公开(公告)号：EP3878457A1

公开(公告)日：2021-09-15

申请号：EP19881272.9

申请日：2019-11-07

申请人： National University Corporation Kagawa University

发明人： MURAO, Koji ,  IMACHI, Hitomi ,  IZUMORI, Ken ,  YOSHIHARA, Akihide

IPC分类号： A61K31/7004 ,  A23L33/125 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00

摘要： To provide a brown and beige adipocyte activating agent and a brown and beige adipocyte activating food, each containing D-allulose as an active ingredient. Provided are a brown and beige adipocyte activating agent containing D-allulose as an active ingredient; a brown and beige adipocyte activating agent containing at least D-allulose and having a UCP-1 expression promoting action; a brown and beige adipocyte activating agent which enhances UCP-1 expression and thereby activates brown and beige adipocytes; an energy consumption promoting agent containing D-allulose as an active ingredient; an energy consumption promoting agent which activates brown and beige adipocytes and thereby promotes energy consumption; a UCP-1 expression enhancing agent containing D-allulose as an active ingredient; and a composition or food composition containing these agents.

公开(公告)号：EP1860195A1

公开(公告)日：2007-11-28

申请号：EP06715211.6

申请日：2006-03-03

申请人： National University Corporation Kagawa University

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  TAKADA, Goro ,  MORIMOTO, Kenji

IPC分类号： C12P19/02 ,  C12P19/24 ,  C12R1/38

CPC分类号： C12P19/02 ,  C12P19/24

摘要： Disclosed is a process for producing a crystalline sugar comprising D-psicose and D-allose. Also disclosed is a process for producing the sugar.
A complex crystalline sugar comprising D-psicose and D-allose. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.

摘要翻译： 公开了一种用于生产结晶糖包括D-阿洛酮糖和D-阿洛糖的方法。 所以光盘游离缺失是生产糖的过程。 一个复杂的结晶糖包括D-阿洛酮糖和D-阿洛糖。 在糖D-阿洛酮糖和D-阿洛糖之间的组成比为约1：1至1：4。 一种用于制造复杂的结晶糖包括D-阿洛酮糖和D-阿洛糖方法，该方法包括产生一个复杂的结晶糖含D-阿洛酮糖和对阿洛糖包括D-阿洛酮糖和D-阿洛从糖溶液和收集所述复合物结晶 糖。 在生产复杂的结晶糖的使用的糖溶液的溶剂是水，或水和乙醇的混合物。 含有D-阿洛酮糖和D-阿洛糖溶液是通过包括使D-阿洛酮糖与L-鼠李糖异构酶到D-阿洛酮糖转化为D-阿洛糖的方法生产。 L-鼠李糖异构酶源自属于施氏假单胞菌的菌株（IPOD FERM BP-08593）来源的。

公开(公告)号：EP1538200A1

公开(公告)日：2005-06-08

申请号：EP03752940.1

申请日：2003-05-22

申请人： Fushimi Pharmaceutical Company, Limited ,  Teikoku Seiyaku Co., Ltd. ,  Kagawa University ,  Shikoku Research Institute Incorporated ,  KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

发明人： IZUMORI, Ken ,  TOKUDA, Masaaki ,  ITANO, Toshifumi ,  MIYAMOTO, Osamu ,  ISHIDA, Toshihiko ,  MURAO, Koji ,  TASAKA, Taizo ,  MUNEUCHI, Gan ,  YAMAGUCHI, Fuminori ,  TANAKA, Terukazu ,  HOSSAIN, Mohammad, Akram ,  UEKI, Masaaki ,  HIROOKA, Kazuyuki ,  TAMINATO, Tomohiko ,  TSUSAKI, Keiji ,  TAKAHASHI, Takeo ,  NAGATA, Mitsuhiro ,  ISHIDA, Yutaka

IPC分类号： C12N5/08 ,  A23L1/30 ,  A61K7/00 ,  A61K31/7004

CPC分类号： A61Q19/00 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A61K8/60 ,  A61K31/7004

摘要： A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

摘要翻译： 利用一种罕见糖的生理活性的方法，worin生理活性敏感细胞与罕见糖处理，以改变细胞的功能。 被引入生理活性敏感的细胞，并且对修饰细胞功能的影响包含组合物，如在，稀有糖类活性成分全部。 该细胞是人类细胞。 该组合物是一种功能性食品，药物或化妆品。 稀有糖类是属于醛糖和/或酮糖罕见的糖。 醛糖是D-阿洛糖，并将细胞选自癌细胞增殖抑制活性敏感的细胞和活性氧产生抑制活性敏感的细胞的选择。 所述酮糖是D-阿洛酮糖，并且所述细胞选自趋化因子分泌的抑制活性敏感的细胞，小神经胶质细胞迁移抑制活性敏感的细胞，和低血糖活性敏感的细胞的选择。

公开(公告)号：EP4338598A1

公开(公告)日：2024-03-20

申请号：EP21939592.8

申请日：2021-05-07

申请人： National University Corporation Kagawa University

发明人： AKIMITSU, Kazuya ,  IZUMORI, Ken ,  YOSHIHARA, Akihide ,  TAKAOKA, Seizo ,  KATO, Shiro ,  MOCHIZUKI, Susumu

IPC分类号： A23L27/00 ,  A23L27/30 ,  A23L33/10

摘要： Object is to mass-produce a sweetener containing D-allulose and having a sweetness degree and taste quality very close to those of sugar at a world scale and at a low cost with price competitiveness. Provided is a mass-production method of a sweetener having functionality of D-allulose and a taste quality close to that of sugar, including acting D-allulose 3-epimerase on a D-glucose- and D-fructose-containing inexpensive composition used as a raw material, allowing isomerization of D-fructose in the raw material to proceed by an isomerization reaction between D-fructose and rare sugar D-allulose, terminating the reaction at the stage when a rare sugar D-allulose content reaches an intended content of an intended product, and thus obtaining an intended product composed of rare sugar D-allulose, D-glucose, and D-fructose, in which the D-fructose content is in a range that compensates for a weak point of D-allulose in sweetness degree and gives a taste quality close to that of sugar in cooperation with D-allulose and D-glucose.

公开(公告)号：EP4130278A1

公开(公告)日：2023-02-08

申请号：EP21773444.1

申请日：2021-03-26

申请人： National University Corporation Kagawa University

发明人： AKIMITSU, Kazuya ,  IZUMORI, Ken ,  YOSHIHARA, Akihide ,  KATO, Shiro ,  MOCHIZUKI, Susumu ,  YOSHIDA, Hiromi ,  KAMITORI, Shigehiro

IPC分类号： C12N15/61 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/90 ,  C12N11/082 ,  C12N15/63 ,  C12P19/24

摘要： A highly safe, highly active, and heat-resistant L-rhamnose isomerase and an amino acid-substituted mutant thereof, a microorganism producing them, or a method for producing an aldose or a ketose are provided, all of which are capable of being used in the food industry.
L-Rhamnose isomerase, which is capable of being obtained from a microorganism belonging to the genus Erwinia, has a 48 kDa subunit molecular mass measured by SDS-PAGE, and has the following substrate specificities (A) and (B).
(A) An isomerase activity of recognizing and reacting with a CHO group of C1 and an OH group of C2 of an aldose to convert the CHO group of C1 to an OH group and the OH group of C2 to a CO group, alternatively, recognizing and reacting with an OH group of C1 and a CO group of C2 of a ketose to convert the OH group of C1 to a CHO group and the CO group of C2 to an OH group.
(B) An activity of catalyzing an isomerization reaction between L-rhamnose and L-rhamnulose, between L-lyxose and L-xylulose, between L-mannose and L-fructose, between D-ribose and D-ribulose, between L-talose and L-tagatose, and between D-allose and D-allulose.

公开(公告)号：EP3950057A1

公开(公告)日：2022-02-09

申请号：EP20781293.4

申请日：2020-03-10

申请人： National University Corporation Kagawa University

发明人： MINAMINO, Tetsuo ,  OZAKI, Taro ,  YOSHIHARA, Akihide ,  IZUMORI, Ken

IPC分类号： A61P3/02 ,  A61P7/08 ,  A61P27/02 ,  A61P31/00 ,  A61K9/08 ,  A61K47/02 ,  A61K47/26

摘要： Provided is an improved glucose-containing peritoneal dialysate, an ophthalmic composition, or an infusion that can suppress a blood glucose level increase even when used in a long-term treatment and can also suppress an infectious disease, by only addition. A D-glucose-containing osmotic pressure regulator includes D-allose and/or D-allulose as an additive for suppressing a blood glucose level increase by continuous absorption of glucose into the body and for suppressing an infectious disease. The osmotic pressure regulator is used as a mixture with a peritoneal dialysate, an ophthalmic composition, or an infusion. A peritoneal dialysis method for suppressing a blood glucose level increase by continuous absorption of glucose into the body through peritoneal dialysis and for suppressing an infectious disease uses a dialysate containing D-allose and/or D-allulose in an effective amount.

公开(公告)号：EP3943078A1

公开(公告)日：2022-01-26

申请号：EP20771974.1

申请日：2020-01-23

申请人： National University Corporation Kagawa University

发明人： TAOKA, Rikiya ,  KAKEHI, Yoshiyuki ,  SUGIMOTO, Mikio ,  ZHANG, Xia ,  MATSUOKA, Yuki ,  IZUMORI, Ken ,  YOSHIHARA, Akihide

IPC分类号： A61K31/047 ,  A61K31/133 ,  A61K31/191 ,  A61K31/7004 ,  A61K45/00 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  A61K47/26 ,  A61K47/55

摘要： To provide a composition for the treatment of renal cell carcinoma and a composition or a method for enhancing the uptake of a drug into renal cell carcinoma cells. Provided are a D-allose-containing composition for the treatment of renal cell carcinoma, and a D-allose-containing composition or method for enhancing the uptake of a drug into renal cell carcinoma cells. The composition is a pharmaceutical composition to be administered in an effective amount to patients requiring the treatment of renal cell carcinoma in humans or animals other than humans.

公开(公告)号：EP3878966A1

公开(公告)日：2021-09-15

申请号：EP19881064.0

申请日：2019-11-07

申请人： National University Corporation Kagawa University

发明人： AKIMITSU, Kazuya ,  IZUMORI, Ken ,  TAKAOKA, Seizo ,  YOSHIHARA, Akihide ,  KATO, Shiro ,  MOCHIZUKI, Susumu

IPC分类号： C12P19/02 ,  A23L27/00 ,  C12N9/90 ,  C12N9/92

摘要： An object of the present invention is to provide a rare sugar-containing composition having improved properties as a sweetener while maintaining the excellent functionality of D-psicose. The invention relates to a method of producing a rare-sugar containing composition with D-fructose as a raw material. An intended product having a novel composition of D-glucose, D-fructose, and D-psicose is obtained by preparing a mixture of D-fructose and D-psicose by using ketose 3-epimerase in the first stage and converting D-fructose into D-glucose by using D-xylose isomerase inert to D-psicose in the second stage. The first-stage product is a mixture of D-fructose and rare sugar D-psicose. The resulting mixture is a sweetener having a taste quality equal to that of sugar.

公开(公告)号：EP2329713A1

公开(公告)日：2011-06-08

申请号：EP09808057.5

申请日：2009-08-18

申请人： Mitsui Chemicals Agro, Inc. ,  Shikoku Research Institute Incorporated ,  National University Corporation Kagawa University

发明人： OHARA, Toshiaki ,  ISHIDA, Yutaka ,  KUDOU, Rika ,  KAKIBUCHI, Kazumasa ,  AKIMITSU, Kazuya ,  IZUMORI, Ken ,  TAJIMA, Shigeyuki

IPC分类号： A01N35/02 ,  A01P3/00

CPC分类号： A01N43/16 ,  A01N37/34 ,  A01N37/36 ,  A01N43/36 ,  A01N43/40 ,  A01N43/50 ,  A01N43/54 ,  A01N47/12 ,  A01N47/34 ,  A01N47/44 ,  A01N59/20

摘要： Disclosed are: a plant disease control agent; and a plant disease control method. Specifically disclosed are: a plant disease control agent comprising D-tagatose as an active ingredient; and a plant disease control agent comprising at least one member selected from the group consisting of saccharides and substances each having a bactericidal and/or fungicidal activity. The plant disease control agents are effective for the control of cucumber, grape and cabbage downy mildew, damping-off in seedlings caused by Pythium spp, cucumber and barley powdery mildew, wheat stem rust, potato and tomato late blight, and others.

摘要翻译： 公开的是：一种植物病害防治剂; 和植物病害防治方法。 具体公开的是：含有D-塔格糖作为有效成分的植物病害防治剂; 以及包含选自由糖类和各自具有杀菌和/或杀真菌活性的物质组成的组中的至少一种的植物病害控制剂。 植物病害防治剂有效控制黄瓜，葡萄和卷心菜霜霉病，由腐霉属，黄瓜和大麦白粉病，小麦茎锈病，马铃薯和番茄晚疫病等引起的幼苗的阻遏。

公开(公告)号：EP1864669A1

公开(公告)日：2007-12-12

申请号：EP06729659.0

申请日：2006-03-22

申请人： National University Corporation Kagawa University

发明人： TOKUDA, Masaaki ,  MORIMOTO, Kenji ,  MATSUO, Tatsuhiro ,  IZUMORI, Ken ,  TAKEKAWA, Kaoru

IPC分类号： A61K31/7004

CPC分类号： A23K50/40 ,  A23K20/163 ,  A23L27/30 ,  A23L33/10 ,  A61K31/7004

摘要： A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

摘要翻译： 提供了D-psicose（用于抑制日内血糖水平升高异常）的新用途。 含有作为活性成分的D-灵芝蛋白的组合物，用于抑制血浆葡萄糖浓度的异常日增加。 组合物是与D-灵敏蛋白和/或其衍生物共混的组合物。 该组合物是选自甜味剂，调味料，食品添加剂，食品材料，食品和饮料产品，保健食品和饮料产品，药品和饲料中的形式，并且与D-灵芝蛋白和/或其衍生物作为活性物质 组分，用于预防和治疗需要节省胰岛素不足的疾病，改善胰岛素敏感性和改善高血糖症，和/或通过抑制日内异常升高可以改善症状的疾病 血浆葡萄糖浓度或通过其抑制如糖尿病，隐匿性糖尿病状态，肥胖症，高血糖症和/或动脉硬化可预防发作。 一种用于抑制血浆葡萄糖浓度异常日增加的方法，包括在给定时间给予D-psicose以抑制全天血浆葡萄糖浓度的异常增加。