摘要:
The invention relates to bicyclic heterocycles of general formula (I), in which Ra, Rb, Rc, Rd, Re and X are as defined in claim 1, the tautomers, stereoisomers, mixtures and salts thereof, in particular, the physiologically-acceptable salts thereof with inorganic and organic acids with useful pharmacological properties, in particular, an inhibitory effect on signal transduction brought about by tyrosine kinases, the use thereof for the treatment of diseases, in particular of tumour diseases and benign prostatic hyperplasia (BPH), diseases of the lungs and airways and production thereof.
摘要:
The invention relates to D-glucopyranosyl phenyl-substituted cyclene of general formula (I), in which: radicals R1 to R6, Z, Cy as well as R7a, R7b, R7c, R7d are defined as in Claim 1. The inventive compounds have an inhibitory effect upon the sodium-dependent glucose co-transporter SGLT. The invention also relates to medicaments for treating metabolic diseases.
摘要:
The invention relates to substituted imidazopyridazine diones of general formula (I) wherein R1 to R4 have the designation defined in patent claim 1. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts of said diones, comprising valuable pharmacological properties, especially an inhibitive effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要:
The invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula (I), where R1 to R4 and X are as defined in claims 1 to 6, the tautomers, enantiomers, diastereomers, mixtures and salts thereof with useful pharmacological properties, in particular an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要:
The invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula (I) wherein R1 - R4 are defined as in Claim, the tautomers thereof, the stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, especially an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要:
The invention relates to substituted xanthines of general formula (I) wherein R1 to R3 have the designations cited in patent claims 1 to 16, and to the tautomers, stereoisomers, mixtures, prodrugs and salts thereof, which have precious pharmacological properties, especially an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要:
The invention relates to a crystalline hydrate of 1-chloro-4-(ß-D-glucopyranos-1-yl)-2-(4- ethynyl-benzyl)-benzene and to crystalline complexes between 1-chloro-4-(ß-D- 5 glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and a natural amino acid, to methods for the preparation thereof, as well as to uses thereof for preparing medicaments.
摘要:
The invention relates to xanthines presented by a general formula (I), wherein R1 to R4 are equal to these defined in the claim n° 1, and to tautomers, stereoisomers, mixtures, pro-drugs and the salts thereof. Said compounds exhibit advantages pharmacological properties, in particular an inhibiting action on the activity of enzyme dipeptidylpeptidasa-IV (DPP-IV).