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公开(公告)号：EP3417912B1
公开(公告)日：2020-08-12
申请号：EP18183366.6
申请日：2006-12-22
发明人： ZOU, Dong , METCALF, Chester A, III , DALGARNO, David C , SAWYER, Tomi K , HUANG, Wei-sheng , THOMAS, Mathew R , ROMERO, Jan Antoinette C , QI, Jiwei , WANG, Yihan , ZHU, Xiaotian , SHAKESPEARE, William C , SUNDARAMOORTHI, Rajeswari
IPC分类号： A61P35/00 , A61K31/4745 , A61K31/519 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/5025 , C07D471/02 , C07D487/04 , C07D471/04 , C07D473/34
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公开(公告)号：EP3209647B1
公开(公告)日：2020-06-03
申请号：EP15787846.3
申请日：2015-10-21
IPC分类号： C07D239/48 , A61K31/506 , A61P35/00
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公开(公告)号：EP3409669A1
公开(公告)日：2018-12-05
申请号：EP18182201.6
申请日：2015-05-13
发明人： HUANG, Wei-sheng , GONG, Yongjin , LI, Feng , BENCIVENGA, Nicholas, E. , DALGARNO, David, C. , KOHLMANN, Anna , SHAKESPEARE, William, C. , THOMAS, Ranny, M. , ZHU, Xiaotian , WEST, Angela, V. , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D405/12 , C07D471/04 , C07D401/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
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公开(公告)号：EP2300013B1
公开(公告)日：2017-09-06
申请号：EP09751617.3
申请日：2009-05-21
发明人： WANG, Yihan , HUANG, Wei-Sheng , LIU, Shuangying , SHAKESPEARE, William, C. , THOMAS, R., Mathew , QI, Jiwei , LI, Feng , ZHU, Xiaotian , KOHLMANN, Anna , DALGARNO, David, C. , ROMERO, Jan, Antoinette, C. , ZOU, Dong
IPC分类号： A61K31/505 , A61K31/513
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/587 , C07F9/650941 , C07F9/65122 , C07F9/65127 , C07F9/65216 , C07F9/65217 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
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公开(公告)号：EP3143015A1
公开(公告)日：2017-03-22
申请号：EP15792086.9
申请日：2015-05-13
发明人： HUANG, Wei-Sheng , LI, Feng , DALGARNO, David, C. , GONG, Yongjin , ISHCHENKO, Alexey, V. , KOHLMANN, Anna , SHAKESPEARE, William, C. , WEST, Angela, V. , XU, Yongjin , YOUNGSAYE, Willmen , ZHANG, Yun , ZHOU, Tianjun , ZHU, Xiaotian
IPC分类号： C07D403/14 , C07D473/16
CPC分类号： C07F9/6561 , C07D471/06 , C07D487/06 , C07D498/06
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.
摘要翻译： 本文描述了调节激酶活性的化合物和药物组合物，包括突变型EGFR和突变型HER2激酶活性，以及化合物，药物组合物和治疗与激酶活性相关的疾病和病症（包括突变型EGFR和突变型HER2活性）的方法。
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公开(公告)号：EP2841062A1
公开(公告)日：2015-03-04
申请号：EP13782134.4
申请日：2013-03-12
申请人： ARIAD PHARMACEUTICALS, INC. , Gozgit, Joseph M. , Rivera, Victor M. , Shakespeare, William C. , Zhu, Xiaotian , Dalgarno, David C.
发明人： GOZGIT, Joseph, M. , RIVERA, Victor, M. , SHAKESPEARE, William, C. , ZHU, Xiaotian , DALGARNO, David, C.
IPC分类号： A61K31/165
CPC分类号： C07D487/04 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/5025 , A61K31/5377 , C07D471/04 , C07D473/34
摘要： The invention discloses methods and compositions for treating or preventing RAF kinase mediated diseases or conditions by administering a compound of Formula 1: or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein.
摘要翻译： 本发明公开了通过施用式1的化合物或其药学上可接受的盐，溶剂化物或水合物来治疗或预防RAF激酶介导的疾病或病症的方法和组合物，其中变量如本文所定义。
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公开(公告)号：EP2407473A3
公开(公告)日：2012-03-21
申请号：EP11180546.1
申请日：2003-02-03
IPC分类号： C07F9/6561 , A61K45/06
CPC分类号： A61K45/06 , A61K31/675 , C07F9/6561
摘要： The invention concerns a method for producing a compound of the formula:
by reacting rapamycin with (R)(R)P(=O)-Cl or (R)(RO)P(=O)-Cl to form the compound,
wherein each occurrence of R is aryl or is an independently chosen C 1 -C 6 alkyl group optionally bearing one or more halo, -OH, alkoxyl-, alkyloxyLalkyloxyl-, haloalkyl-, hydroxyalkoxyl-, acyl-, acyloxy-, heterocyclic, aryl or heteroaryl substituents.-
公开(公告)号：EP1514931B1
公开(公告)日：2010-04-21
申请号：EP04026560.5
申请日：1995-05-30
IPC分类号： C12N15/12 , C12N15/31 , C12N15/62 , C12N15/81 , C12N1/19 , C07K14/47 , C07K14/40 , C07K16/18 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5091 , A01K2217/05 , C07K14/40 , C07K14/4702 , C07K2319/00 , C12N9/1205 , C12N9/93 , C12Q1/25 , C12Q1/6883 , C12Q1/6897 , C12Q2600/158 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N33/9493 , G01N2500/00
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公开(公告)号：EP1940843A2
公开(公告)日：2008-07-09
申请号：EP06813381.8
申请日：2006-08-11
发明人： WANG, Yihan , HUANG, Wei-Sheng , SUNDARAMOORTHI, Rajeswari , ZHU, Xioatian , THOMAS, R., Matthew , SHAKESPEARE, William, C. , DALGARNO, David, C. , SAWYER, Tomi, K.
IPC分类号： C07D473/40 , C07D473/18 , C07D473/34 , A61K31/52 , A61K31/522 , A61K31/675 , A61K31/5377 , C07F9/6561 , A61P35/00 , A61P35/02
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which Q is an ethynyl or ethenyl moiety; Ring A is an aryl, heteroaryl or heterocyclic ring or ring system; and the remaining variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：EP1259520B1
公开(公告)日：2006-05-24
申请号：EP00986551.0
申请日：2000-12-18
发明人： WEIGELE, Manfred , SHAKESPEARE, William , SAWYER, Tomi, K. , SUNDARAMOORTHI, Rajeswari , BOHACEK, Regine , WANG, Yihan , METCALF, Chester, A., III , DALGARNO, David, C.
IPC分类号： C07F9/6561
CPC分类号： C07D471/04 , A61K47/548 , C07D487/04 , C07F9/4012 , C07F9/405 , C07F9/6561 , C07F9/65616
摘要： Novel phosphorous moieties containing purines and uses of these compounds for the treatment of bone related disorders and cancer is disclosed.
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