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    A SYSTEM AND METHODS FOR THE IN VITRO DETECTION OF PARTICLES AND SOLUBLE CHEMICAL ENTITIES IN BODY FLUIDS
    31.
    发明公开
    A SYSTEM AND METHODS FOR THE IN VITRO DETECTION OF PARTICLES AND SOLUBLE CHEMICAL ENTITIES IN BODY FLUIDS 审中-公开
    SYSTEM UND VERFAHREN ZUM VITRO-NACHWEIS VON PARTIKELN UNDLÖSLICHENCHEMISCHEN STOFFE INKÖRPERFLÜSSIGKEITEN

    公开(公告)号：EP2973408A4

    公开(公告)日：2017-06-14

    申请号：EP14765063

    申请日：2014-03-10

    申请人： TURNER RICHARD HARRY

    发明人： TURNER RICHARD HARRY

    IPC分类号： G06T7/40 ,  B01L3/00 ,  G02B21/08

    CPC分类号： G06T7/0012 ,  B01L3/508 ,  B01L2300/168 ,  G02B21/088 ,  G06T7/33 ,  G06T7/73 ,  G06T2207/10056 ,  G06T2207/10152 ,  G06T2207/30024

    摘要： A system and methods for detecting particles and soluble chemical entities in body fluids consists of a system consisting of a microscopic apparatus, a sample chamber and reagents and methods used to detect, classify and enumerate particles and chemical entities in body fluids. Body fluids containing particles combined with reagents sediment to the bottom of a viewing chamber bringing them into the focal place of a digital microscopic detector. Particles identified as areas within a captured digital image that absorb or emit electromagnetic radiation can be further classified based on additional absorbed or emitted electromagnetic radiation within the predefined areas of the first digital image. Soluble chemical entities in body fluids are detected and concentrations determined using transmitted or emitted electromagnetic radiation using known chemical or antibody reactions, making the microscopic device a general purpose detector for in vitro determinations using body fluids.

    摘要翻译： 用于检测体液中的颗粒和可溶性化学实体的系统和方法由由显微设备，样品室和用于检测，分类和计数体液中的颗粒和化学实体的试剂和方法组成的系统组成。 包含与试剂结合的颗粒的体液沉降到观察室的底部，使其进入数字显微检测器的焦点位置。 可以基于第一数字图像的预定区域内的额外吸收或发射的电磁辐射进一步分类被识别为捕获的数字图像内的吸收或发射电磁辐射的区域的粒子。 检测体液中的可溶化学物质，并使用已知的化学或抗体反应使用透射或发射的电磁辐射测定浓度，使得显微装置成为用于体液测定的通用检测器。

    MICROSCOPE APPARATUS
    34.
    发明公开
    MICROSCOPE APPARATUS 审中-公开
    显微镜设备

    公开(公告)号：EP2887116A1

    公开(公告)日：2015-06-24

    申请号：EP14197505.2

    申请日：2014-12-11

    申请人： Yokogawa Electric Corporation

    发明人： Sangu, Hiroyuki

    IPC分类号： G02B21/00 ,  G02B21/06

    CPC分类号： G02B21/088 ,  G02B21/0032 ,  G02B21/0044 ,  G02B21/0056 ,  G02B21/0076 ,  G02B21/06 ,  G02B21/361

    摘要： A microscope apparatus includes a light source configured to emit a coherent illuminating light, an optical system configured to irradiate a specimen with the illumination light, and a detector configured to form an image based on a light generated from the specimen by the illumination light that irradiates the specimen. The optical system is configured to project a plurality of focal points of the illumination light on the specimen, and allow the plurality of focal points to interfere with each other while changing phases of the plurality of focal points.

    摘要翻译： 本发明提供一种显微镜装置，该显微镜装置具备：射出相干照明光的光源;照射被检体的照明光的光学系统;以及基于照射光的照明光从被检体产生的光形成图像的检测器 标本。 光学系统被配置成将照明光的多个焦点投影到样本上，并且在改变多个焦点的相位的同时允许多个焦点彼此干涉。

    Microscope
    37.
    发明公开
    Microscope 有权
    显微镜

    公开(公告)号：EP2315065A3

    公开(公告)日：2011-07-06

    申请号：EP10013563.1

    申请日：2010-10-12

    申请人： OLYMPUS CORPORATION

    发明人： Honda, Susumu ,  Nakata, Tatsuo

    IPC分类号： G02B21/06 ,  G02B21/08 ,  G02B21/16 ,  G02B21/32

    CPC分类号： G02B21/088 ,  G02B21/06 ,  G02B21/16 ,  G02B21/32

    摘要： Provided is a microscope that allows irradiation with uniform illumination light without decreasing the amount of light. Employed is a microscope 1 including an incoherent light source 31 that emits incoherent light I; an optical fiber 35 on which the incoherent light I is incident and which guides the incident incoherent light I by repeated total reflection; a DMD 37 having an array of movable micromirrors each reflecting or transmitting the guided incoherent light I; an objective lens 18 that irradiates a specimen 19 with the incoherent light I reflected or transmitted by the DMD 37 and that collects fluorescence F coming from the specimen 19; a dichroic mirror 17 that splits off the collected fluorescence F coming from the specimen 19 from the incoherent light I; and a CCD camera 13 that is disposed at a position conjugate to the position of the DMD 37 and that detects the fluorescence F coming from the specimen 19 and split off by the dichroic mirror 17.

    摘要翻译： 提供一种显微镜，其允许以均匀的照明光进行照射而不减少光量。 采用的是包括发射非相干光I的非相干光源31的显微镜1; 一个光纤35，非相干光I入射到该光纤35上，并通过重复的全反射引导入射的非相干光I; DMD 37，其具有各自反射或透射被引导非相干光I的可动微镜阵列; 物镜18，其用由DMD37反射或透射的非相干光I照射样本19并且收集来自样本19的荧光F; 分色镜17，其将来自标本19的收集的荧光F从非相干光I中分离出来; 以及CCD照相机13，其配置在与DMD37的位置共轭的位置，检测来自检体19并被分色镜17分离的荧光F.

    Spatial light modulator apparatus
    38.
    发明公开
    Spatial light modulator apparatus 审中-公开
    RäumlicheLichtmodulatorvorrichtung

    公开(公告)号：EP2293131A1

    公开(公告)日：2011-03-09

    申请号：EP10011528.6

    申请日：2002-07-25

    申请人： Andor Technology PLC

    发明人： DeSimone, Andrew Frank ,  Crary, Bruce

    IPC分类号： G02B21/06 ,  G02B26/00 ,  G09G3/34

    CPC分类号： G02B21/06 ,  G01N21/6458 ,  G02B21/088 ,  G02B21/365 ,  G09G3/346 ,  G09G2300/0857

    摘要： A digital interface interconnected between a controller for a spatial light modulator device and a pattern generation subsystem. The digital interface comprises a clock which provides a clock signal and a logic device responsive to pattern image data output by the pattern generation subsystem and the clock signal and configured to assign pixels to the pattern Image data and to serialize the assigned pixels according to the clock signal to reformat the pattern image data to correspond to the spatial addressing of the spatial light modulator device.

    摘要翻译： 在空间光调制器装置的控制器和图案生成子系统之间互连的数字接口。 数字接口包括响应于由模式生成子系统输出的模式图像数据和时钟信号提供时钟信号和逻辑器件的时钟，并配置为将像素分配给模式图像数据，并根据时钟序列化分配的像素 信号重新格式化图形图像数据以对应于空间光调制器装置的空间寻址。

    Beleuchtungseinrichtung
    39.
    发明公开
    Beleuchtungseinrichtung 审中-公开

    公开(公告)号：EP2239613A1

    公开(公告)日：2010-10-13

    申请号：EP10156826.9

    申请日：2010-03-18

    申请人： Photonic Optische Geräte Ges.m.b.H. & Co.KG

    发明人： Feger, Dieter

    IPC分类号： G02B21/08 ,  G02B21/12

    CPC分类号： G02B21/084 ,  G02B21/088 ,  G02B21/125

    摘要： Eine Beleuchtungseinrichtung (9) für ein mit einem Mikroskop (1) zu untersuchendes Objekt, mit einer Vielzahl von Lichtaustritten (12') eines an eine Lichtquelle angeschlossenen Lichtleiterfaserbündels und/oder von Leuchtdioden (12), welche Lichtaustritte in einem Gehäuse (9a) angeordnet sind, das oberhalb des zu untersuchenden Objekts am Mikroskop (1) zur Dunkelfeldbeleuchtung lösbar befestigbar ist und für den Strahlengang des Objektivs des Mikroskops(1) in seinen Wandungen Öffnungen (10a, 10b) aufweist, wobei die Lichtaustritte (12') geneigt zur optischen Achse des Objektivs angeordnet sind, und eine werkzeuglos vom Gehäuse (9a) entfernbare, das Leuchtfeld der Lichtaustritte (12') abdeckende licht-durchlässige Platte (11) vorgesehen ist, die als Auflagefläche für das zu untersuchende Objekt bei Dunkelfeldbeleuchtung von unten oder bei Hellfeld-Durchlichtbeleuchtung ausgebildet ist.

    摘要翻译： 照明装置（9）具有可拆卸地连接到显微镜（1）并且延伸轴线的壳体（9a）。 壳体设置有用于显微镜物镜的射线路径的开口（10a，10b）。 半透明板以无工具的可释放方式连接到壳体上并从壳体中移除，以覆盖前开口和光出口之一，并且在暗场照明和背光照明场景照明的情况下用作物体的支撑表面 。

    LIGHT PROFILE MICROSCOPY APPARATUS AND METHOD
    40.
    发明公开
    LIGHT PROFILE MICROSCOPY APPARATUS AND METHOD 有权
    光分布曲线显微装置和方法

    公开(公告)号：EP1730570A1

    公开(公告)日：2006-12-13

    申请号：EP05729984.4

    申请日：2005-03-30

    申请人： Power, Joan F.

    发明人： POWER, Joan, F.

    IPC分类号： G02B21/06 ,  G01N21/84

    CPC分类号： G01N21/8422 ,  G02B21/088

    摘要： An apparatus and method allowing an optimized illumination in a light profile microscope by excitation of a sample with an elliptically collimated beam. The beam, which is typically supplied by a laser, is collimated with unequal beam waist radii (and Rayleigh ranges) along major and minor axes orthogonal to a propagation direction, and approximates a plane sheet of illumination. The plane sheet of illumination is aligned with a thinnest width dimension thereof along the optic axis of the microscope objective, and with a center thereof at the object plane of the objective. Excitation light in a test sample is thereby confined to within a narrow thickness of the object plane of the objective lens, which minimizes out-of-focus light in the image. The major axis width of the plane illumination sheet is typically a factor of ten or more greater than the minimum width, allowing a large area of the test sample to be illuminated and imaged. This excitation arrangement optically emulates the operation of micro-toming a thin cross section of a material for analysis, and provides optimum resolution and field in a light profile microscope.