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公开(公告)号:EP2906253A1
公开(公告)日:2015-08-19
申请号:EP13795435.0
申请日:2013-10-11
CPC分类号: A61K31/5517 , A61K45/06 , A61K47/6803 , A61K47/6869 , C07K16/18
摘要: Conjugates of an antibody that binds to PSMA with PBD dimers.
摘要翻译: 与PSMA结合的抗体与PBD二聚体的缀合物。
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公开(公告)号:EP3612537A1
公开(公告)日:2020-02-26
申请号:EP18718452.8
申请日:2018-04-18
申请人: Medimmune Limited
IPC分类号: C07D519/00 , A61P35/00 , A61K47/68 , C07K5/062
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公开(公告)号:EP3054989B1
公开(公告)日:2019-03-27
申请号:EP14792406.2
申请日:2014-10-10
申请人: MedImmune Limited
IPC分类号: A61K47/68 , A61P35/00 , C07D519/00 , C07D487/04
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公开(公告)号:EP2906248B1
公开(公告)日:2018-12-05
申请号:EP13780099.1
申请日:2013-10-11
申请人: MedImmune Limited
IPC分类号: A61K47/68 , A61P39/00 , A61P35/00 , C07D487/04 , C07D519/00
CPC分类号: A61K47/6803 , A61K47/6855 , C07D487/04 , C07D519/00
摘要: A compound which is selected from A: B: and C: and salts and solvates thereof, as well as conjugates thereof with cell binding agent.
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36.
公开(公告)号:EP2751120B1
公开(公告)日:2018-08-22
申请号:EP12781045.5
申请日:2012-09-20
申请人: MedImmune Limited
IPC分类号: C07D519/00
CPC分类号: C07D487/04 , A61K47/54 , A61K47/55 , A61K47/60 , C07D519/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/06078 , C07K5/06156 , C07K5/06165
摘要: A compound with the formula I wherein: R2 is of formula II where Q is selected from OH, SH and NRN, and RN is selected from H, methyl and ethyl, as well as drug-linkers and drug-conjugates made from this compound.
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公开(公告)号:EP2906296B1
公开(公告)日:2018-03-21
申请号:EP13785373.5
申请日:2013-10-11
CPC分类号: A61K47/6849 , A61K31/5517 , A61K45/06 , A61K47/6803 , C07K16/2866 , C07K2317/565
摘要: Conjugates of an antibody that binds to CD25 with PBD dimers.
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公开(公告)号:EP3283121A1
公开(公告)日:2018-02-21
申请号:EP16716586.9
申请日:2016-04-15
CPC分类号: C07K16/2863 , A61K47/6803 , A61K47/6851 , A61K47/6867 , A61P35/00 , C07K2317/24 , Y02P20/55
摘要: The present disclosure relates to humanized anti-Axl antibodies and conjugates thereof. Conjugates comprising pyrroiobenzodiazepines (PBDs) having a labile protecting group in the form of a linker to the antibody are described.
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公开(公告)号:EP3283120A1
公开(公告)日:2018-02-21
申请号:EP16716585.1
申请日:2016-04-15
申请人: Medimmune Limited
CPC分类号: A61K47/6803 , A61K47/6867 , A61P35/00 , C07K16/2896 , Y02P20/55
摘要: Site-specific antibody-drug conjugates are described, in particular conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.
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公开(公告)号:EP3283118A1
公开(公告)日:2018-02-21
申请号:EP16716583.6
申请日:2016-04-15
CPC分类号: A61K47/6803 , A61K39/44 , A61K47/6869 , A61P35/00 , C07K16/30 , C07K16/3069 , Y02P20/55
摘要: Site-specific antibody-drug conjugates are described, in particular conjugates comprising an antibody which binds PSMA, and which comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antiobody moiety, allows for improved safety and efficacy of the ADC.
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