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公开(公告)号：EP1252297A1
公开(公告)日：2002-10-30
申请号：EP01914330.4
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel colorectal cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'colorectal cancer antigens', and the use of such colorectal cancer antigens for detecting disorders of the colon and/or rectum particularly the presence of colorectal cancer and colorectal cancer metastases. More specifically, isolated colorectal cancer associated nucleic acid molecules are provided encoding novel colorectal cancer associated polypeptides. Novel colorectal cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human colorectal cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the colon and/or rectum including colorectal cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1252290A1
公开(公告)日：2002-10-30
申请号：EP01908617.2
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel connective tissue related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'connective tissue antigens', and the use of such connective tissue antigens for detecting disorders of connective tissue(s), particularly the presence of cancer and cancer metastases. More specifically, isolated connective tissue associated nucleic acid molecules are provided encoding novel connective tissue associated polypeptides. Novel connective tissue polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human connective tissue associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to connective tissue(s), including cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonsits of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新的结缔组织相关多核苷酸和由本文统称为“结缔组织抗原”的这些多核苷酸编码的多肽，以及此类结缔组织抗原用于检测结缔组织病症，特别是癌症的存在 和癌症转移。 更具体而言，提供了编码新型结缔组织相关多肽的分离的结缔组织相关核酸分子。 提供了新颖的结缔组织多肽和结合这些多肽的抗体。 还提供了载体，宿主细胞以及用于产生人结缔组织相关多核苷酸和/或多肽的重组和合成方法。 本发明还涉及用于诊断，治疗，预防和/或预测与结缔组织相关的疾病（包括癌症）的诊断和治疗方法，以及用于治疗这些疾病的治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。
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公开(公告)号：EP1261742A2
公开(公告)日：2002-12-04
申请号：EP01916069.6
申请日：2001-01-17
摘要： The present invention relates to novel immune/hematopoietic-related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'immune/hematopoietic antigens', and the use of such immune/hematopoietic antigens for detecting immune/hematopoietic-related diseases and/or disorders, particularly the presence of cancer and cancer metastases of cells of hematopoietic origin. More specifically, isolated immune/hematopoietic associated nucleic acid molecules are provided encoding novel immune/hematopoietic associated polypeptides. Novel immune/hematopoietic polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human immune/hematopoietic associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the immune system or cells and tissues associated with hematopoiesis, including cancers of cells of hematopoietic origin, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1261703A1
公开(公告)日：2002-12-04
申请号：EP01912655.6
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel musculoskeletal system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as ' musculoskeletal system antigens', and the use of such musculoskeletal system antigens for detecting disorders of the musculoskeletal system, particularly the presence of cancer and cancer metastases. More specifically, isolated musculoskeletal system associated nucleic acid molecules are provided encoding novel musculoskeletal system associated polypeptides. Novel musculoskeletal system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human musculoskeletal system associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the musculoskeletal system, including cancer of musculoskeletal tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1261618A2
公开(公告)日：2002-12-04
申请号：EP01912657.2
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel kidney related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'kikdney antigens', and the use of such kidney antigens for detecting disorders of the kidney, particularly the presence of kidney cancer and kidney cancer metastases. More specifically, isolated kidney associated nucleic acid molecules are provided encoding novel kidney associated polypeptides. Novel kidney polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human kidney associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the kidney, including kidney cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新的肾相关多核苷酸和由本文统称为“kikdney抗原”的这些多核苷酸编码的多肽，以及此类肾抗原用于检测肾病，特别是肾癌和肾癌转移的存在的用途。 更具体而言，提供了编码新型肾相关多肽的分离的肾相关核酸分子。 提供了新的肾多肽和结合这些多肽的抗体。 还提供了载体，宿主细胞以及用于产生人肾相关多核苷酸和/或多肽的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与肾相关的病症（包括肾癌）的诊断和治疗方法，以及用于治疗此类病症的治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。
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公开(公告)号：EP1261380A1
公开(公告)日：2002-12-04
申请号：EP01912649.9
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新蛋白质。 更具体而言，提供了编码新多肽的分离的核酸分子。 提供了与这些多肽结合的新多肽和抗体。 还提供了载体，宿主细胞以及用于生产人多核苷酸和/或多肽和抗体的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。
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公开(公告)号：EP1259540A1
公开(公告)日：2002-11-27
申请号：EP01910331.6
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1259526A2
公开(公告)日：2002-11-27
申请号：EP01922230.6
申请日：2001-01-17
IPC分类号： C07H21/02 , C07H21/04 , C07K5/00 , C07K14/00 , C12Q1/68 , C12P21/06 , C12N1/20 , C12N15/63 , C12N5/00
CPC分类号： Y02A50/475
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
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公开(公告)号：EP1255869A1
公开(公告)日：2002-11-13
申请号：EP01916067.0
申请日：2001-01-17
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifiying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新蛋白质。 更具体而言，提供了编码新多肽的分离的核酸分子。 提供了与这些多肽结合的新多肽和抗体。 还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。
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公开(公告)号：EP1255817A1
公开(公告)日：2002-11-13
申请号：EP01916068.8
申请日：2001-01-17
CPC分类号： Y02A50/475
摘要： The present invention relates to novel liver related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'liver antigens', and the use of such liver antigens for detecting disorders of the liver, particularly the presence of cancer of liver and cancer metastases. More specifically, isolated liver associated nucleic acid molecules are provided encoding novel liver associated polypeptides. Novel liver polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human liver associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the liver, including cancer of liver tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及新的肝脏相关多核苷酸和由本文统称为“肝脏抗原”的这些多核苷酸编码的多肽，以及此类肝脏抗原用于检测肝脏病症，特别是肝脏癌症和癌症转移的存在的用途。 更具体地说，提供了编码新型肝脏相关多肽的分离的肝脏相关核酸分子。 提供了新的肝脏多肽和结合这些多肽的抗体。 还提供了载体，宿主细胞以及用于生产人肝相关多核苷酸和/或多肽的重组和合成方法。 本发明进一步涉及用于诊断，治疗，预防和/或预测与肝有关的病症（包括肝组织癌）的诊断和治疗方法，以及用于治疗此类病症的治疗方法。 本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。
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