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公开(公告)号：EP3426372A1
公开(公告)日：2019-01-16
申请号：EP17717049.5
申请日：2017-03-30
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公开(公告)号：EP3319739A1
公开(公告)日：2018-05-16
申请号：EP16753490.8
申请日：2016-07-09
发明人： LIPKENS, Bart , PRESZ, Walter, M., Jr. , CHITALE, Kedar , KENNEDY, Thomas, J., III , GILMANSHIN, Rudolf , MEALEY, Dane , DUTRA, Brian , SOKOLOWSKI, David
CPC分类号： B06B1/0238 , B01D21/0009 , B01D21/283 , B06B1/0644 , B06B3/04 , C12M47/02 , H03H9/17
摘要： An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
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公开(公告)号：EP2838582B1
公开(公告)日：2018-01-10
申请号：EP13721179.3
申请日：2013-04-19
发明人： DUTRA, Brian , LIPKENS, Bart
IPC分类号： A61M1/38
CPC分类号： A61M1/3681 , A61M1/363 , A61M1/3678 , A61M2202/08 , B01D21/283
摘要： A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.
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公开(公告)号：EP3092049A1
公开(公告)日：2016-11-16
申请号：EP15700941.6
申请日：2015-01-08
发明人： LIPKENS, Bart , MCCARTHY, Brian , ROSS-JOHNSRUD, Ben , BARNES, Jason , MEALEY, Dane , KENNEDY, III, Thomas J.
IPC分类号： B01D21/28
CPC分类号： C12N13/00 , B01D21/283
摘要： An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
摘要翻译： 一种声电泳装置包括具有位于其体积内的压电元件（160）的声室（155,157）。 压电元件振动并从两侧产生声驻波，使得颗粒可以与通过声室的流体分离。 这允许元件更有效地冷却，减少流过装置的流体中的瞬时热负荷。
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公开(公告)号：EP3019606A1
公开(公告)日：2016-05-18
申请号：EP14823682.1
申请日：2014-07-11
CPC分类号： C12N13/00 , B06B1/0238 , B06B1/0648 , B06B2201/76 , C07K1/145 , C12M47/02 , C12P21/02
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
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公开(公告)号：EP2953700A1
公开(公告)日：2015-12-16
申请号：EP14749278.9
申请日：2014-02-07
发明人： LIPKENS, Bart , MASI, Louis , KOWALSKI III, Stanley , PRESZ, Walter M. jr. , DIONNE, Jason , DUTRA, Brian , MERCADO, Ari , KENNEDY III, Thomas , MARTIN, Arthur
IPC分类号： B01D21/28
CPC分类号： C12M47/06 , B01D21/283 , C12M29/10 , C12M33/08 , C12M47/02
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor. The bioreactor includes a reaction vessel, an agitator, a feed inlet, and an outlet. A filtering device is included that has an inlet, a flow chamber and a sleeve surrounding the flow chamber, where the sleeve includes the ultrasonic transducer.
摘要翻译： 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中，并且还可用于从生物反应器中生产的废物中脱水或进一步收获产品。 生物反应器包括反应容器，搅拌器，进料口和出口。 包括过滤装置，其具有入口，流动室和围绕流动室的套筒，其中套筒包括超声换能器。
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47.发明公开ACOUSTOPHORETIC SEPARATION TECHNOLOGY USING MULTI-DIMENSIONAL STANDING WAVES 审中-公开对于多维AKUSTOPHORETISCHE驻波分离技术
公开(公告)号：EP2903715A2
公开(公告)日：2015-08-12
申请号：EP13844181.1
申请日：2013-09-13
CPC分类号： B06B1/06 , B06B2201/70 , C12M47/02
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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公开(公告)号：EP2748301A4
公开(公告)日：2015-08-05
申请号：EP12826150
申请日：2012-08-22
申请人： FLODESIGN SONICS INC
发明人： DIONNE JASON , KING JEFF , LIPKENS BART , RIETMAN EDWARD A
CPC分类号： B06B1/0625 , C12M33/00 , C12M33/12 , C12M33/22 , C12M47/02
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49.发明公开IMPROVED SEPARATION OF MULTI-COMPONENT FLUID THROUGH ULTRASONIC ACOUSTOPHORESIS 审中-公开BY超声acoustophoresis多份流体改善分离
公开(公告)号：EP2872234A1
公开(公告)日：2015-05-20
申请号：EP13742354.7
申请日：2013-07-16
发明人： LIPKENS, Bart , DIONNE, Jason , MERCADO, Ari , DUTRA, Brian , PRESZ, Walter, Jr. , MASI, Louis , KENNEDY, Thomas J., III
CPC分类号： B01D17/045 , B06B1/0644 , C02F1/36 , C02F1/40 , C12M47/02
摘要： An acoustic standing wave is utilized to separate components from a multi- component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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50.发明公开ULTRASOUND AND ACOUSTOPHORESIS TECHNOLOGY FOR SEPARATION OF OIL AND WATER, WITH APPLICATION TO PRODUCE WATER 审中-公开超声和AKUSTOPHORESETECHNOLOGIE对水生产中的应用油水分离
公开(公告)号：EP2558179A2
公开(公告)日：2013-02-20
申请号：EP11769474.5
申请日：2011-04-12
摘要： Several prototype systems are described for separating oil and water from emulsions. The systems operate at ultrasonic resonance and are thus low power. Each system contains one or more acoustic transducers operating in the 100 kHz to 5 MHz range. Each system contains flow input for the emulsion and two or more flow outputs for the separated oil and water. Existing prototypes operate from 200 mL/min to >15 L/min. Each uses low power in the range of 1-5 W.
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