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1.发明授权[4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES 有权4-（苯并[b]噻吩-2-基）嘧啶-2-基] - 胺衍生物作为IKK-β抑制剂是治疗癌症和炎性疾病的治疗
公开(公告)号：EP1989200B1
公开(公告)日：2009-07-29
申请号：EP06850430.7
申请日：2006-11-15
发明人： DAHNKE, Karl, Robert , LIN, Ho-shen , SHIH, Chuan , WANG, Q, May , ZHANG, Bo , RICHETT, Michael, Enrico
IPC分类号： C07D409/04 , A61K31/506 , A61P33/00 , A61P19/02 , A61P11/00
CPC分类号： C07D409/04
摘要： The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
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公开(公告)号：EP1250340B1
公开(公告)日：2004-11-17
申请号：EP00986242.6
申请日：2000-12-11
发明人： BONJOUKLIAN, Rosanne , COHEN, Jeffrey, Daniel , GRUBER, Joseph, Michael , JOHNSON, Douglas, Webb , JUNGHEIM, Louis, Nickolaus , KROIN, Julian, Stanley , LANDER, Peter, Ambrose , LIN, Ho-Shen , LOHMAN, Mark, Christopher , MUEHL, Brian, Stephen , NORMAN, Bryan, Hurst , PATEL, Vinod, Francis , RICHETT, Michael, Enrico , THRASHER, Kenneth, Jeff , VEPACHEDU, Sreenivasarao , WHITE, Wesley, Todd , XIE, Yongping , YORK, Jeremy Schulenburg , PARKHURST, Brandon, Lee , WANG, Quiping
IPC分类号： C07D498/04 , A61K31/47 , A61P35/00 , A61P43/00
CPC分类号： C07D471/04
摘要： The present invention further relates to a method of inhibiting MRP1 in a mammal which comprises administering to a mammal in need thereof an effective amount of a compound of formula (I).
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公开(公告)号：EP1395554A1
公开(公告)日：2004-03-10
申请号：EP02709779.9
申请日：2002-03-15
IPC分类号： C07D209/88 , A61K31/403 , A61P29/00 , C07D409/04 , C07D401/04 , C07D405/04
CPC分类号： C07D403/12 , A61K31/403 , C07D209/88 , C07D409/04 , Y02A50/401
摘要： Carbazoles of formula (I) with R 2 =hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
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公开(公告)号：EP1349836A2
公开(公告)日：2003-10-08
申请号：EP01987005.4
申请日：2001-12-06
发明人： BEIGHT, Douglas, Wade , JANDZINSKI, John, David , KINNICK, Michael, Dean , LIN, Ho-Shen , MORIN, John, Michael, Junior , RICHETT, Michael, Enrico , SALL, Daniel, Jon , SAWYER, Jason, Scott
IPC分类号： C07D209/80 , A61K31/407 , C07D495/14 , A61P29/00
CPC分类号： C07D209/80 , C07D495/14
摘要： A novel class of tetracyclic compounds of formula (I) is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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5.发明公开HYDROXYFUNCTIONAL AMIDE 1H-INDOLE DERIVATIVES ACTIVE AS SPLA2 INHIBITORS 有权AMID活性作为sPLA 2抑制剂羟基-1H-吲哚衍生物
公开(公告)号：EP1220839A2
公开(公告)日：2002-07-10
申请号：EP00959170.2
申请日：2000-09-07
IPC分类号： C07D209/22 , A61K31/404 , A61P29/00
CPC分类号： C07D209/22
摘要： A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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6.发明公开[4-(BENZO[B]THIOPHEN-2-YL)-PYRIMIDIN-2-YL]-AMINE DERIVATIVES AS IKK-BETA INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES 有权4-（苯并[b]噻吩-2-基）嘧啶-2-基] - 胺衍生物作为IKK-β抑制剂是治疗癌症和炎性疾病的治疗
公开(公告)号：EP1989200A2
公开(公告)日：2008-11-12
申请号：EP06850430.7
申请日：2006-11-15
发明人： DAHNKE, Karl, Robert , LIN, Ho-shen , SHIH, Chuan , WANG, Q, May , ZHANG, Bo , RICHETT, Michael, Enrico
IPC分类号： C07D409/04 , A61K31/506 , A61P33/00 , A61P19/02 , A61P11/00
CPC分类号： C07D409/04
摘要： The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
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公开(公告)号：EP1565438B1
公开(公告)日：2007-10-17
申请号：EP03783127.8
申请日：2003-11-13
IPC分类号： C07D209/08 , C07D307/79 , C07D333/54 , C07D317/62 , C07D319/18 , C07C311/51 , A61K31/18 , A61P35/00 , C07D277/64
CPC分类号： C07D307/79 , C07C311/51 , C07C2602/06 , C07C2602/08 , C07D209/08 , C07D209/30 , C07D277/64 , C07D317/44 , C07D317/62 , C07D319/18 , C07D333/54 , C07D495/04
摘要： The present invention provides antitumor compounds of the formula (I); and antitumor methods.
摘要翻译： 本发明提供了式（I）的抗肿瘤化合物; 和抗肿瘤方法。
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公开(公告)号：EP1202963B1
公开(公告)日：2007-01-03
申请号：EP00944673.3
申请日：2000-07-11
IPC分类号： C07D209/22 , A61K31/40
CPC分类号： C07D209/22
摘要： A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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公开(公告)号：EP1358156A2
公开(公告)日：2003-11-05
申请号：EP01993161.7
申请日：2001-12-06
发明人： BEIGHT, Douglas, Wade , KINNICK, Michael, Dean , LIN, Ho-Shen , MORIN, John, Michael, Junior , RICHETT, Michael, Enrico , SALL, Daniel, Jon , SAWYER, Jason, Scott , SMITH, Edward, C R
IPC分类号： C07D209/60 , A61K31/403 , A61P43/00
CPC分类号： C07D209/60
摘要： A novel class of benz[g]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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公开(公告)号：EP1248769A2
公开(公告)日：2002-10-16
申请号：EP01918984.4
申请日：2001-01-05
IPC分类号： C07D209/88 , A61K31/403 , A61P43/00
CPC分类号： C07D209/88
摘要： A class of novel indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
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