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公开(公告)号：EP0339667A2
公开(公告)日：1989-11-02
申请号：EP89107762.0
申请日：1989-04-28
发明人： Kuzuhara, Syoji , Odo, Koichi , Mizuno, Kyosuke
IPC分类号： A61K39/29 , A61K39/295
CPC分类号： A61K39/29 , A61K39/12 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , Y02A50/464
摘要： A hepatitis A,B-combined adjuvanted vaccine is disclosed in this application, said vaccine comprising an inactivated hepatitis A virus antigen, a hepatitis B virus surface antigen and an adjuvant. The present vaccine is obtained by causing the antigens to be adsorbed to the adjuvant. According to the present invention, the infection with not only hepatitis A virus but also hepatitis B vrius can be prevented without causing any interference due to the mixing of these antigens and any severe side-effects, and the anti-hepatitis A virus antibody titer is greatly enhanced by the mixing.
摘要翻译： 在本申请中公开了甲型肝炎乙型联合佐剂疫苗，所述疫苗包含灭活的甲型肝炎病毒抗原，乙型肝炎病毒表面抗原和佐剂。 通过使抗原吸附到佐剂上获得本疫苗。 根据本发明，可以防止由于这些抗原的混合引起的任何干扰和任何严重的副作用，而且不仅甲型肝炎病毒而且乙型肝炎病毒的感染，并且抗甲型肝炎病毒抗体滴度为 通过混合大大增强。
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42.发明公开Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation 失效编码由这些嵌合抗-HIV抗体和它们的制备方法表示的抗HIV抗体的可变区基因片段。
公开(公告)号：EP0327000A2
公开(公告)日：1989-08-09
申请号：EP89101583.6
申请日：1989-01-30
发明人： Maeda, Hiroaki , Eda, Yasuyuki , Kimachi, Kazuhiko , Tokiyoshi, Sachio , Matsushita, Shuzo , Hattori, Toshio , Takatsuki, Kiyoshi
IPC分类号： C12N15/13 , A61K39/395 , C12N5/10 , C12P21/08
CPC分类号： C07K16/1063 , A61K38/00 , C07K2317/24
摘要： Described are novel chimeric anti-human immunodeficiency virus (HIV) antibodies which comprise a constant region derived from human antibody and variable region derived from mouse monoclonal antibody, gene fragments coding for the variable region the H and L chain of chimeric anti-HIV antibodies which are effective for expression of chimeric anti-HIV antibodies having an HIV-neutralizing activity, a transformant where such gene fragments are incorporated, chimeric anti-HIV antibodies expressed therefrom and a process for their preparation. The chimeric anti-HIV antibodies of the present invention show anti-HIV neutralizing activity and are useful for the diagnosis, treatment and prevention of acquired immunodeficiency syndrome (AIDS) caused by HIV without side effects such as anaphylactic shock or serum sickness.
摘要翻译： 描述的是新颖的，其包括来自人抗体和小鼠单克隆抗体的可变区的恒定区的嵌合抗 - 人免疫缺陷病毒（HIV）抗体，基因片段编码嵌合抗-HIV抗体的H和L链的可变区，其 有效用于具有HIV中和活性，其中一个检查基因片段掺入转化体，从那里过表达嵌合抗HIV抗体和用于制备它们的方法的嵌合抗-HIV抗体的表达。 本发明显示抗HIV中和活性的和嵌合的抗HIV抗体可用于无副作用由HIV引起的诊断，治疗和预防获得性免疫缺陷综合症的（AIDS）有用：如过敏性休克或血清病。
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公开(公告)号：EP0211223A3
公开(公告)日：1989-05-03
申请号：EP86108802.9
申请日：1986-06-27
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute , Hirayama, Chuichi , Motozato, Yoshiaki , Ihara, Hirotaka
CPC分类号： A61K8/025 , A61K8/88 , A61K2800/412 , A61Q1/12 , B01J20/26 , B01J20/285 , C08G69/08 , C08J3/14 , C08J2377/00
摘要： The present invention provides novel spherical grains of polyamino acid which can be used as a filler in chromatography, cosmetic powder and the like. The spherical grains can be produced by a method which comprises the steps of preparing a solution of hydrophobic polyamino acids, such as poly n-leucine, dissolved in an organic solvent; adding the solution to an aqueous medium and agitating said medium so as to obtain a dispersion of the spherical grains of the polyamino acid dispersed in the aqueous medium while evaporating the organic solvent; and isolating the spherical grains of the polyamino acid from the dispersion.
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公开(公告)号：EP0179483A3
公开(公告)日：1989-03-01
申请号：EP85113585.5
申请日：1985-10-25
IPC分类号： C12P21/08
CPC分类号： C07K16/082
摘要： Disclosed are monoclonal antibodies to the HBsAg which are prepared by forming hybridomas between human peripheral blood lymphocyte cells, derived from humans having high titers of anti-HBsAg antibodies, and myeloma cells, cloning the hybridomas and selecting the antibody-producing clones. The monoclonal antibodies react with all the subtypes of the HBsAg and are very effective in diagnosis and treatment of diseases due to the viral infection.
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公开(公告)号：EP0173973A3
公开(公告)日：1988-08-10
申请号：EP85110915
申请日：1985-08-29
IPC分类号： G01N33/577 , G01N33/74 , C12P21/00 , C12R01/91
CPC分类号： G01N33/74
摘要： Described is a highly sensitive immunoassay method for determining the amounts of TSH contained in body fluids, in which an anti-β-subunit TSH monoclonal antibody having a specific association constant value is used.
摘要翻译： 描述了用于确定体液中含有的TSH的量的高度灵敏的免疫测定方法，其中使用具有特定关联常数值的抗β-亚基TSH单克隆抗体。
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46.发明公开Live vaccine for contagious diseases of chickens 失效LebendvaccinefürAnsteckungskrankheiten vonKüken。
公开(公告)号：EP0253389A1
公开(公告)日：1988-01-20
申请号：EP87110291.9
申请日：1987-07-16
发明人： Honda, Takashi , Taneno, Akira , Hanaki, Takuma , Eto, Masanobu
IPC分类号： A61K39/12 , A61K39/245 , A61K39/255 , A61K39/295
CPC分类号： A61K39/255 , A61K39/12 , A61K39/245 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N2710/16334 , Y10S424/816
摘要： A live vaccine for infectious laryngotracheitis, which comprises culture cells infected with attenuated infectious laryngotracheitis virus. Also, a live combined vaccine for infectious laryngotracheitis and Marek's disease, which comprises culture cells infected with attenuated viruses of these two diseases. These vaccines can be used on day-old (newborn) chicken, by subcutaneous or intramuscular injection, to give them immunity from infection by the virus or viruses.
摘要翻译： 用于传染性喉气管炎的活疫苗，其包含感染减毒感染性喉气管炎病毒的培养细胞。 另外，用于传染性喉气管炎和马立克氏病的活联合疫苗包括感染这两种疾病的减毒病毒的培养细胞。 这些疫苗可以通过皮下或肌内注射用于日龄（新生儿）鸡，使其免受病毒或病毒的感染。
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公开(公告)号：EP0171765A3
公开(公告)日：1988-01-13
申请号：EP85110011
申请日：1985-08-08
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , C12N2770/24134 , C12N2770/24151 , Y02A50/39
摘要： Disclosed is an improved method for the purification of Japanese encephalitis virus, which comprises subjecting a solution containing the Japanese encephalitis virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified Japanese encephalitis virus, which is useful for obtaining an effective vaccine against Japanese encephalitis.
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公开(公告)号：EP0140386A3
公开(公告)日：1987-03-04
申请号：EP84113134
申请日：1984-10-31
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/822
摘要： Described is a method for producing highly pure LPF-HA (Leucocytosis-promoting Factor Hemagglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this invention is highly pure and contains almost no endotoxin of B. pertussis and is useful for the preparation of various reagents utilizing the physiological activities, of a medicine for treating diabetes and of a pertussis vaccine.
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公开(公告)号：EP0193154A2
公开(公告)日：1986-09-03
申请号：EP86102363.8
申请日：1986-02-24
CPC分类号： G01N33/545 , G01N33/5438
摘要： Disclosed is a potential-causing element, in the form of an electrode or a membrane, for use in immunosensors, which comprises a polypyrrole or polythiophene film bound with an antigen or an antibody. The potential-causing element can be prepared in an easy manner through electrolytic polymerization of pyrrole or thiopene so as to control the thickness of the polymer film which will develop desired immunosresponse characteristics.
摘要翻译： 公开了用于免疫传感器的电极或膜形式的潜在的元素，其包含与抗原或抗体结合的聚吡咯或聚噻吩膜。 可以通过吡咯或噻吩的电解聚合以容易的方式制备潜在的元素，以便控制将产生所需免疫应答特性的聚合物膜的厚度。
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50.发明公开Nonspecific-reaction inhibitor in an immunological assay with monoclonal antibody 无效使用单克隆抗体在免疫学测试非特异性反应抑制剂。
公开(公告)号：EP0174026A2
公开(公告)日：1986-03-12
申请号：EP85111223.5
申请日：1985-09-05
发明人： Tsuji, Ichiroh , Unoki, Masanori , Aoyama, Noriaki
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , G01N33/5306
摘要： Disclosed are certain animal sera and ascites that are useful for inhibiting the nonspecific-reactions occuring when carrying out an immunological assay with monoclonal antibodies (MCA). The use of the inhibitor makes the assay very accurate.
摘要翻译： 本发明公开了某些动物血清和腹水做是有用的用于抑制非特异性-反应存在的当用单克隆抗体（MCA）的免疫学测定进行。 使用抑制剂的使测定非常准确。
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