公开(公告)号：EP1687318A4

公开(公告)日：2009-01-07

申请号：EP04817513

申请日：2004-11-01

申请人： UNIV MASSACHUSETTS

发明人： CARPINO LOUIS A ,  XIA JUSONG ,  ZHANG CHONGWU ,  SFERDEAN CALIN DAN

IPC分类号： C07D471/04 ,  C07F9/09 ,  C07F9/6518 ,  C07F9/6521 ,  C07F9/6561 ,  C07F9/6571 ,  C07F9/6574 ,  C07K20060101 ,  C07K1/08 ,  C07K1/10

CPC分类号： C07F9/6561 ,  C07D471/04 ,  C07F9/65188 ,  C07F9/65218 ,  C07F9/657163 ,  C07F9/65742 ,  C07K1/082 ,  C07K1/10

摘要： The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis.

摘要翻译： 本发明涉及式（I）和（II）的化合物或其盐或N-氧化物及其在肽合成中的用途。

公开(公告)号：EP1680443A4

公开(公告)日：2008-09-24

申请号：EP04811198

申请日：2004-11-05

申请人： DANA FARBER CANCER INST INC ,  HARVARD COLLEGE

发明人： WALENSKY LOREN D ,  KORSMEYER STANLEY J ,  VERDINE GREGORY

IPC分类号： C07K14/00 ,  A61K38/00 ,  A61K38/12 ,  C07K20060101 ,  C07K5/12 ,  C07K14/47

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K1/113 ,  C07K1/1136 ,  C07K7/64 ,  C07K14/001 ,  C07K14/435 ,  C07K14/4747

摘要： Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

摘要翻译： 本文描述了新颖的多肽及其制备和使用方法。 多肽包括交联（“烃装订”）部分，以提供限制多肽的二级结构的两个氨基酸部分之间的系链。 本文所述的多肽可用于治疗以过度或不充分的细胞死亡为特征的疾病。

公开(公告)号：EP1745070A4

公开(公告)日：2008-07-23

申请号：EP05739654

申请日：2005-05-09

申请人： BIOHIT OYJ

发明人： SUOVANIEMI OSMO ,  LINNALA AULI

IPC分类号： C07K14/595 ,  C07K20060101 ,  C12N9/96 ,  G01N33/68

CPC分类号： C07K14/595 ,  G01N2333/595

摘要： The present invention is directed to the use of DMSO for the stabilization of temperature sensitive peptides, namely gastrin and gastrin related peptides, against degradation in a mammalian biological sample, such as a serum or plasma sample.

公开(公告)号：EP1575986A4

公开(公告)日：2008-07-16

申请号：EP03724112

申请日：2003-05-08

申请人： UNIV ROCKEFELLER ,  RAPAPORT FAMILY INST FOR RES I

发明人： STELLER HERMANN ,  RYOO HYUNG DON ,  CIECHANOVER AARON ,  GONEN HEDVA

IPC分类号： C07K20060101 ,  C07K1/00 ,  C07K14/47 ,  C07K14/00 ,  C07H21/02 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C07K14/4747 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C12N2799/026

摘要： The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.

公开(公告)号：EP1572080A4

公开(公告)日：2008-06-11

申请号：EP03720833

申请日：2003-05-09

申请人： PROCHON BIOTECH LTD

发明人： BOGIN OREN ,  YAYON AVNER

IPC分类号： A61K38/17 ,  A61K38/18 ,  C07H21/04 ,  C07K20060101 ,  C07K14/50 ,  C07K14/715 ,  A61K38/00

CPC分类号： A61K38/1825 ,  A61K38/22 ,  C07K14/50 ,  C07K14/501 ,  C07K14/503 ,  C07K14/575 ,  C12N5/0655 ,  C12N5/0658 ,  C12N2501/115 ,  C12N2506/1346

摘要： The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided.

摘要翻译： 治疗个体（i）具有异常骨的方法; 或（ii）患有与正常或异常FGF受体或骨骼疾病相关的疾病或病症; 或（iii）具有发育不良的骨。 该方法包括向个体施用包含治疗有效量的包含β8-β9环中至少一个氨基酸取代的成纤维细胞生长因子9（FGF-9）变体的药物组合物，其中所述FGF-9变体包含 SEQ ID NO：11,13,14,15,16或17所示的氨基酸序列之一。

公开(公告)号：EP1678198A4

公开(公告)日：2007-12-05

申请号：EP04809877

申请日：2004-10-07

申请人： PROSPECT PHARMA

发明人： BROWN JONATHAN MILES ,  HOMANS STEVEN W ,  CHAYKOVSKY MICHAEL ,  MURRAY JENNY HONG

IPC分类号： A61K38/00 ,  C07B59/00 ,  C07C229/08 ,  C07K20060101

CPC分类号： C07B59/001 ,  C07B59/008 ,  C07B2200/05

摘要： Protein structural determination using NMR techniques is improved through use of proteins in which one or more amino acids in the peptidic sequence are isotopically enriched in the sidechain with 2H and are isotopically enriched on the backbone with 13C, 15N, 2H or any combination thereof. This invention provides amino acids isotopically enriched as above, which can be used to synthesize isotopically labeled proteins and peptides for protein structural determinations by NMR, and methods for their synthesis. Other embodiments of the invention include peptidic molecules, media for peptidic molecule expression, methods of making isotopically labeled peptidic molecules and methods of determining structural information of a peptidic molecule.

公开(公告)号：EP1648919A4

公开(公告)日：2007-08-01

申请号：EP04779108

申请日：2004-07-22

申请人： BECKMAN COULTER INC

发明人： CHANG JENNIE CHYAN CHUU ,  KASEY SUHA ,  CREBASSA VERONIQUE TRIGUEROS ,  MONTERO-JULIAN FELIX A

IPC分类号： G01N33/543 ,  C07K20060101 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

CPC分类号： G01N33/505 ,  G01N33/56977

摘要： The present invention is based on the discovery that MHC monomers immobilized to a solid surface are capable of activating T-cells that recognize specific peptides in the context of MHC Class I or Class II molecules. Methods for detecting T-cells responding to MHC monomers, and methods for measuring the frequency of specific and activated T-cells in a heterogeneous population are provided. The present invention also provides systems and kits useful for conducting the methods of the present invention.

公开(公告)号：EP1575989A4

公开(公告)日：2007-05-16

申请号：EP03754894

申请日：2003-09-26

申请人： CAPRION PHARMACEUTICALS INC

发明人： CASHMAN NEIL ,  PARAMITHIOTIS EUSTACHE ,  LA BOISSIERE SYLVIE ,  LAWTON ROBERT ,  FRANCOEUR GREG ,  ESTEY LISA ,  PINARD MARC

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  C07K20060101 ,  C07K1/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68

CPC分类号： G01N33/6896 ,  G01N2469/20 ,  G01N2500/00 ,  G01N2800/2828

公开(公告)号：EP1409547A4

公开(公告)日：2007-05-02

申请号：EP02733206

申请日：2002-06-18

申请人： TECHNION RES AND DEV OF FOUNDA ,  TEVA PHARMA

发明人： REITER YORAM ,  LEV AVITAL

IPC分类号： C12N15/09 ,  A61K39/00 ,  A61P35/00 ,  C07K20060101 ,  C07K14/47 ,  C07K14/74 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/00 ,  C07K16/00 ,  C07K5/00 ,  C07K14/00

CPC分类号： C07K14/70539 ,  A61K2039/505 ,  C07K16/2866 ,  C07K16/30 ,  C07K2317/624 ,  C07K2319/00

公开(公告)号：EP1476185A4

公开(公告)日：2007-04-04

申请号：EP02802898

申请日：2002-11-08

申请人： PFIZER PROD INC ,  ABGENIX INC

发明人： BEDIAN VAHE ,  GLADUE RONALD P ,  CORVALAN JOSE ,  JIA XIAO-CHI ,  FENG XIAO

IPC分类号： A01H5/00 ,  A01K67/027 ,  A61K31/7088 ,  A61K35/76 ,  A61K39/395 ,  A61K48/00 ,  A61P13/08 ,  A61P13/10 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07K20060101 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12N15/00 ,  C12N15/11 ,  C12N15/63

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  A61N5/062 ,  A61N5/10 ,  C07K16/2878 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.