公开(公告)号：EP3656791A1

公开(公告)日：2020-05-27

申请号：EP18836123.2

申请日：2018-07-18

申请人： Kyowa Kirin Co., Ltd. ,  Kyoto University

发明人： KAI, Masayuki ,  OGAWA, Shinya ,  TAKETO, Makoto ,  KAWADA, Kenji ,  HIRAI, Hideyo ,  SAKAI, Yoshiharu ,  MAEKAWA, Taira

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N5/12 ,  C12N15/13 ,  C12P21/08 ,  G01N33/53

摘要： An object of the present invention is to provide a monoclonal antibody which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment there of. The present invention relates to a monoclonal antibody which binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15), or an antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment.

公开(公告)号：EP4353735A1

公开(公告)日：2024-04-17

申请号：EP22820270.1

申请日：2022-06-08

申请人： Mitsubishi Chemical Corporation ,  Kyowa Kirin Co., Ltd.

发明人： TASHIRO, Yoshiya ,  OHARA, Shouhei ,  TAKEHARA, Jun ,  ISHIHARA, Takashi ,  KIKUCHI, Shinsuke

IPC分类号： C07K1/22 ,  B01D15/00 ,  B01J20/28

CPC分类号： C07K1/22 ,  B01J20/28 ,  B01D15/00

摘要： A synthetic adsorbent,
wherein a maximum value of a differential pore volume (mL/g) under a pressure condition of 0.5 psia to 30.0 psia, which is measured by the following method, is greater than 0.05 mL/g,

1. a pressure in a sample container where the synthetic adsorbent that has been dried is placed is reduced to 10 Pa or less, mercury specified in JIS K 8572 is degassed by reducing the pressure to 10 Pa or less, and the sample container is filled with the mercury at a pressure of 0.5 psia,
2. a mercury intrusion amount when the pressure in the sample container filled with the mercury is stepwisely increased from 0.5 psia to 30.0 psia is measured, and
3. a differential pore volume (mL/g) is determined by dividing an amount of an increase in the mercury intrusion amount when a first-stage pressure calculated based on the mercury intrusion amount measured in the item 2 is increased, by a measured amount of the synthetic adsorbent.

公开(公告)号：EP2314686B2

公开(公告)日：2023-06-21

申请号：EP10180018.3

申请日：2001-10-05

发明人： Kanda, Yutaka ,  Satoh, Mitsuo ,  Nakamura, Kazuyasu ,  Uchida, Kazuhisa ,  Shinkawa, Toyohide ,  Yamane, Naoko ,  Hosaka, Emi ,  Yamano, Kazuya ,  Yamasaki, Motoo ,  Hanai, Nobuo

IPC分类号： C12N15/10 ,  C12P21/08 ,  C07K16/00 ,  A01K67/00 ,  A61K39/395 ,  C12N9/00 ,  C12N15/52 ,  G01N33/53

公开(公告)号：EP3513809B1

公开(公告)日：2022-03-02

申请号：EP17850954.3

申请日：2017-09-13

发明人： HANIUDA, Hiroki ,  ENOKIZONO, Sachiko ,  NAKAZATO, Tomoyuki ,  TOKUDA, Takuya ,  FUJIKI, Norie

IPC分类号： A61K45/00 ,  A61K9/08 ,  A61K31/4709 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K47/40 ,  A61P9/10 ,  A61P27/02 ,  A61K9/00

公开(公告)号：EP3270923B1

公开(公告)日：2021-05-26

申请号：EP16765135.5

申请日：2016-03-18

发明人： HORITA, Takako

IPC分类号： A61K31/4439 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28

公开(公告)号：EP3151859B1

公开(公告)日：2020-11-25

申请号：EP15806501.1

申请日：2015-05-29

申请人： Ultragenyx Pharmaceutical Inc. ,  Kyowa Kirin Co., Ltd.

发明人： KAKKIS, Emil ,  SAN MARTIN, Javier ,  SUDO, Tomohiro

IPC分类号： A61P19/08 ,  A61K39/395 ,  C07K14/50 ,  C07K16/22 ,  A61K39/00

公开(公告)号：EP3733693A1

公开(公告)日：2020-11-04

申请号：EP18897857.1

申请日：2018-12-27

申请人： Kyowa Kirin Co., Ltd.

发明人： IKEDA Masahiro ,  YAMAGUCHI Shinpei ,  MURAKAMI Masumi ,  ONODERA Hideyuki

IPC分类号： C07K14/55 ,  A61K38/20 ,  A61K47/54 ,  A61K47/60 ,  A61K47/61 ,  A61P37/04 ,  C12N5/0783

摘要： The purpose of the present invention is to provide a novel IL-2 variant that has an improved selectivity for IL-2R αβγ and selectively activates Treg. The present invention pertains to: an IL-2 variant; a method for producing the IL-2 variant; a composition containing the IL-2 variant; a therapeutic agent for an immunological disease containing the IL-2 variant; a method for elevating the selectivity of IL-2 for IL-2R αβγ ; a method for improving the affinity of IL-2 for IL-2Rα subunit; a method for lowering the affinity of IL-2 for IL-2Rβ and/or γ subunits; and a method for selectively activating a regulatory T cell.

公开(公告)号：EP3698799A1

公开(公告)日：2020-08-26

申请号：EP18869094.5

申请日：2018-10-16

申请人： FUJIFILM Corporation ,  Kyowa Kirin Co., Ltd.

发明人： TOKUOKA Shinsuke ,  YOSHIDA Hayato ,  KONDO Yuichiro

IPC分类号： A61K31/785 ,  A61P3/00 ,  A61P13/12

摘要： The object of the present invention is to provide a therapeutic agent for hyperphosphatemia capable sufficiently decreasing a serum phosphorus concentration with a small dose. The present invention provides a therapeutic agent for hyperphosphatemia, which comprises, as an active ingredient, a particle containing certain crosslinked polymer (preferably crosslinked polyallylamine).

公开(公告)号：EP3594345A1

公开(公告)日：2020-01-15

申请号：EP18764304.4

申请日：2018-03-07

申请人： Kyowa Kirin Co., Ltd.

发明人： MASUDA, Kazuhiro ,  YAMADA, Yoji ,  IWAI, Hiroto ,  ISODA, Yuya ,  PIAO, Wen

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K48/00 ,  A61P7/02 ,  A61P9/10 ,  A61P13/12

摘要： The present invention provides a nucleic acid having activity to suppress expression of MASP2, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as APS, SLE and the like and thrombosis in hemodialysis.

公开(公告)号：EP3508493B1

公开(公告)日：2024-10-02

申请号：EP17846649.6

申请日：2017-08-31

IPC分类号： C07K1/22 ,  C07K16/00 ,  C07K17/08 ,  B01D15/26

CPC分类号： C07K16/00 ,  C07K1/22 ,  C07K17/08 ,  B01D15/265