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    Pharmaceutical containing episialo complex carbohydrate
    33.
    发明公开
    Pharmaceutical containing episialo complex carbohydrate 失效
    Arzneimittel enthaltend Episialo-Komplexe-Kohlenhydrate。

    公开(公告)号：EP0443518A2

    公开(公告)日：1991-08-28

    申请号：EP91102346.3

    申请日：1991-02-19

    申请人： MECT CORPORATION

    发明人： Nagai, Yoshitaka ,  Suda, Isao ,  Hino, Akihiro ,  Sugimoto, Mamoru ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： A61K31/70 ,  G01N33/574 ,  A61K39/00

    CPC分类号： A61K31/7004 ,  A61K31/70

    摘要： A drug for diagnosis using a serum sample, particularly a drug for diagnosis using a serum sample for the detection of cancer containing an episialo complex carbohydrate such as epiGM₃, epiGM₄ and epiGM₅, a cancer vaccine containing the episialo complex carbohydrate, a method for diagnosis using a serum sample, particularly a diagnostic method for the prevention and therapy of cancer are disclosed.

    摘要翻译： 用于使用血清样品进行诊断的药物，特别是用于使用血清样品进行诊断的药物，用于检测含有配体复合物碳水化合物如epiGM3，epiGM4和epiGM5的癌症药物，含有配体糖复合物的癌症疫苗，使用 公开了血清样品，特别是用于预防和治疗癌症的诊断方法。

    Use of N-methyl-sphingosine as inhibitor of cell growth
    34.
    发明公开
    Use of N-methyl-sphingosine as inhibitor of cell growth 失效
    作为细胞生长抑制剂的丝氨酸和N-甲基 - 丝胶蛋白

    公开(公告)号：EP0381514A3

    公开(公告)日：1991-07-17

    申请号：EP90301099.9

    申请日：1990-02-02

    申请人： The Biomembrane Institute ,  CORNELL RESEARCH FOUNDATION, INC. ,  MECT CORPORATION

    发明人： Igarashi, Yasuyuki ,  Toyokuni, Tatsushi ,  Hakomori, Sen-itiroh ,  Racker, Efraim, Department of Biochemistry ,  Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13

    摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

    Novel sphingenine and derivatives thereof
    35.
    发明公开
    Novel sphingenine and derivatives thereof 失效
    新型配体及其衍生物

    公开(公告)号：EP0372571A3

    公开(公告)日：1991-07-03

    申请号：EP89122689.6

    申请日：1989-12-08

    申请人： MECT CORPORATION

    发明人： Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： C07C69/18 ,  C07C43/15 ,  C07C309/66 ,  C07C247/08 ,  C07C233/18 ,  C07C217/46 ,  C07H15/10

    CPC分类号： C07C43/178 ,  C07C69/145 ,  C07C217/46 ,  C07C233/18 ,  C07C247/08

    摘要： A sphingenine and derivatives thereof herein provided are represented by the following general formulas (I) and (II):
    in the formulas (I) and (II), R 1 represents a hydrogen atom, an acetyl group or a methanesulfonyl group; R 2 represents a hydrogen atom or an ethoxyethyl group; R 3 represents an azido group, an amino group, an alkylamido group, an arylamido group, an aralkylamido group or a tetracosanamido group; R 4 represents a hydrogen atom or an ethoxyethyl group; EE represents an ethoxy ethyl group; and n is an integer ranging from 1 to 22. These sphingenine and derivatives thereof are very useful as intermediates for synthesizing glycolipids and gangliosides which are effective as markers of tumours, in particular, in the preparation of ceramide parts of the glycolipids and gangliosides.

    Sialosyl glyceride and process for producing the same
    36.
    发明公开
    Sialosyl glyceride and process for producing the same 失效
    硅藻糖及其生产方法

    公开(公告)号：EP0332191A3

    公开(公告)日：1990-05-16

    申请号：EP89104199.8

    申请日：1989-03-09

    申请人： MECT CORPORATION

    发明人： Yoshimura, Shoji ,  Matsuzaki, Yuzi ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： C07H5/06 ,  A61K31/70

    CPC分类号： C07H15/06

    摘要： The present application discloses a new sialosyl glyceride having the following formula, which compound is useful as a remedy for nervous diseases, has an excellent compatibility with the living bodies, and is easily producible.
    wherein R¹ represents a hydrogen atom or XCH₂CO- (X being a halogen atom), R² represents an alkali metal, a hydrogen atom or a lower alkyl group, R³ represents a hydrogen atom or -CO(CH₂)mCH₃, R⁴ represents -CO(CH₂)mCH₃ and m and n each represents a number of 0 to 30.