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公开(公告)号：EP3612523A1
公开(公告)日：2020-02-26
申请号：EP18719794.2
申请日：2018-04-16
发明人： FRATTINI, Sara , LINGARD, Iain , HAMPRECHT, Dieter, Wolfgang , BAKKER, Remko, Alexander , ECKHARDT, Matthias , GOLLNER, Andreas , HEHN, Joerg, P. , LANGKOPF, Elke , WAGNER, Holger , WELLENZOHN, Bernd , WIEDENMAYER, Dieter
IPC分类号： C07D401/14 , A61P3/10 , A61K31/444 , A61K31/506
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32.发明公开
公开(公告)号：EP3532458A1
公开(公告)日：2019-09-04
申请号：EP17784652.4
申请日：2017-10-18
IPC分类号： C07D213/74 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/435 , A61P3/10
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33.发明授权
公开(公告)号：EP3331860B1
公开(公告)日：2019-07-17
申请号：EP16750134.5
申请日：2016-08-01
IPC分类号： C07D213/74 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/4418 , A61K31/4439 , A61K31/443 , A61K31/4433 , A61K31/4427 , A61K31/444 , A61K31/4965 , A61K31/513 , A61K31/4436 , A61K31/506 , A61P3/00 , A61P3/04 , A61P3/10
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34.发明公开
公开(公告)号：EP3331860A1
公开(公告)日：2018-06-13
申请号：EP16750134.5
申请日：2016-08-01
IPC分类号： C07D213/74 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/4418 , A61K31/4439 , A61K31/443 , A61K31/4433 , A61K31/4427 , A61K31/444 , A61K31/4965 , A61K31/513 , A61K31/4436 , A61K31/506 , A61P3/00 , A61P3/04 , A61P3/10
CPC分类号： C07D413/12 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/513 , A61K45/06 , C07D213/74 , C07D401/12 , C07D405/12 , C07D409/12
摘要： wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.
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公开(公告)号：EP3022210B1
公开(公告)日：2018-02-21
申请号：EP14738531.4
申请日：2014-07-14
IPC分类号： C07D519/00 , A61K31/437 , A61P3/00
CPC分类号： A61K31/437 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/541 , A61K45/06 , C07D493/04 , C07D519/00
摘要： The present invention relates to compounds of general formula I, wherein the group R1, R2, X and Y are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
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36.发明公开PROCESS AND INTERMEDIATES FOR PREPARING INDANYLOXYDIHYDROBENZOFURANYL ACETIC ACID DERIVATIVES AS GPR40 AGONISTS 有权工艺和中间体化合物醋酸衍生物作为INDANYLOXYDIHYDROBENZOFURANYL GPR40受体激动剂的制备
公开(公告)号：EP3049396A1
公开(公告)日：2016-08-03
申请号：EP14771872.0
申请日：2014-09-22
发明人： DAHMANN, Georg , WAGNER, Holger , ECKHARDT, Matthias , FRANK, Markus , SANTAGOSTINO, Marco , SCHNAUBELT, Juergen , STERTZ, Uwe , PACHUR, Thorsten
IPC分类号： C07D307/80
CPC分类号： C07D307/80 , C07D405/12 , C07D407/12 , C07D513/04
摘要： The present invention relates to compounds of formula (I) werein R
s denotes F or CF
3 , R
a denotes H or C
1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing said GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.摘要翻译： 本发明涉及到我worin RS表示F或CF 3的式化合物中，R表示H或C 1-4烷基且Z表示离去基团或在OPTIONALLY substituiertem或保护的羟基，适合作为中间体的indanyloxydihydrobenzofuranylacetic酸的合成方法， 其GPR40激动剂，一种用于制备合成中间体和用于制备所述GPR40激动剂利用在过渡金属催化剂的存在下与手性助剂的不对称催化氢化反应的进程。
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37.发明授权NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS 有权新型吲哚氧基二氢浮烯基乙酰乙酸衍生物及其作为GPR40受体激动剂的应用
公开(公告)号：EP2831053B1
公开(公告)日：2016-06-22
申请号：EP13724175.8
申请日：2013-03-25
发明人： ECKHARDT, Matthias , FRATTINI, Sara , HAMPRECHT, Dieter , HIMMELSBACH, Frank , LANGKOPF, Elke , LINGARD, Iain , PETERS, Stefan , WAGNER, Holger
IPC分类号： C07D307/80 , A61K31/343 , A61P3/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
CPC分类号： C07D405/12 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/553 , A61K45/06 , C07D307/80 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
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38.发明授权NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS 有权新INDANYLOXYDIHYDROBENZOFURANYLESSIGSÄURE衍生物及其作为GPR40受体激动剂
公开(公告)号：EP2831064B1
公开(公告)日：2016-02-17
申请号：EP13712760.1
申请日：2013-03-25
发明人： ECKHARDT, Matthias , FRATTINI, Sara , HAMPRECHT, Dieter , HIMMELSBACH, Frank , LANGKOPF, Elke , LINGARD, Iain , PETERS, Stefan , WAGNER, Holger
IPC分类号： C07D405/14 , C07D413/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D307/80 , A61K31/343 , A61P3/10
CPC分类号： C07D405/12 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/553 , A61K45/06 , C07D307/80 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
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39.发明公开NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS 有权新型吲哚氧基二氢浮烯基乙酰乙酸衍生物及其作为GPR40受体激动剂的应用
公开(公告)号：EP2831064A1
公开(公告)日：2015-02-04
申请号：EP13712760.1
申请日：2013-03-25
发明人： ECKHARDT, Matthias , FRATTINI, Sara , HAMPRECHT, Dieter , HIMMELSBACH, Frank , LANGKOPF, Elke , LINGARD, Iain , PETERS, Stefan , WAGNER, Holger
IPC分类号： C07D405/14 , C07D413/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D307/80 , A61K31/343 , A61P3/10
CPC分类号： C07D405/12 , A61K31/343 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/4025 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/553 , A61K45/06 , C07D307/80 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to compounds of general formula I, (I), wherein the groups R
1 , R
2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.摘要翻译： 本发明涉及通式（I）的化合物，其中基团R 1，R 2和m如权利要求1中所定义，其具有有价值的药理学性质，特别是与GPR40受体结合并调节其活性。 该化合物适用于治疗和预防可受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
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40.发明授权TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION 有权三环吡啶衍生物，用这类化合物，它们的用途及其制造方法DRUGS
公开(公告)号：EP2536733B1
公开(公告)日：2014-11-26
申请号：EP11704227.5
申请日：2011-02-17
发明人： WAGNER, Holger , BERTA, Daniela , FUCHS, Klaus , GIOVANNINI, Riccardo , HAMPRECHT, Dieter, Wolfgang , KONETZKI, Ingo , STREICHER, Ruediger , TRIESELMANN, Thomas
IPC分类号： C07D491/04 , C07D215/56 , A61K31/4741 , A61P9/00 , A61P3/06
CPC分类号： C07D491/04 , A61K31/506 , C07D215/56 , C07D491/20
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