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    Improved flow cytometer nozzle and flow cytometer sample handling methods
    31.
    发明公开
    Improved flow cytometer nozzle and flow cytometer sample handling methods 有权
    改进的流式细胞仪喷嘴和流式细胞仪样品处理方法

    公开(公告)号：EP2264430A2

    公开(公告)日：2010-12-22

    申请号：EP10182264.1

    申请日：2000-11-29

    申请人： XY, LLC

    发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

    IPC分类号： G01N15/14

    CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

    摘要： A flow cytometer system, comprising a sample injection tube having an injection point through which a sample may be introduced, a sheath fluid container having a bottom end and wherein said sample injection tube is located within said sheath fluid container, a sheath fluid port connected to said sheath fluid container, a first axial motion surface in a nozzle, a second axial motion surface in said nozzle, a limited maximal acceleration differentiation transition area between said first axial motion surface in said nozzle and said second axial motion surface in said nozzle wherein said limited maximal acceleration differentiation transition area is coordinated with said sample so as to be affirmatively limited to not exceed the practical capabilities of said sample over its length and an analytical system which senses below said nozzle.

    摘要翻译： 一种流式细胞仪系统，包括具有注入点的样本注入管，样本可以通过该注入点引入;鞘液流体容器，具有底端，并且其中所述样本注入管位于所述鞘液流体容器内;鞘流体端口，连接到 所述鞘液容器，喷嘴中的第一轴向运动表面，所述喷嘴中的第二轴向运动表面，所述喷嘴中的所述第一轴向运动表面和所述喷嘴中的所述第二轴向运动表面之间的有限的最大加速度区分过渡区，其中所述 有限的最大加速度区分过渡区域与所述样本协调，以便被肯定地限制为不超过所述样本在其长度上的实际能力以及在所述喷嘴下面感测的分析系统。

    Improved flow cytometer nozzle and flow cytometer sample handling methods
    35.
    发明授权
    Improved flow cytometer nozzle and flow cytometer sample handling methods 有权
    改进的流式细胞仪喷嘴和流式细胞仪样品处理方法

    公开(公告)号：EP2264430B1

    公开(公告)日：2018-01-10

    申请号：EP10182264.1

    申请日：2000-11-29

    申请人： XY, LLC

    发明人： Buchanan, Kristopher S. ,  Herickhoff, Lisa

    IPC分类号： G01N15/14 ,  G01N15/00 ,  G01N15/10

    CPC分类号： G01N15/1404 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1409 ,  G01N2015/1413 ,  G01N2015/1415 ,  G01N2015/149 ,  Y10T436/101666

    摘要： An improved nozzle system for a flow cytometer have been invented for a high efficiency orientation and sorting process of a flat sample and dedicates items such as equine or bovine sperm cells. This improved nozzle system comprises a nozzle (16) with a novel interior surface geometry that can both gently accelerate the cells and can include an elliptical-like, single torsional interior surface element within (c) the nozzle, i.e., a single torsional orientation nozzle (6). The elliptical-like, single torsional interior surface element (e.g.) (8, 9, 10) may have a laminar flow surface and may produce the simplest flow path for applying minimal forces which act in either an accelerative nature or orienting hydrodynamic forces, namely, the single torsional orientation forces, to orient a flat sample (16) such as animal sperm cells into a proper direction for an analyzing and efficiently sorting process in clinical use, for research and for the animal insemination industry.

    Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis
    39.
    发明公开
    Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis 失效
    具有用于辐射的收敛聚焦反射器到的粒子流的光学装置，和分析的相关方法

    公开(公告)号：EP2264427A3

    公开(公告)日：2014-05-21

    申请号：EP10182128.8

    申请日：1998-02-02

    申请人： XY, LLC

    发明人： Sharpe, Johnathan ,  Schaare, Peter, Niven

    IPC分类号： G01N15/02 ,  G01N21/00 ,  G02B5/00 ,  G01N15/14 ,  G02B5/04 ,  G01N21/64

    CPC分类号： G01N15/1436 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/49 ,  G01N2015/1452 ,  G01N2015/149 ,  G01N2021/6469 ,  G02B5/04

    摘要： Various optical apparatus provide a source of parallel light (7, 75). The parallel light (7, 75) is generally achieved by directing an incident beam at the apex of a prism (1, 22, 24, 26, 28). The prism may have varying configurations. One configuration has a forward conical face (24). Another configuration has a pyramidal forward end (22). Other configurations arc also disclosed. The application also discloses the use of reflectors (20, 78, 216, 316, 400) having internal reflective surfaces shaped as three-dimensional figures of revolution, for example paraboloid or ellipsoid. The reflectors (20, 78, 216, 316) focus light incident onto the reflectors at one or more foci (F, 220, 320, 420). The reflectors may be used in combination with the optical apparatus including the prisms (1, 22, 24, 26, 28). The reflectors (20, 78, 216, 316) may be used in flow cytometers for focussing light at a sample stream (237, 337) passing through the focus (F, 220, 320, 420) of the reflector (20, 78, 216, 316). The collection of scattered and/or fluorescent light from an illuminated sample stream (237, 337) in a flow cytometer may be achieved with the use of a collector shaped as a figure of revolution e.g. paraboloid or ellipsoid. Various optical methods and methods for flow cytometry are also disclosed.

    Sex-specific insemination of mammals with low number of sperm cells
    40.
    发明公开
    Sex-specific insemination of mammals with low number of sperm cells 审中-公开
    哺乳动物的性别特异性人工授精用少量的精子

    公开(公告)号：EP2329710A3

    公开(公告)日：2013-11-06

    申请号：EP10185733.2

    申请日：1998-12-31

    申请人： XY, LLC

    发明人： Herickhoff, Lisa ,  Seidel, George E. ,  Schenk, John

    IPC分类号： A61D19/02 ,  A01K67/02 ,  C12N5/076 ,  A01K67/027 ,  C12N15/873

    CPC分类号： C12N5/0612 ,  A01K67/027 ,  A61D19/02 ,  C12N15/873 ,  G01N2015/149

    摘要： Artificial Insemination is achieved for sexed mammalian offspring in a commercially practical manner and with dosages of insemination sperm which were not previously thought to be practical for commercial implementation. Improved insemination systems particularly adapted to use for sex-selected sperm sorting include systems which achieve superovulation and then multiple embryo production with sexed embryos. These systems combine with other techniques, including techniques for enhanced sheath fluid (3) and other strategies which minimize stress on the sperm cells (18), and potentially, a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems (14) and techniques for the process are describeb so that commercial application of sperm samples as well as the resulting animals may now be achieved in the field.