摘要:
L'invention concerne des formes solubles et liées à une membrane de FcgammaRIII humain, ainsi que des acides nucléiques capables de les coder. Les FcgammaRIII sensibles sont utiles pour améliorer la carence de plaquettes de sérum associée au purpura thrombocytopénique immun. Les cellules exprimant le FcgammaRIII lié à une membrane sont des composants utiles dans des analyses visant à détecter des complexes immuns de sérum.
摘要:
Soluble and membrane-bound forms of human FcγRIII are provided, together with nucleic acids capable of encoding the same. Soluble FcγRIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound FcγRIII are useful components in assays for serum immune complexes.
摘要:
Des anticorps monoclonaux ainsi que des compositions les contenant, décrits dans la présente invention, permettent de détecter, mesurer et immunopurifier le facteur de stimulation de colonies de granulocytes-macrophages (GM-CSF) humains.
摘要:
Mutant murine interleukin-2 proteins (muteins) are provided. Muteins containing deletions and/or substitutions within the first 30 N-terminal amino acids are almost all biologically active. The frequence of biologically active mutants is much lower for deletions and/or substitutions in other regions of the native protein.
摘要:
Soluble and membrane-bound forms of human FcγRIII are provided, together with nucleic acids capable of encoding the same. Soluble FcγRIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound FcγRIII are useful components in assays for serum immune complexes.
摘要:
A method of reducing immunoglobulin E responses associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-4. Preferably the antagonist is a blocking monoclonal antibody specific for human interleukin-4, or a fragment or binding composition derived therefrom.
摘要:
Monoclonal antibodies are provided which are specific for human interleukin-4. Kits and methods are also provided for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
摘要:
cDNA clones are provided which allow the production of polypeptides exhibiting glycosylation inhibiting factor (GIF) activity. Such polypeptides are useful in the treatment of atopic disease. A clone, designated TGIF4, which is capable of encoding mouse polypeptides having GIF activity, is deposited with the ATCC under accession number 67311.
摘要:
Immunosuppressive peptides having glycosylation inhibiting factor activity are provided. The peptides include the following sequence and its homologs:
H - Cys - Val - Cys - Val - Cys - Leu - Leu - Pro - Arg - Tyr - Pro - Ser - Ala - Gly - Val - Phe - Thr - Tyr - Leu - Asn - Thr - Lys - Ile - Ile - Thr - Phe - Asp - Ser - Val - Leu - Ser - Lys - Cys - Ala - OH.