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公开(公告)号：EP1019045B1
公开(公告)日：2005-06-08
申请号：EP98932921.4
申请日：1998-06-26
发明人： BEIGHT, Douglas, Wade , CRAFT, Trelia, Joyce , FRANCISKOVICH, Jeffry, Bernard , GOODSON, Theodore, Junior , HALL, Steven, Edward , HERRON, David, Kent , KLIMKOWSKI, Valentine, Joseph , KYLE, Jeffrey, Alan , MASTERS, John, Joseph , MENDEL, David , MILOT, Guy , SAWYER, Jason, Scott , SHUMAN, Robert, Theodore , SMITH, Gerald, Floyd , TEBBE, Anne, Louise , TINSLEY, Jennifer, Marie , WEIR, Leonard, Crayton , WIKEL, James, Howard , WILEY, Michael, Robert
IPC分类号： A61K31/40 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/505 , C07D209/04 , C07D209/12 , C07D209/18 , C07D231/56 , C07D209/08 , C07D235/08 , C07D249/18 , C07D409/12 , C07D403/12 , C07D401/12 , C07D209/30 , C07D403/14 , C07D401/14
CPC分类号： C07D401/14 , C07D209/08 , C07D209/30 , C07D231/56 , C07D235/06 , C07D401/12 , C07D403/12 , C07D409/12
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公开(公告)号：EP1039911B1
公开(公告)日：2005-05-25
申请号：EP98955125.4
申请日：1998-10-26
IPC分类号： C07D209/22 , A61K31/535 , A61P29/00
CPC分类号： C07D209/42
摘要： The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid morpholino-N-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
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33.发明公开TERACYCLIC CARBAZOLE DERIVATES AND THEIR USE AS SPLA2 INHIBITORS 审中-公开TERACYCLISCHE咔唑衍生物及其作为sPLA2抑制剂使用
公开(公告)号：EP1345898A2
公开(公告)日：2003-09-24
申请号：EP01987004.7
申请日：2001-12-06
发明人： BEIGHT, Douglas, Wade , KINNICK, Michael, Dean , LIN, Ho-Shen , MORIN, John, Michael, Junior , RICHETT, Michael, Enrico , SALL, Daniel, Jon , SAWYER, Jason, Scott
IPC分类号： C07D209/80 , A61K31/40 , A61P43/00 , C07D209/94
CPC分类号： C07D209/80 , C07D209/94
摘要： A novel class of tetracyclic compounds is disclosed represented by the formula (I), or a pharmaceutically acceptable salt, solvate, or prodrug derivative thereof; wherein; A is independently C, or N; n is 1, 2 or 3; together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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公开(公告)号：EP1231938A2
公开(公告)日：2002-08-21
申请号：EP00978535.3
申请日：2000-11-09
发明人： FLEISCH, Jerome, Herbert , BENJAMIN, Roger, Stuart , SAWYER, Jason, Scott , TEICHER, Beverly, Ann , BEIGHT, Douglas, Wade , SMITH, Edward, C., R. , MCMILLEN, William, Thomas
摘要： Leukotriene (LTB4) antagonists enhance the effectiveness of 2',2'-difluoronucleoside anti-cancer agents.
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公开(公告)号：EP1039911A1
公开(公告)日：2000-10-04
申请号：EP98955125.4
申请日：1998-10-26
IPC分类号： A61K31/535 , C07D413/12
CPC分类号： C07D209/42
摘要： The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid morpholino-N-ethyl ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
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公开(公告)号：EP2155735A2
公开(公告)日：2010-02-24
申请号：EP08755094.3
申请日：2008-05-07
发明人： BROOKS, Harold, Burns , CRICH, Joyce, Z. , HENRY, James, Robert , HU, Hong , JIANG, Delu , LI, Hong-Yu , MANIAR, Sachin, Govindlal , MCMILLEN, William, Thomas , SAWYER, Jason, Scott , SLATER, Melissa, Kate , WANG, Yan
IPC分类号： C07D409/14 , A61K31/506 , A61P35/00
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
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公开(公告)号：EP1358156B1
公开(公告)日：2007-02-21
申请号：EP01993161.7
申请日：2001-12-06
发明人： BEIGHT, Douglas, Wade , KINNICK, Michael, Dean , LIN, Ho-Shen , MORIN, John, Michael, Junior , RICHETT, Michael, Enrico , SALL, Daniel, Jon , SAWYER, Jason, Scott , SMITH, Edward, C R
IPC分类号： C07D209/60 , A61K31/403 , A61P43/00
CPC分类号： C07D209/60
摘要： A novel class of benz[g]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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公开(公告)号：EP1349836B1
公开(公告)日：2006-06-14
申请号：EP01987005.4
申请日：2001-12-06
发明人： BEIGHT, Douglas, Wade , JANDZINSKI, John, David , KINNICK, Michael, Dean , LIN, Ho-Shen , MORIN, John, Michael, Junior , RICHETT, Michael, Enrico , SALL, Daniel, Jon , SAWYER, Jason, Scott
IPC分类号： C07D209/80 , A61K31/407 , C07D495/14 , A61P29/00
CPC分类号： C07D209/80 , C07D495/14
摘要： A novel class of tetracyclic compounds of formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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公开(公告)号：EP1578749A2
公开(公告)日：2005-09-28
申请号：EP03768530.2
申请日：2003-11-10
发明人： SAWYER, Jason, Scott
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： The disclosed invention relates to compounds of the formula (1), and the pharmaceutically acceptable salts thereof.
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公开(公告)号：EP1565471A1
公开(公告)日：2005-08-24
申请号：EP03768531.0
申请日：2003-11-10
IPC分类号： C07D487/04 , A61K31/4162 , A61K31/4709 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4709
摘要： A compound according to formula II and the pharmaceutically acceptable salts thereof and the method of treating cancer in a patient in need thereof by administration of said compound.
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