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63 条记录 (耗时 0.019 秒)

    Use of N-methyl-sphingosine as inhibitor of cell growth
    32.
    发明公开
    Use of N-methyl-sphingosine as inhibitor of cell growth 失效
    Verwendung von Sphingosin und N-Methyl-Sphingosin als Zell-Wachstums-Inhibitor。

    公开(公告)号：EP0381514A2

    公开(公告)日：1990-08-08

    申请号：EP90301099.9

    申请日：1990-02-02

    申请人： The Biomembrane Institute ,  CORNELL RESEARCH FOUNDATION, INC. ,  MECT CORPORATION

    发明人： Igarashi, Yasuyuki ,  Toyokuni, Tatsushi ,  Hakomori, Sen-itiroh ,  Racker, Efraim, Department of Biochemistry ,  Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13

    摘要： A medicament for inhibiting growth of human and animal cells comprising: (1) a cell growth inhibitory amount of a one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method for inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising synthetically prepared sphingosine, synthetically prepared N-methyl-sphingosine or pharmaceutically acceptable salts thereof. A medicament for inhibiting growth of human and animal cells comprising: (1) A cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof; and (2) a pharmaceutically acceptable carrier, diluent or excipient. A method of inhibiting growth of human and animal cells in vivo comprising contacting said cells with a cell growth inhibitory amount of one or more growth inhibitors comprising sphingosine prepared from naturally occurring sphingolipid, N-methyl-sphingosine prepared from naturally occurring sphingolipid or pharmaceutically acceptable salts thereof.

    摘要翻译： 一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。 一种用于抑制体内人和动物细胞生长的方法，包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包括合成制备的鞘氨醇，合成制备的N-甲基 - 鞘氨醇或其药学上可接受的盐。 一种用于抑制人和动物细胞生长的药物，包括：（1）细胞生长抑制量的一种或多种生长抑制剂，其包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或其药学上可接受的盐; 和（2）药学上可接受的载体，稀释剂或赋形剂。 一种在体内抑制人和动物细胞生长的方法，其包括使所述细胞与细胞生长抑制量的一种或多种生长抑制剂接触，所述生长抑制剂包含由天然存在的鞘脂制备的鞘氨醇，由天然存在的鞘脂制备的N-甲基 - 鞘氨醇或药学上可接受的盐 它们。

    Novel sphingenine and derivatives thereof
    34.
    发明公开
    Novel sphingenine and derivatives thereof 失效
    鞘氨醇和衍生物davon。

    公开(公告)号：EP0372571A2

    公开(公告)日：1990-06-13

    申请号：EP89122689.6

    申请日：1989-12-08

    申请人： MECT CORPORATION

    发明人： Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： C07C69/18 ,  C07C43/15 ,  C07C309/66 ,  C07C247/08 ,  C07C233/18 ,  C07C217/46 ,  C07H15/10

    CPC分类号： C07C43/178 ,  C07C69/145 ,  C07C217/46 ,  C07C233/18 ,  C07C247/08

    摘要： A sphingenine and derivatives thereof herein provided are represented by the following general formulas (I) and (II):

    in the formulas (I) and (II), R 1 represents a hydrogen atom, an acetyl group or a methanesulfonyl group; R 2 represents a hydrogen atom or an ethoxyethyl group; R 3 represents an azido group, an amino group, an alkylamido group, an arylamido group, an aralkylamido group or a tetracosanamido group; R 4 represents a hydrogen atom or an ethoxyethyl group; EE represents an ethoxy ethyl group; and n is an integer ranging from 1 to 22. These sphingenine and derivatives thereof are very useful as intermediates for synthesizing glycolipids and gangliosides which are effective as markers of tumours, in particular, in the preparation of ceramide parts of the glycolipids and gangliosides.

    摘要翻译： 本文提供的鞘氨醇及其衍生物由式（I）和（II）中的以下通式（I）和（II）表示：，式（I）和（II）中的R 1表示氢原子，乙酰基或 甲磺酰基; R 2表示氢原子或乙氧基乙基; R 3表示叠氮基，氨基，烷基酰氨基，芳基酰氨基，芳烷基酰氨基或四聚山酰胺基; R 4表示氢原子或乙氧基乙基; EE表示乙氧基乙基; n是1至22范围内的整数。这些鞘氨醇及其衍生物作为合成作为肿瘤标记有效的糖脂和神经节苷脂的中间体非常有用，特别是制备糖脂和神经节苷脂的神经酰胺部分。

    Sialosylceramides and production method thereof
    36.
    发明公开
    Sialosylceramides and production method thereof 失效
    唾液酸神经酰胺和Verfahren zu deren Herstellung。

    公开(公告)号：EP0242736A1

    公开(公告)日：1987-10-28

    申请号：EP87105321.1

    申请日：1987-04-10

    申请人： MECT CORPORATION

    发明人： Ogawa, Tomoya ,  Sugimoto, Mamoru ,  Numata, Masaaki ,  Shitori, Yoshiyasu ,  Ito, Masayoshi

    IPC分类号： C07H15/10

    CPC分类号： C07H15/10

    摘要： This invention provides a novel compound expressed by the following formula (l):
    [wherein R¹ denotes a hydrogen atom or CH₃CO-, R² denotes -COOR⁴ (R⁴ denotes Na or a methyl group) or
    (R⁵ denotes a hydrogen atom, -COC₆H₅ or -Si(C₆H₅)₂C(CH₃)₃ and R³ denotes
    (R⁵ denotes a hydrogen atom, -COC₆H₅ or -Si(C₆H₅)₂C(CH₃)₃) when R² is -COOR⁴ (R⁴ denotes Na or a methyl group) or denotes -COOR⁴ when R² is
    and a method of preparation thereof.
    The above novel compounds of present invention are useful as a tumor maker, a molecular marker for cells having the ability of differential induction, or an intermediate of the synthesis thereof.

    摘要翻译： 本发明提供由下式（I）表示的新化合物：其中R 1表示氢原子或CH 3 CO-，R 2表示-COOR 4（R 4表示Na或 甲基）或（R 5表示氢原子，-COC 6 H 5或-Si（C 6 H 5）2 C（CH 3）3，R 3表示CHEM（R 5表示氢原子， -COC6H5或-Si（C6H5）2C（CH3）3）当R 2为-COOR 4时（R 4表示Na或甲基）或表示-COOR 4，当R 2为 本发明的上述新化合物可用作肿瘤制造者，具有差异诱导能力的细胞的分子标记物或其合成中间体。

    Pharmaceutical containing episialo complex carbohydrate
    40.
    发明公开
    Pharmaceutical containing episialo complex carbohydrate 失效
    Arzneimittel enthaltend Episialo-Komplexe-Kohlenhydrate。

    公开(公告)号：EP0443518A2

    公开(公告)日：1991-08-28

    申请号：EP91102346.3

    申请日：1991-02-19

    申请人： MECT CORPORATION

    发明人： Nagai, Yoshitaka ,  Suda, Isao ,  Hino, Akihiro ,  Sugimoto, Mamoru ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： A61K31/70 ,  G01N33/574 ,  A61K39/00

    CPC分类号： A61K31/7004 ,  A61K31/70

    摘要： A drug for diagnosis using a serum sample, particularly a drug for diagnosis using a serum sample for the detection of cancer containing an episialo complex carbohydrate such as epiGM₃, epiGM₄ and epiGM₅, a cancer vaccine containing the episialo complex carbohydrate, a method for diagnosis using a serum sample, particularly a diagnostic method for the prevention and therapy of cancer are disclosed.

    摘要翻译： 用于使用血清样品进行诊断的药物，特别是用于使用血清样品进行诊断的药物，用于检测含有配体复合物碳水化合物如epiGM3，epiGM4和epiGM5的癌症药物，含有配体糖复合物的癌症疫苗，使用 公开了血清样品，特别是用于预防和治疗癌症的诊断方法。