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公开(公告)号：EP1856070B1
公开(公告)日：2011-07-27
申请号：EP06708325.3
申请日：2006-02-16
IPC分类号： C07D265/18 , A61K31/536
CPC分类号： C07D265/18
摘要： The invention concerns the use of compounds of formula (I), wherein the radicals R1, R2 and R3 are such as defined in the description and the claims, for producing a drug for treating respiratory diseases as well as novel compounds of formula (I). The invention also concerns a method for producing said compounds, and pharmaceutical formulations containing them.
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32.发明公开AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开AUSGEWÄHLTECGRP-ANTAGONISTEN，VERFAHREN ZU德仁HERSTELLUNG SOWIE德仁VERWENDUNG ALS医药有限公司
公开(公告)号：EP1940824A1
公开(公告)日：2008-07-09
申请号：EP06807391.5
申请日：2006-10-19
发明人： MUELLER, Stephan Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , SCHAENZLE, Gerhard , STENKAMP, Dirk , DOODS, Henri , ARNDT, Kirsten
IPC分类号： C07D401/14 , A61K31/435 , A61P25/06
CPC分类号： C07D401/14 , A61K31/551 , C07D413/14
摘要： The invention relates to the CGRP antagonists of general formula (I), where R1, R2, R3 and R4 are as defined in claim 1, the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof and the hydrates of the salts, in particularly the physiologically-acceptable salts with inorganic or organic acids or bases and any compound of general formula (I), in which one or more hydrogen atoms are exchanged for deuterium, medicaments comprising said compounds the use and methods for production thereof.
摘要翻译： 本发明涉及通式（I）的CGRP拮抗剂，其中R 1，R 2，R 3和R 4如权利要求1中所定义，其互变异构体，异构体，非对映异构体，对映异构体，水合物，混合物和盐以及盐的水合物 特别是与无机或有机酸或碱的生理上可接受的盐以及其中一个或多个氢原子被交换成氘的通式（I）的任何化合物，包含所述化合物的药物及其制备方法。
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33.发明公开HYDROXY-SUBSTITUIERTE BENZKONDENSIERTE HETEROZYKLEN ALS BETAAGONISTEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN 审中-公开羟基取代BENZKONDENSIERTE杂环做β兴奋剂，呼吸系统疾病的治疗
公开(公告)号：EP1789394A1
公开(公告)日：2007-05-30
申请号：EP05740683.7
申请日：2005-05-10
发明人： KONETZKI, Ingo , BOUYSSOU, Thierry , LUSTENBERGER, Philipp , SANTAGOSTINO, Marco , SCHNAPP, Andreas , HOENKE, Christoph
IPC分类号： C07D215/26 , C07D215/22 , C07D263/58 , C07D265/36 , A61K31/4704 , A61P11/00
CPC分类号： C07D215/26 , C07D215/22 , C07D263/58 , C07D265/36
摘要： The invention relates to the compounds of general formula (1), wherein the groups n, A, B, R1, R2 and R3 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to the use of these compounds as drugs, especially as drugs for use in the treatment of respiratory diseases.
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公开(公告)号：EP1765355A1
公开(公告)日：2007-03-28
申请号：EP05740045.9
申请日：2005-04-18
发明人： BOUYSSOU, Thierry , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , HOENKE, Christoph , LUSTENBERGER, Philipp , RUDOLF, Klaus , SCHROMM, Kurt , BUETTNER, Frank , HEINE, Claudia , SCHOLLENBERGER, Hermann
IPC分类号： A61K31/538 , A61P11/06
CPC分类号： A61K31/538
摘要： The invention relates to the use of compounds of general formula (1), wherein the radicals R1, R2 and R3 can have the meaning cited in the claims and in the description. The invention also relates to the production of a medicament for treating respiratory tract diseases.
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35.发明公开AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开SELECTED CGRP拮抗剂，它们的生产方法及其作为药物
公开(公告)号：EP1722792A1
公开(公告)日：2006-11-22
申请号：EP05715592.1
申请日：2005-02-26
发明人： LUSTENBERGER, Philipp , RUDOLF, Klaus , MUELLER, Stephan, Georg , STENKAMP, Dirk , DOODS, Henri , ARNDT, Kirsten , SCHAENZLE, Gerhard
IPC分类号： A61K31/435 , A61K31/445 , A61K31/4545 , A61K31/54 , A61K31/55 , A61P5/00 , C07D401/14
CPC分类号： C07D401/14
摘要： The invention relates to substituted piperidines of general formula (I), wherein A, B, D, E, X, R1 and R2 have the meaning cited in claim 1, and to the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof, in addition to the hydrate of the salts, in particular the physiologically compatible salts thereof having inorganic or organic acids. The invention also relates to medicaments containing said compounds, to the use thereof and method for the production thereof.
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36.发明公开3-(4-PIPERIDIN-1YLMETHYL-PHENYL)-PROPIONSÄURE-PHENYLAMID-DERIVATE UND VERWANDTE VERBINDUNGEN ALS MCH (MELANINE CONCENTRATING HORMONE) ANTAGONSITEN ZUR BEHANDLUNG VON ESSSTÖRUNGEN 审中-公开3-（4-哌啶-1-基甲基 - 苯基） - 丙酸苯酰胺衍生物和相关化合物作为MCH（黑色素浓缩激素）ANTAGONSITEN用于治疗进食障碍
公开(公告)号：EP1708698A1
公开(公告)日：2006-10-11
申请号：EP04803987.9
申请日：2004-12-17
发明人： LEHMANN-LINTZ, Thorsten , LUSTENBERGER, Philipp , ROTH, Gerald, Jürgen , SCHINDLER, Marcus , THOMAS, Leo , MUELLER, Stephan, Georg , STENKAMP, Dirk , LOTZ, Ralf, R., H. , RUDOLF, Klaus
IPC分类号： A61K31/40 , A61K31/4453 , C07D295/14 , C07D211/40 , C07D211/22 , C07D211/58 , C07D211/62 , C07C233/11 , A61P3/04
CPC分类号： C07D207/08 , C07C233/29 , C07C235/38 , C07C237/20 , C07C311/08 , C07D205/04 , C07D207/12 , C07D207/14 , C07D207/20 , C07D209/08 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/56 , C07D215/38 , C07D217/04 , C07D221/20 , C07D249/08 , C07D263/56 , C07D295/088 , C07D295/13 , C07D295/135 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D401/12 , C07D403/06 , C07D487/04 , C07D487/08
摘要： The invention relates to amid compounds of general formula (I), wherein groups and residuals A, B, b, W, X, Y, Z, R1, R2 and R3 have significances given in a claim 1. In addition, said invention relates to drugs containing at least one type of inventive amid. Because of the antagonist activity of an MCH-receptor, the inventive drugs are suitable for treating metabolic disturbances and/or eating disorders, in particular adiposity, bulimia, anorexia, hyperphagia and diabetes.
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公开(公告)号：EP1765355B1
公开(公告)日：2013-03-06
申请号：EP05740045.9
申请日：2005-04-18
发明人： BOUYSSOU, Thierry , KONETZKI, Ingo , PESTEL, Sabine , SCHNAPP, Andreas , HOENKE, Christoph , LUSTENBERGER, Philipp , RUDOLF, Klaus , SCHROMM, Kurt , BUETTNER, Frank , HEINE, Claudia , SCHOLLENBERGER, Hermann
IPC分类号： A61K31/538 , A61P11/06
CPC分类号： A61K31/538
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38.发明授权
公开(公告)号：EP1761509B1
公开(公告)日：2011-05-04
申请号：EP05747842.2
申请日：2005-05-10
发明人： BOUYSSOU, Thierry , KONETZKI, Ingo , SCHNAPP, Andreas , HOENKE, Christoph , LUSTENBERGER, Philipp , RUDOLF, Klaus , SANTAGOSTINO, Marco
IPC分类号： C07D265/28 , A61K31/538 , C07C215/30 , A61P11/00
CPC分类号： C07D265/28
摘要： The invention relates to the compounds of formula (1), wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X are defined as in the claims and in the description. The invention also relates to the use of these compounds as drugs, especially as drugs for use in the treatment of inflammatory and obstructive respiratory diseases.
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39.发明授权AUSGEWÄHLTE CGRP-ANTAGONISTEN, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DEREN VERWENDUNG ALS ARZNEIMITTEL 有权SELECTED CGRP拮抗剂，它们的生产方法及其作为药物
公开(公告)号：EP1737842B1
公开(公告)日：2010-08-18
申请号：EP05731650.7
申请日：2005-04-09
发明人： MUELLER, Stephan Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/14 , C07D471/10 , C07D513/04 , C07D453/04 , C07D401/04 , C07D451/04 , C07D471/04 , C07D495/04 , C07D487/08 , A61K31/4545 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04 , C07D451/04 , C07D453/02 , C07D487/04 , C07D487/08
摘要： The invention relates to the CGRP antagonists of general formula (I), wherein A, X and R1 to R3 are defined as in claim 1. The invention also relates to the tautomers, diastereomers, enantiomers, hydrates, mixtures and salts thereof and to the hydrates of said salts, especially their physiologically acceptable salts with inorganic or organic acids, to drugs comprising said compounds, to their use and to a method for producing the same.
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40.发明授权2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZDIAZEPIN-3-YL-PIPERIDINE ALS CGRP-ANTAGONISTEN 有权2-OXO-1,2,4,5-四氢-1,3-苯并噻唑-3-基-L-哌啶盐酸盐CGRP-ANTAGONISTEN
公开(公告)号：EP1863791B1
公开(公告)日：2008-11-12
申请号：EP06723571.3
申请日：2006-03-21
发明人： MUELLER, Stephan, Georg , RUDOLF, Klaus , LUSTENBERGER, Philipp , STENKAMP, Dirk , SANTAGOSTINO, Marco , PALEARI, Fabio , DREYER, Alexander , ARNDT, Kirsten , DOODS, Henri , SCHAENZLE, Gerhard
IPC分类号： C07D401/04 , C07D401/14 , A61K31/551 , A61P25/06
CPC分类号： C07D401/14 , C07D401/04
摘要： The invention relates to novel CGRP antagonists of general formula (I), in which B, R1 and R2 are defined as cited in claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts, in addition to the hydrates of their salts, in particular their physiologically compatible salts, with inorganic or organic acids or bases. The invention also relates to medicaments containing said compounds, to their use and to a method for their production.
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