公开(公告)号：EP2228444A1

公开(公告)日：2010-09-15

申请号：EP09154684.6

申请日：2009-03-09

申请人： Julius-Maximilians-Universität Würzburg

发明人： Engelhardt, Stefan ,  Jentzsch, Claudia

IPC分类号： C12N15/11

CPC分类号： C12N15/113 ,  C12N2310/141

摘要： The present invention relates to the use of microRNA and an antisense oligonucleotide for the manufacture of a medicament for the treatment and/or prevention and for the diagnosis of various diseases. An implant is also encompassed by the invention. The invention is directed to the use of microRNA for the manufacture of an implant. The present invention further relates to the use of microRNA or an antisense oligonucleotide against the microRNA for inducing a modification of a morphological phenotype of a cell. Additionally, the invention concerns a method for diagnosing a cardiovascular disease and a method for screening a pharmaceutically active compound for the treatment and/or prevention of a cardiovascular disease or a predisposition thereof.

摘要翻译： 本发明涉及微RNA和反义寡核苷酸在制备用于治疗和/或预防和诊断各种疾病的药物中的用途。 植入物也包括在本发明中。 本发明涉及使用微小RNA来制造植入物。 本发明还涉及微小RNA或针对微小RNA的反义寡核苷酸用于诱导细胞形态表型修饰的用途。 此外，本发明涉及用于诊断心血管疾病的方法和用于筛选用于治疗和/或预防心血管疾病或其倾向的药学活性化合物的方法。

公开(公告)号：EP2190466A2

公开(公告)日：2010-06-02

申请号：EP08833850.4

申请日：2008-08-09

申请人： Burnham Institute for Medical Research

发明人： MILLAN, Jose, Luis ,  SERGIENKO, Eduard

IPC分类号： A61K38/46 ,  C12N9/14

CPC分类号： A61K31/519 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5395 ,  A61K38/00 ,  C12N9/16 ,  C12Y301/03001

摘要： Disclosed herein are tissue-nonspecific alkaline phosphatase (TNAP) activators and uses thereof for promoting bone mineral deposition.

公开(公告)号：EP2153845A1

公开(公告)日：2010-02-17

申请号：EP08014455.3

申请日：2008-08-13

申请人： Julius-Maximilians-Universität Würzburg

发明人： Becker, Jürgen ,  Hofmeister, Valeska ,  Schrama, David

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K2039/53 ,  C07K14/70596

摘要： The present invention concerns artificial peptides derived from endoglin (CD105) for the treatment of cancer. Furthermore, the invention relates to polypeptides comprising the artificial peptide, nucleic acids encoding the artificial peptide or polypeptide, antibodies against the artificial peptide and vaccines comprising at least one substance selected from the group consisting of a peptide, a nucleic acid and an antibody for the treatment of cancer. The present invention also concerns a method for preparing a vaccine and the use of a peptide, polypeptide, nucleic acid or antibody for the manufacture of a drug and/or a vaccine for the treatment and/or prevention of cancer or an immunological disorder.

摘要翻译： 本发明涉及用于治疗癌症的源自内皮因子（CD105）的人工肽。 此外，本发明涉及包含人造肽的多肽，编码人工肽或多肽的核酸，针对人造肽的抗体和包含至少一种选自肽，核酸和抗体的物质的疫苗 治疗癌症。 本发明还涉及制备疫苗的方法以及肽，多肽，核酸或抗体在制备用于治疗和/或预防癌症或免疫学病症的药物和/或疫苗中的用途。

公开(公告)号：EP2153188A1

公开(公告)日：2010-02-17

申请号：EP08758830.7

申请日：2008-05-28

申请人： Pyreos Ltd.

发明人： GIEBELER, Carsten ,  SCHREITER, Matthias ,  ZAPF, Jörg

IPC分类号： G01J5/34 ,  G01J5/10 ,  H01L27/16 ,  H01L31/0203

CPC分类号： H01L27/16 ,  G01J5/04 ,  G01J5/045 ,  G01J5/10 ,  G01J5/34 ,  H01L27/14618 ,  H01L2924/0002 ,  H01L2924/00

摘要： The invention relates to a device (1) for detecting thermal radiation, comprising at least one stack (10) having at least one detector carrier (11) with at least one thermal detector element (111) for converting the thermal radiation to an electrical signal, at least one circuit carrier (12) having at least one readout circuit (121, 122) for reading out the electrical signal, and at least one cover (13) for covering the detector element. The detector carrier and the cover are arranged on each other in such a manner that at least one first stack cavity (14) of the stack is produced between the detector element of the detector carrier and the cover, said cavity being delimited by the detector carrier and the cover. The circuit carrier and the detector carrier are arranged on each other in such a manner that at least one second stack cavity (15) of the stack is produced between the detector carrier and the circuit carrier, said cavity being delimited by the circuit carrier and the detector carrier. The first stack cavity and/or the second stack cavity are or can be evacuated. The invention also relates to a method for producing said device. The detector carrier, circuit carrier and the cover are preferably produced from silicon. The production is preferably carried out on the wafer level: Functionalized silicon substrates are stacked, firmly interconnected and then subdivided. The detector elements are preferably pyroelectric detector elements. The device according to the invention is used in motion detectors, presence detectors and thermal imaging cameras.

公开(公告)号：EP2153187A1

公开(公告)日：2010-02-17

申请号：EP08758829.9

申请日：2008-05-28

申请人： Pyreos Ltd.

发明人： GIEBELER, Carsten ,  SCHREITER, Matthias ,  PAULUS, Christian

IPC分类号： G01J5/04 ,  G01J5/10 ,  G01J5/22

CPC分类号： G01J5/34 ,  G01J5/00 ,  G01J5/0205 ,  G01J5/0225 ,  G01J5/023 ,  G01J5/04 ,  G01J5/041 ,  G01J5/045 ,  G01J5/14 ,  G01J5/22 ,  G01J2005/0077 ,  G01J2005/204 ,  G01N2021/0106 ,  H01L27/14683 ,  H01L41/0973 ,  Y10T156/10

摘要： The invention relates to a device for detecting thermal radiation, comprising at least one membrane on which at least one thermal detector element for converting the thermal radiation to an electrical signal is arranged, and at least one circuit carrier for carrying the membrane and for carrying at least one readout circuit for reading out the electrical signal, the detector element and the readout circuit being electrically interconnected through the membrane through an electrical via. The invention also relates to a method for producing said device by way of the following process steps: a) providing the membrane having the detector element and at least one electrical via and providing the circuit carrier, and b) uniting the membrane and the circuit carrier in such a manner that the detector element and the readout circuit are electrically interconnected through the membrane through an electrical via. The production is preferably carried out on the wafer level: Functionalized silicon substrates are stacked, firmly interconnected and then subdivided. The detector elements are preferably pyroelectric detector elements. The device according to the invention is used in motion detectors, presence detectors and thermal imaging cameras.

公开(公告)号：EP2129776A1

公开(公告)日：2009-12-09

申请号：EP08731065.2

申请日：2008-02-29

申请人： THE CATHOLIC UNIVERSITY OF AMERICA

发明人： ALVING, Carl R. ,  RAO, Venigalla

IPC分类号： C12N7/00 ,  C12N15/63 ,  A61K35/00 ,  A61K48/00 ,  C12P21/00

CPC分类号： A61K39/39 ,  A61K39/12 ,  A61K39/21 ,  A61K39/385 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/735 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2795/10122

摘要： T4 bacteriophages are bound to substrates such as liposomes using a binder.

摘要翻译： 配体 - 受体粘合剂体系也可以用作T4-脂质体粘合剂。

公开(公告)号：EP2117575A2

公开(公告)日：2009-11-18

申请号：EP07870130.7

申请日：2007-12-31

申请人： Burnham Institute for Medical Research

发明人： RUOSLAHTI, Erkki ,  SIMBERG, Dimitri

IPC分类号： A61K38/04 ,  A61K39/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/04

CPC分类号： A61K47/48861 ,  A61K47/48238 ,  A61K47/48815 ,  A61K47/48884 ,  A61K47/62 ,  A61K47/6911 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1863 ,  A61K49/1866 ,  B82Y5/00 ,  Y10T428/2984

摘要： Disclosed are compositions and methods related to clot binding compounds. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.

公开(公告)号：EP2108024A1

公开(公告)日：2009-10-14

申请号：EP08706304.6

申请日：2008-01-24

申请人： Kelsan Technologies Corp.

发明人： COTTER, John ,  MORGAN, Annette ,  LU, Xin ,  EADIE, Donald

IPC分类号： C08L63/10 ,  B05D5/08 ,  B61C17/08 ,  C08J5/16 ,  C08K3/30 ,  C08L63/02

CPC分类号： B61K3/00 ,  C08L63/00 ,  C10M169/04 ,  C10M2201/041 ,  C10M2201/0413 ,  C10M2201/061 ,  C10M2201/0613 ,  C10M2201/065 ,  C10M2201/0653 ,  C10M2201/066 ,  C10M2201/0663 ,  C10M2201/087 ,  C10M2201/0873 ,  C10M2205/04 ,  C10M2207/1253 ,  C10M2207/127 ,  C10M2209/062 ,  C10M2209/0625 ,  C10M2209/102 ,  C10M2209/1023 ,  C10M2209/103 ,  C10M2209/1033 ,  C10M2215/06 ,  C10N2210/08 ,  C10N2230/06 ,  C10N2210/06 ,  C10N2210/03 ,  C10N2260/08

摘要： A solid stick composition for use on steel surfaces that are in sliding or rolling-sliding contact. The solid stick composition comprises a vinyl ester resin, for example, from about 20 to about 80 weight percent vinyl ester resin, a solid lubricant, for example from about 0 to about 80 weight percent lubricant, and optionally a friction modifier, for example from about 0 to about 40% weight percent friction modifier, or a combination of a solid lubricant and a friction modifier. The solid stick comprises at least one of the lubricant or the friction modifier. A method of controlling friction between a metal surface and a second metal surface by applying the solid stick composition to one or more than one of the metal surfaces is also disclosed as well as a method of reducing lateral force in a rail system comprising applying the solid stick composition onto a wheel or rail surface.

公开(公告)号：EP2094869A2

公开(公告)日：2009-09-02

申请号：EP07818845.5

申请日：2007-10-09

申请人： Julius-Maximilians-Universität Würzburg

发明人： THUM, Thomas ,  BAUERSACHS, Johann

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2330/10 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q1/6809 ,  C12Q2600/118

摘要： The invention relates to microRNAs (miRNAs) for the diagnosis, prophylaxis and/or treatment of heart diseases, and especially to SEQ ID NR: 1 bis SEQ ID NR: 29 for the diagnosis, prophylaxis and/or treatment of heart diseases. The invention also relates to the use of said sequences for producing a medicament for heart diseases and for the diagnosis of heart diseases. The invention further relates to a method for diagnosing a heart disease, a kit and an expression vector comprising said sequences, a cell containing the expression vector, a method for modulating a heart disease, and a method for screening a pharmaceutically active compound for the treatment and/or prophylaxis of a heart disease.

公开(公告)号：EP2094356A2

公开(公告)日：2009-09-02

申请号：EP06838452.8

申请日：2006-11-28

申请人： THE CATHOLIC UNIVERSITY OF AMERICA

发明人： LITOVITZ, Théodore

IPC分类号： A61N2/00

CPC分类号： A61N2/02

摘要： The present invention provides a method and apparatus for delivering an electric field to a body, comprising delivering a polarized magnetic field in a first direction to a body and directed at a desired target within the body, and changing the delivery direction of the magnetic field to a second direction directed at the desired target to induce an electric field across the desired target.