Murine-interleukin-2 muteins
    44.
    发明公开
    Murine-interleukin-2 muteins 失效
    鼠白细胞介素-2突变蛋白

    公开(公告)号:EP0267795A3

    公开(公告)日:1990-07-25

    申请号:EP87310005.1

    申请日:1987-11-12

    IPC分类号: C07K13/00

    CPC分类号: C12N15/70 C07K14/55

    摘要: Mutant murine interleukin-2 proteins (muteins) are provided. Muteins containing deletions and/or substitutions within the first 30 N-terminal amino acids are almost all biologically active. The frequence of biologically active mutants is much lower for deletions and/or substitutions in other regions of the native protein.

    摘要翻译: 提供了突变的鼠白细胞介素-2蛋白(突变蛋白)。 在前30个N-末端氨基酸内含有缺失和/或取代的突变蛋白几乎全部具有生物活性。 对于天然蛋白质的其他区域中的缺失和/或取代,生物活性突变体的频率要低得多。

    Human receptor Fc(gamma)RIII
    46.
    发明公开
    Human receptor Fc(gamma)RIII 失效
    人类Fc-γ受体3。

    公开(公告)号:EP0343950A2

    公开(公告)日:1989-11-29

    申请号:EP89305241.5

    申请日:1989-05-24

    IPC分类号: C07K14/00 C12N15/13 G01N33/53

    摘要: Soluble and membrane-bound forms of human FcγRIII are provided, together with nucleic acids capable of encoding the same. Soluble FcγRIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound FcγRIII are useful components in assays for serum immune complexes.

    摘要翻译: 提供人FcγRIII的可溶性和膜结合形式以及能够编码它们的核酸。 可溶性FcγRIII可用于改善与免疫性血小板减少性紫癜相关的血小板缺陷。 表达膜结合的FcγRIII的细胞是血清免疫复合物测定中的有用成分。

    Method of reducing immunoglobulin E responses
    47.
    发明公开
    Method of reducing immunoglobulin E responses 无效
    Methode zur Verminderung der Immunglobulin-E-Reaktion。

    公开(公告)号:EP0327283A1

    公开(公告)日:1989-08-09

    申请号:EP89300872.2

    申请日:1989-01-30

    IPC分类号: A61K39/395 C12P21/00

    CPC分类号: C07K16/247 A61K38/00

    摘要: A method of reducing immunoglobulin E responses associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-4. Preferably the antagonist is a blocking monoclonal antibody specific for human interleukin-4, or a fragment or binding composition derived therefrom.

    摘要翻译: 提供了减少与某些免疫疾病相关的免疫球蛋白E反应的方法。 该方法包括向人白介素-4施用有效量的拮抗剂。 优选地,拮抗剂是对人白细胞介素-4特异性的阻断单克隆抗体或由其衍生的片段或结合组合物。

    Glycosylation inhibition factors
    49.
    发明公开
    Glycosylation inhibition factors 失效
    糖果冰淇淋

    公开(公告)号:EP0285405A1

    公开(公告)日:1988-10-05

    申请号:EP88302862.3

    申请日:1988-03-30

    IPC分类号: C12N15/00 C12P21/02 C07K13/00

    CPC分类号: C07K14/52 A61K38/00

    摘要: cDNA clones are provided which allow the production of polypeptides exhibiting glycosylation inhibiting factor (GIF) activity. Such polypeptides are useful in the treatment of atopic disease. A clone, designated TGIF4, which is capable of encoding mouse polypeptides having GIF activity, is deposited with the ATCC under accession number 67311.

    摘要翻译: 提供cDNA克隆,其允许产生显示糖基化抑制因子(GIF)活性的多肽。 这样的多肽可用于治疗特应性疾病。 能够编码具有GIF活性的小鼠多肽的指定为TGIF4的克隆,保藏于ATCC,登录号为67311。

    Immunosuppressive peptides
    50.
    发明公开
    Immunosuppressive peptides 失效
    免疫抑制肽。

    公开(公告)号:EP0255394A2

    公开(公告)日:1988-02-03

    申请号:EP87306787.0

    申请日:1987-07-31

    IPC分类号: C07K7/10 A61K37/02

    CPC分类号: C07K14/52 A61K38/00

    摘要: Immunosuppressive peptides having glycosylation inhibiting factor activity are provided. The peptides include the following sequence and its homologs:

    H - Cys - Val - Cys - Val - Cys - Leu - Leu - ­Pro - Arg - Tyr - Pro - Ser - Ala - Gly - ­Val - Phe - Thr - Tyr - Leu - Asn - Thr - ­Lys - Ile - Ile - Thr - Phe - Asp - Ser - ­Val - Leu - Ser - Lys - Cys - Ala - OH.

    摘要翻译: 提供具有糖基化抑制因子活性的免疫抑制肽。 肽包括以下序列及其同源物:H-Cys-Val-Cys-Val-Cys-Leu-Leu-Pro-Arg-Tyr-Pro-Ser-Ala-Gly-Val-Phe-Thr-Tyr-Leu- Asn-Thr-Lys-Ile-Ile-Thr-Phe-Asp-Ser-Val-Leu-Ser-Lys-Cys-Ala-OH。