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公开(公告)号：EP3733196B1
公开(公告)日：2023-08-30
申请号：EP18845399.7
申请日：2018-12-21
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公开(公告)号：EP3733196A1
公开(公告)日：2020-11-04
申请号：EP18845399.7
申请日：2018-12-21
发明人： DOMÍNGUEZ HORTA, María del Carmen , LOPEZ ABAD, Cruz Matilde , GONZÁLEZ LÓPEZ, Luis Javier , BESADA PÉREZ, Vladimir Armando
摘要： The invention is relate with a pharmaceutical composition comprising peptide type APL called identified as SEQ ID No. 1, sodium acetate buffer at pH 3.9 - 4.7; and at least one stabilizing sugar selected from sucrose or trehalose. This pharmaceutical composition is useful for manufacture of a medicament for treating inflammatory diseases related to an increase of neutrophils or citrullination of proteins. These inflammatory diseases include rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS), Alzheimer's disease, and hepatic and pulmonary fibrosis. The invention also discloses a method for the treatment of these diseases, through effective therapeutic administration of the pharmaceutical composition of APL-type peptide.
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33.发明授权
公开(公告)号：EP2022506B1
公开(公告)日：2017-10-11
申请号：EP07721810.5
申请日：2007-04-26
发明人： HUERTA GALINDO, Vivian , CHINEA SANTIAGO, Glay , FLEITAS SALAZAR, Noralvis , MARTÍN DUNN, Alejandro, Miguel , SARRÍA NÚÑEZ, Mónica , GUIROLA CRUZ, Osmany , TOLEDO MAYORA, Patricia, Gabriela , SÁNCHEZ PUENTE, Aniel , BESADA PÉREZ, Vladimir, Armando , REYES ACOSTA, Osvaldo , GARAY PÉREZ, Hilda, Elisa , CABRALES RICO, Ania , MUSACCHIO LASA, Alexis , PADRÓN PALOMARES, Gabriel, Ramón , GONZÁLEZ LÓPEZ, Luis, Javier
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
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公开(公告)号：EP2647369B1
公开(公告)日：2017-01-25
申请号：EP11807854.2
申请日：2011-11-30
发明人： ESTRADA GARCÍA, Mario, Pablo , LUGO GONZÁLEZ, Juana, María , CARPIO GONZÁLEZ, Yamila , TAFALLA PIÑEIRO, Carolina
CPC分类号： A61K38/2278 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/5153 , A61K31/7056 , A61K38/22 , A61K2300/00
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35.发明公开CONJUGATE COMPRISING ERYTHROPOIETIN AND A BRANCHED POLYMER STRUCTURE 审中-公开KONJUGAT，MIT ERYTHROPOIETIN UND EINER VERZWEIGTEN POLYMERSTRUKTUR
公开(公告)号：EP3093024A1
公开(公告)日：2016-11-16
申请号：EP15705897.5
申请日：2015-01-08
发明人： PÁEZ MEIRELES, Rolando , AMARPO GONZÁLEZ, Daniel, Enrique , CASTRO ODIO, Fidel, Raúl , HERNÁNDEZ VALDES, Yenisel , RUIZ ESTRADA, Gladys, Amalia
CPC分类号： A61K47/48215 , A61K38/1816 , A61K47/60
摘要： The present invention discloses a conjugate comprising erythropoietin (EPO) and an asymmetric branched polymeric structure comprising two branches of monomethoxypolyethylene glycol (mPEG), where the molecular mass of one of these mPEG branches is between 10 kDa and 14 kDa, and the molecular mass of the other branch of mPEG is between 17 kDa and 23 kDa, as well as the pharmaceutical compositions containing it. The invention also provides a method for the preparation of pegylated EPO, wherein said protein is conjugated to an asymmetric branched polymeric structure with two branches of mPEG having the above described molecular masses.
摘要翻译： 本发明公开了一种包含红细胞生成素（EPO）和不对称支化聚合物结构的缀合物，其包含两个分支的单甲氧基聚乙二醇（mPEG），其中这些mPEG分支中的一个分子量在10kDa至14kDa之间，分子质量 mPEG的另一个分支是17kDa和23kDa之间，以及含有它的药物组合物。 本发明还提供了一种制备聚乙二醇化EPO的方法，其中所述蛋白质与具有上述分子量的两个具有mPEG分枝的不对称支化聚合物结构缀合。
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36.发明授权COMPOUNDS AND PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND ISCHEMIC BRAIN DISEASES 有权物质和神经变性的治疗药物组合物和局部缺血性脑功能障碍
公开(公告)号：EP2733149B1
公开(公告)日：2016-09-28
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/20 , A61K38/21 , A61K38/25 , C07K5/083 , C07K5/103 , C07K7/06
CPC分类号： A61K31/409 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/1816 , A61K38/2013 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/25 , A61K47/55 , C07K5/08 , C07K5/081 , C07K5/10 , C07K5/1008 , C07K7/06 , A61K2300/00 , A61K36/06
摘要： The present invention describes peptides comprising phycocyanobilin (PCB), as well as the medical use of said peptides and that of PCB, due to the neuroprotector and/or neuroregenerative effects identified for them. Furthermore, pharmaceutical combinations of said peptides and of PCB with proteins or other peptides with synergic effect justify their use for ischemic or neurodegenerative CNS disease treatment.
摘要翻译： 本发明描述的肽，其包括藻蓝胆素（PCB），以及医疗使用所述肽的和做PCB的，由于神经保护和/或识别为他们的神经再生的影响。 进一步，所述肽和与PCB或其它肽与协同作用的蛋白质的药物组合证明自己的局部缺血或神经变性疾病的CNS治疗用途。
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公开(公告)号：EP2623114B1
公开(公告)日：2016-05-11
申请号：EP11776064.5
申请日：2011-09-26
发明人： RODRIGUEZ MALLON, Alina , FERNANDEZ DIAZ, Erlinda , ESTRADA GARCIA, Mario, Pablo , CARPIO GONZALEZ, Yamila
IPC分类号： A61K39/00 , C07K14/435
CPC分类号： C07K14/43509 , A61K39/0003 , C07K14/43527
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公开(公告)号：EP1785143B1
公开(公告)日：2015-03-04
申请号：EP05779477.8
申请日：2005-08-29
发明人： MUSACCHIO LASA, Alexis , DUEÑAS CARRERA, Santiago c/o Centro de Ingenieria Genética y Biotecnologia , ALVAREZ-LAJONCHERE PONCE DE LEÓN, Liz , ACOSTA RIVERO, Nelson General Lee, No. 201 altos , MARTÍNEZ DONATO, Gillian Calle 186 , GUIROLA TSIBULOVA, María Cervantes, No. 35 A , SARDIÑAS GARCÍA, Gretel Jorge, No. 18
CPC分类号： A61K39/095 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , A61K2039/70 , C12N2710/24143 , C12N2730/10134 , C12N2770/24234
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39.发明公开METHOD FOR INDUCING RESISTANCE TO DISEASES IN PLANTS 有权富兰克兰VERFAHREN ZUR ERZEUGUNG VON KRANKHEITSRESISTENZ
公开(公告)号：EP2681997A1
公开(公告)日：2014-01-08
申请号：EP12719247.4
申请日：2012-02-27
发明人： BORRÁS HIDALGO, Orlando , CANALES LÓPEZ, Eduardo , PUJOL FERRER, Merardo , BORROTO NORDELO, Carlos, Guillermo , COLL GARCÍA, Yamilet
摘要： The present invention describes a method for the stimulation of the natural defense and the induction of resistance to diseases in plants by simultaneous activation of genes related to the route of the salicylic acid, the jasmonic acid/ethylene and the hypersensitive response. The invention also includes the use of brassinosteroids for the preventive and curative treatment against plant diseases caused by pathogens. In addition, includes a method for the prevention and treatment of the Huanglongbing disease in citrus.
摘要翻译： 本发明描述了通过同时激活与水杨酸，茉莉酸/乙烯和过敏反应的途径有关的基因来刺激自然防御和对植物疾病抗性的诱导的方法。 本发明还包括使用油菜素类固醇来预防和治疗由病原体引起的植物疾病。 另外还包括一种预防和治疗柑橘黄龙病的方法。
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40.发明授权DENGUE VIRUS CAPSID PROTEIN WHICH INDUCES A PROTECTIVE RESPONSE AND PHARMACEUTICAL COMPOSITION 有权登革病毒衣壳蛋白用于诱导保护性反应和药物组合物
公开(公告)号：EP1944038B1
公开(公告)日：2013-11-27
申请号：EP06791279.0
申请日：2006-09-18
发明人： LAZO VAZQUEZ, Laura , HERMIDA CRUZ, Lisset , LOPEZ ABARRATEGUI, Carlos , SIERRA VAZQUEZ, Beatriz de la Caridad , VAZQUEZ RAMUNDO, Susana , VALDEZ PRADO, Iris , GUILLEN NIETO, Gerardo, Enrique , GUZMAN TIRADO, María, Guadalupe , ZULUETA MORALES, Aída
IPC分类号： A61K39/12 , A61K39/295 , C07K14/18
CPC分类号： A61K39/12 , A61K2039/55505 , A61K2039/55566 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386
摘要： This invention describe the a pharmaceutical compound having the capsid protein of Dengue virus capable of induce in the receptor a protective immune response before the viral challenge without inducing the Abdependent enhancement phenomenon.
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