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107 条记录 (耗时 0.02 秒)

    A METHOD OF DIAGNOSIS AND AGENTS USEFUL FOR SAME
    41.
    发明公开
    A METHOD OF DIAGNOSIS AND AGENTS USEFUL FOR SAME 审中-公开
    DIAGNOSEVERFAHREN UNDDAFÜRGEEIGNETE AGENTIEN

    公开(公告)号：EP2082235A4

    公开(公告)日：2009-12-02

    申请号：EP07815354

    申请日：2007-10-11

    申请人： MEDVET SCIENCE PTY LTD

    发明人： BROWN MICHAEL PAUL ,  AL-EJEH FARES ,  DARBY JOCELYN MARGARET

    IPC分类号： G01N33/574 ,  C12Q1/68 ,  G01N33/68

    CPC分类号： G01N33/57496 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2800/52

    摘要： The present invention relates generally to a method of screening for a neoplastic cell in a subject. More particularly, the present invention provides a method of screening for both viable neoplastic cells and, still further, cytotoxin induced neoplastic cell death by detecting the level of expression of La protein and/or gene by a cellular population in said subject or in a biological sample derived from said subject. The method of the present invention is useful in a range of applications including, but not limited to, diagnosing, prognosing or assessing a neoplastic condition, monitoring the progression of such a condition, assessing the effectiveness of a therapeutic agent or therapeutic regime and predicting the likelihood of a subject either progressing to a more advanced disease state or entering a remissive state. The present invention also provides diagnostic agents useful for detecting La protein and/or nucleic acid molecules.

    摘要翻译： 本发明一般涉及筛选受试者中的肿瘤细胞的方法。 更具体地，本发明提供了通过检测所述受试者中的细胞群体或生物学中的La蛋白和/或基因的表达水平来筛选活的肿瘤细胞和进一步细胞毒素诱导的赘生性细胞死亡的方法 来自所述受试者的样品。 本发明的方法可用于一系列应用，包括但不限于诊断，预后或评估肿瘤状况，监测这种病症的进展，评估治疗剂或治疗方案的有效性并预测 受试者进展到更晚期的疾病状态或进入缓解状态的可能性。 本发明还提供了可用于检测La蛋白和/或核酸分子的诊断剂。

    MONOCLONAL ANTIBODY INHIBITOR OF GM-CSF, IL-3, IL-5 AND OTHER CYTOKINES, AND USES THEREOF
    49.
    发明授权
    MONOCLONAL ANTIBODY INHIBITOR OF GM-CSF, IL-3, IL-5 AND OTHER CYTOKINES, AND USES THEREOF 有权
    一种单克隆抗体，如GM-CSF的抑制剂，IL-3，IL-5和其它细胞因子及其用途

    公开(公告)号：EP1105426B1

    公开(公告)日：2005-05-11

    申请号：EP99941314.9

    申请日：1999-08-13

    申请人： MEDVET SCIENCE PTY. LTD.

    发明人： LOPEZ, Angel, Hanson Centre for Cancer Research ,  D'ANDREA, Richard, Hanson Ctr. for Cancer Res.

    IPC分类号： C07K16/24 ,  C07K16/28

    CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/73

    摘要： A method of isolating a monoclonal antibody capable of inhibiting any one of IL-3, GM-CSF and IL-5 binding to the common receptor beta c, or a monoclonal antibody capable of inhibiting the cytokines binding to a receptor analogous to beta c. The method includes the steps of immunising an animal with a cytokine receptor or portion of a cytokine containing the critical binding site which portion includes the extracellular domain 4 or analogous domain in the analogous common receptor or part thereof. Antibodies producing cells from the animal are then isolated and fused with a myeloma cell line and then screened for a cell line that produces an antibody of the desired type. A monoclonal antibody, or fragments thereof capable of inhibiting the binding of the cytokines IL-3, GM-CSF and IL-5 to the beta c receptor, and a hybridoma cell line producing the antibody are also claimed.