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公开(公告)号：EP1290182B1
公开(公告)日：2010-12-22
申请号：EP01929118.6
申请日：2001-05-11
发明人： VADAS, Mathew , GAMBLE, Jennifer , XIA, Pu , WANG, Lijun
IPC分类号： A61K31/133 , A61P35/00
CPC分类号： C12N9/1205 , A61K31/13 , A61K38/00
摘要： The present invention relates generally to a method of modulating the growth of cells and, more particularly, to a method of down-regulating the growth of neoplastic cells. The present invention is useful, inter alia, in the therapeutic and/or prophylactic treatment of cancers such as, but not limited to, solid cancers such as cancers of the colon, stomach, lung, brain, bone, oesophagus, pancreas, breast, ovary or uterus.
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公开(公告)号：EP2438167A1
公开(公告)日：2012-04-11
申请号：EP10782840.2
申请日：2010-06-04
申请人： Centenary Institute Of Cancer Medicine And Cell Biology , The University Of Sydney , MEDVET SCIENCE PTY. LTD. , Wenkart Foundation
IPC分类号： C12N15/113 , A61P9/10 , C07H21/02 , A61K48/00 , A61P35/00
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/7105 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2800/7014
摘要： The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
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3.发明公开A METHOD OF MODULATING EPITHELIAL CELL ACTIVITY BY MODULATING THE FUNCTIONAL LEVELS OF SPHINGOSINE KINASE 审中-公开调制ENDOTHELZELLAKTIVITÄT方法由穿梭鞘氨醇功能水平的变化
公开(公告)号：EP1558736A1
公开(公告)日：2005-08-03
申请号：EP03750156.6
申请日：2003-10-14
CPC分类号： C12N9/1205 , A61K38/45 , C12N2799/022
摘要： The present invention relates generally to a method of modulating endothelial cell functional characteristics and to agents useful for same. More particularly, the present invention relates to a method of modulating vascular endothelial cell pro-inflammatory and angiogenic phenotypes by modulating the functional levels of intracellular sphingosine kinase. The method of the present invention is useful, inter alia, in relation to the treatment and/or prophylaxis of conditions which are characterised by inadequate endothelial cell functioning and may include conditions such as vascular engraftment, organ transplantation or wound healing or conditions which are characterised by an aberrant endothelial cell inflammatory or angiogenic phenotype. Further, the method of the present invention facilitates the development of agents, such as functionally manipulated endothelial cell populations, for a range of therapeutic and/or prophylactic uses.
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4.发明公开A METHOD OF MODULATING PRO-INFLAMMATORY AND INFLAMMATORY ACTIVITY MEDIATED BY C-REACTIVE PROTEIN 审中-公开对于调制方法BY C反应蛋白介导的炎症反应和炎症活动
公开(公告)号：EP1713462A1
公开(公告)日：2006-10-25
申请号：EP05700103.4
申请日：2005-01-21
发明人： XIA, Pu , WADHAM, Carol , VADAS, Mathew
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/20 , A61K31/66 , A61K31/685
摘要： The present invention relates generally to a method of modulating the proinflammatory activity of C-reactive protein in endothelial cells. More particularly, the present invention relates to down-regulation of proinflammatory activity of C-reactive protein in vascular endothelial cells. Accordingly, the method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of inflammatory conditions, particularly conditions characterised by proinflammatory activity of C-reactive protein in endothelial cells.
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5.发明公开SPHINGOSINE KINASE INTERACTS WITH TRAF2 AND MODULATES TUMOR NECROSIS FACTOR-INDUCED CELLULAR ACTIVITY 审中-公开鞘氨醇激酶与TRAF2相互作用并调制该肿瘤坏死因子诱导的细胞活性
公开(公告)号：EP1404364A1
公开(公告)日：2004-04-07
申请号：EP02732213.0
申请日：2002-06-03
发明人： XIA, Pu , WANG, Lijun , VADAS, Mathew , GAMBLE, Jennifer , MORETTI, Paul , PITSON, Stuart
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/7151
摘要： The present invention relates generally to a method of modulating cytokine-mediated cellular activity and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated cellular activity by modulating an intracellular sphingosine kinase-dependent signalling mechanism. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cytokine-mediated cellular activity The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject sphingosine kinase-dependent signalling mechanism.
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公开(公告)号：EP1290182A1
公开(公告)日：2003-03-12
申请号：EP01929118.6
申请日：2001-05-11
发明人： VADAS, Mathew , GAMBLE, Jennifer , XIA, Pu , WANG, Lijun
CPC分类号： C12N9/1205 , A61K31/13 , A61K38/00
摘要： The present invention relates generally to a method of modulating the growth of cells and, more particularly, to a method of down-regulating the growth of neoplastic cells. The present invention is useful, inter alia, in the therapeutic and/or prophylactic treatment of cancers such as, but not limited to, solid cancers such as cancers of the colon, stomach, lung, brain, bone, oesophagus, pancreas, breast, ovary or uterus.
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公开(公告)号：EP1011654A1
公开(公告)日：2000-06-28
申请号：EP98941157.4
申请日：1998-09-08
发明人： VADAS, Mathew , GAMBLE, Jennifer , XIA, Pu , BARTER, Philip , RYE, Kerry-Anne , WATTENBERG, Brian , PITSON, Stuart
CPC分类号： G01N33/5308 , A61K38/1709 , A61K38/45 , C12Q1/34 , A61K31/66 , A61K2300/00
摘要： The present invention relates generally to a method of modulating cellular activity and agents useful for same. More particularly, the present invention contemplates a method of modulating endothelial cell activity and even more particularly endothelial cell adhesion molecule expression. Most particularly, the present invention provides a method of treating coronary heart disease by preventing or reducing endothelial cell adhesion molecule expression.
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