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31.发明公开IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN 有权体外评估根据测试心血管事件的新表位的肌联蛋白蛋白质
公开(公告)号：EP2731960A1
公开(公告)日：2014-05-21
申请号：EP12731501.8
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
摘要： A bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a titin protein by a proteinase comprises contacting a sample with an antibody specifically binding said neo-epitope and determining the level of binding. Partial sequences of titin that may be detected include: 3519' ↓GEYVCDCGTD '13528, 3532' NVTVEARLIK↓ '13542, 3543'↓VEKPLYGVEV '1553.
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公开(公告)号：EP2729578A1
公开(公告)日：2014-05-14
申请号：EP12733674.1
申请日：2012-07-04
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C12Q1/37 , G01N2333/47 , G01N2333/96486 , G01N2800/2821 , G01N2800/56
摘要： Provided herein is a method of bioassay for the quantification of peptide fragments relevant to neurodegenerative conditions. The method comprises cleaving a Tau protein by a secretase, such as ADAM10, to form a neo-epitope. The method comprises contacting a blood derived sample with an antibody specific for the neo-epitope and determining the level of binding of the antibody to peptide fragments comprising the neo-epitope in the sample. Neo-epitope containing peptide levels are found to be inversely correlated to cognitive function.
摘要翻译： 用于定量与神经变性病症相关的肽片段的生物测定方法包括通过分泌酶例如ADAM10切割Tau蛋白而形成的新表位，包括使血液衍生的样品与新表位特异的抗体接触并确定 所述免疫结合配偶体与所述样品中的肽片段的结合水平。 发现含有多肽水平的新表位与认知功能成反比。
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公开(公告)号：EP2405934B1
公开(公告)日：2014-03-26
申请号：EP10708193.7
申请日：2010-03-10
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公开(公告)号：EP2538221A3
公开(公告)日：2013-04-24
申请号：EP12185050.7
申请日：2008-11-04
发明人： Karsdal, Morten , Qvist, Per , Barascuk, Natasha
IPC分类号： G01N33/68 , C12Q1/37 , G01N33/542 , C07K14/47
CPC分类号： G01N33/6878 , C07K14/77 , C07K14/775 , C07K14/78 , C12Q1/37 , G01N33/542 , G01N33/577 , G01N33/6893 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is versican and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
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公开(公告)号：EP2563377A1
公开(公告)日：2013-03-06
申请号：EP11716413.7
申请日：2011-04-27
IPC分类号： A61K36/488 , A61P19/00
CPC分类号： A61K36/488
摘要： Excessive articular cartilage degradation is treated or prevented by administration to a mammal such as a human Pueraria lobata (Kudzu) root or an extract thereof.
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公开(公告)号：EP2538222A8
公开(公告)日：2013-02-27
申请号：EP12185053.1
申请日：2008-11-04
发明人： Karsdal, Morten , Qvist, Per , Barascuk, Natasha
IPC分类号： G01N33/68 , C07K14/47 , C12Q1/37 , G01N33/542
CPC分类号： G01N33/6878 , C07K14/77 , C07K14/775 , C07K14/78 , C12Q1/37 , G01N33/542 , G01N33/577 , G01N33/6893 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is CRP and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
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公开(公告)号：EP2208073A2
公开(公告)日：2010-07-21
申请号：EP08847014.1
申请日：2008-11-04
发明人： KARSDAL, Morten , QVIST, Per , BARASCUK, Natasha
IPC分类号： G01N33/68
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is decorin and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
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公开(公告)号：EP3698142A1
公开(公告)日：2020-08-26
申请号：EP18789143.7
申请日：2018-10-19
IPC分类号： G01N33/68 , C07K16/18 , G01N33/574
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公开(公告)号：EP2208073B1
公开(公告)日：2020-01-15
申请号：EP08847014.1
申请日：2008-11-04
发明人： KARSDAL, Morten , QVIST, Per , BARASCUK, Natasha
IPC分类号： G01N33/68
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公开(公告)号：EP3590959A2
公开(公告)日：2020-01-08
申请号：EP19188754.6
申请日：2012-07-18
发明人： VEIDAL, Sanne , KARSDAL, Morten Asser , LEEMING, Diana Julie , BARASCUK, Natasha , SKJOT-ARKIL, Helene , VASSILIADIS, Efstathios
摘要： Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a bioflui sample, and associating an elevation of said measure in said patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in said sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to said immunological binding partner to measure therein protein fragments comprising said neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described.
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