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公开(公告)号：EP0319307A3
公开(公告)日：1989-08-30
申请号：EP88311408.4
申请日：1988-12-01
发明人： Moore, Kevin W. , Peltz, Gary A.
IPC分类号： C12N15/00 , A61K37/02 , G01N33/566
CPC分类号： G01N33/564 , C07K14/70535
摘要： A cDNA clone is provided which encodes a human receptor for the Fc portion of immunoglobulin G. Soluble forms of the receptor may be useful in treating disorders associated with excessive immunoglobulin G production. Cells expressing membrane-bound forms of the receptor are useful in assays for immune complexes, elevated levels of which are associated with numerous disease states, including systemic lupus erythematosus (SLE) and rheumatoid arthritis.
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公开(公告)号：EP0791653A1
公开(公告)日：1997-08-27
申请号：EP97106398.7
申请日：1989-05-24
发明人： Peltz, Gary A. , Moore, Kevin W.
IPC分类号： C12N15/12 , C07K14/735 , A61K38/17
CPC分类号： G01N33/566 , A61K38/00 , C07K14/70535 , C12N13/00 , G01N33/564
摘要： Soluble and membrane-bound human FcγRIII and variants are provided, together with nucleic acids encoding the same. Also described are pharmaceutical compositions containing FcγRIII or variants and the use of these proteins for treatment of immune thrombocytopenic purpura.
摘要翻译： 提供可溶性和膜结合的人FcγRIII和变体以及编码其的核酸。 还描述了含有FcγRIII或变体的药物组合物以及这些蛋白质用于治疗免疫性血小板减少性紫癜的用途。
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公开(公告)号：EP0319307A2
公开(公告)日：1989-06-07
申请号：EP88311408.4
申请日：1988-12-01
发明人： Moore, Kevin W. , Peltz, Gary A.
IPC分类号： C12N15/00 , A61K37/02 , G01N33/566
CPC分类号： G01N33/564 , C07K14/70535
摘要： A cDNA clone is provided which encodes a human receptor for the Fc portion of immunoglobulin G. Soluble forms of the receptor may be useful in treating disorders associated with excessive immunoglobulin G production. Cells expressing membrane-bound forms of the receptor are useful in assays for immune complexes, elevated levels of which are associated with numerous disease states, including systemic lupus erythematosus (SLE) and rheumatoid arthritis.
摘要翻译： 提供cDNA克隆，其编码免疫球蛋白G的Fc部分的人受体。受体的可溶形式可用于治疗与过量免疫球蛋白G产生相关的疾病。 表达受体的膜结合形式的细胞可用于免疫复合物的检测，其升高水平与多种疾病状态相关，包括系统性红斑狼疮（SLE）和类风湿性关节炎。
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公开(公告)号：EP0343950A3
公开(公告)日：1991-07-10
申请号：EP89305241.5
申请日：1989-05-24
发明人： Peltz, Gary A. , Moore, Kevin W.
CPC分类号： G01N33/566 , A61K38/00 , C07K14/70535 , C12N13/00 , G01N33/564
摘要： Soluble and membrane-bound forms of human FcγRIII are provided, together with nucleic acids capable of encoding the same. Soluble FcγRIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound FcγRIII are useful components in assays for serum immune complexes.
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公开(公告)号：EP0343950A2
公开(公告)日：1989-11-29
申请号：EP89305241.5
申请日：1989-05-24
发明人： Peltz, Gary A. , Moore, Kevin W.
CPC分类号： G01N33/566 , A61K38/00 , C07K14/70535 , C12N13/00 , G01N33/564
摘要： Soluble and membrane-bound forms of human FcγRIII are provided, together with nucleic acids capable of encoding the same. Soluble FcγRIIIs are useful in ameliorating the serum platelet deficiency associated with immune thrombocytopenic purpura. Cells expressing membrane-bound FcγRIII are useful components in assays for serum immune complexes.
摘要翻译： 提供人FcγRIII的可溶性和膜结合形式以及能够编码它们的核酸。 可溶性FcγRIII可用于改善与免疫性血小板减少性紫癜相关的血小板缺陷。 表达膜结合的FcγRIII的细胞是血清免疫复合物测定中的有用成分。
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公开(公告)号：EP0285405A1
公开(公告)日：1988-10-05
申请号：EP88302862.3
申请日：1988-03-30
摘要： cDNA clones are provided which allow the production of polypeptides exhibiting glycosylation inhibiting factor (GIF) activity. Such polypeptides are useful in the treatment of atopic disease. A clone, designated TGIF4, which is capable of encoding mouse polypeptides having GIF activity, is deposited with the ATCC under accession number 67311.
摘要翻译： 提供cDNA克隆，其允许产生显示糖基化抑制因子（GIF）活性的多肽。 这样的多肽可用于治疗特应性疾病。 能够编码具有GIF活性的小鼠多肽的指定为TGIF4的克隆，保藏于ATCC，登录号为67311。
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7.发明公开cDNA clones coding for polypeptides exhibiting IgE binding factor activity 失效CDNS克隆编码包含多肽的IgE结合因子活性。
公开(公告)号：EP0155192A2
公开(公告)日：1985-09-18
申请号：EP85301834.9
申请日：1985-03-15
CPC分类号： C07K14/47 , A61K38/00 , Y10S930/26
摘要： Plasmid vectors are provided that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting mammalian IgE binding factor activity. One of these clones contains an open reading frame consisting of 556 codons. The cDNA is derived for example from messenger RNA isolated from a rat/mouse T-cell hybridoma line. The cDNA can be cloned by incorporation into a pcD plasmid vector. The plasmid vector also contains DNA segments from th SV40 virus, permitting expression of the cDNA to form a polypeptide having IgE potentiating activity after transfection into a mammalian host cell, such as monkey Cos7 cells.
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