI, Carlo , CASUSCELLI, Francesco , KELLY, Robert, C. , MAGGIORA, Linda, L. , MITCHELL, Mark, A. , PIUTTI, Claudia , REDING, Matthew, T.
IPC分类号： C07C229/58 , C07C323/63 , C07D257/04 , A61P31/12
CPC分类号： C07D207/335 , C07C229/58 , C07C233/51 , C07C233/62 , C07C233/80 , C07C233/87 , C07C255/58 , C07C275/24 , C07C279/14 , C07C309/59 , C07C317/36 , C07C317/48 , C07C323/63 , C07C2601/02 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D209/16 , C07D211/58 , C07D213/38 , C07D239/54 , C07D257/04 , C07D295/155 , C07D295/215 , C07D307/52 , C07D333/20 , C07D333/24
摘要： The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases.
摘要翻译： 本发明提供了用于治疗病毒感染和相关疾病，特别是HCV感染和相关疾病的式I化合物，组合物和方法。
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