公开(公告)号：EP1663205A1

公开(公告)日：2006-06-07

申请号：EP04766644.1

申请日：2004-08-31

申请人： Solvay Pharmaceuticals GmbH

发明人： ANTEL, Jochen ,  KRAUSE, Günter ,  LANGE, Josephus, Hubertus, Maria ,  KRUSE, Cornelis, Gerrit ,  GREGORY, Peter-Colin ,  DEN BESTEN, Cathaline

IPC分类号： A61K31/415 ,  A61K31/4155 ,  A61K31/4439 ,  A61P3/04 ,  A61P25/00

CPC分类号： A61K31/05 ,  A61K31/352 ,  A61K31/397 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/435 ,  A61K31/4439

摘要： The present invention relates to a novel medical use of 4,5-dihydro-1H-pyrazole compounds which are potent antagonists of the cannabis CB1-receptor. Said compounds are particularly suitable in the manufacture of medicaments for the treatment and/or prophylaxis of CB1 receptor related diseases in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile as well as in adolescent patients. The compounds have the general formula (1), wherein the group Bb represents sulfonyl or carbonyl, and the substituents R, R1, R2and R3, and the group Aa are defined as shown in the description.

公开(公告)号：EP1307210B1

公开(公告)日：2006-06-07

申请号：EP01955372.6

申请日：2001-07-26

申请人： Solvay Pharmaceuticals GmbH

发明人： AHNSORGE, Jürgen ,  BAN, Ivan ,  RASCHE, Heinz-Helmer

IPC分类号： A61K35/00 ,  C07J75/00

CPC分类号： C07J1/00 ,  C07J75/00

摘要： The invention relates to a method and a device for concentrating and stabilising conjugated oestrogens from the urine of pregnant mares on solid supports in order to obtain a suitable starting material for producing pharmaceuticals that contain the natural mixture of these conjugated oestrogens as the active component. The inventive device is characterised by its suitability for practical, decentralised concentration and stabilisation of mixtures of conjugated oestrogens (CE) contained in the urine (PMU) of pregnant mares on a solid support (= adsorbent), especially in the proximity of the stable or field, in a column or a cartridge. The adsorber columns can be filled directly at the site of urine collection with the device. As a result, it is no longer necessary to transport large quantities of urine liquid daily to a central processing point. The filling process can take place continuously over a longer period of up to several weeks, until the adsorber column or cartridge is saturated. The leftover urine that runs off remains at the site, where suitable devices for disposal are already available. Only the filled column or cartridge is transported and the transport can take place at longer intervals and take longer, e.g., up to a few weeks. The excellent stability of the CE on the adsorber ensures that there is no risk of decomposition.

公开(公告)号：EP1651962A1

公开(公告)日：2006-05-03

申请号：EP04741266.3

申请日：2004-07-26

申请人： Solvay Pharmaceuticals GmbH

发明人： POTTHOFF, Andreas ,  KÖRNER, Andreas ,  THUMBECK, Bernd

IPC分类号： G01N33/573

CPC分类号： C12Q1/34 ,  G01N2333/916 ,  G01N2333/924 ,  G01N2333/95 ,  G01N2333/994

摘要： The present invention concerns a novel method to analyze identity, protein and/or peptide pattern and as well the stability of samples containing physiologically acceptable enzyme mixtures with lipolytic, proteolytic and amylolytic activity, but especially of mixtures of digestive enzymes such as pancreatin, in particular in the context of the manufacture of medicinal products comprising said enzyme mixtures, e.g. precipitated pancreatin or pancreatin mini-­microspheres.

公开(公告)号：EP0899264B1

公开(公告)日：2005-11-23

申请号：EP98115651.6

申请日：1998-08-20

申请人： Solvay Pharmaceuticals GmbH

发明人： David, Samuel ,  Antel, Jochen ,  Brückner, Reinhard ,  Ziegler, Dieter ,  Eeckout, Christian ,  Bielenberg, Gerhard-Wilhelm ,  Peck, Michael

IPC分类号： C07D243/08 ,  A61K31/55

CPC分类号： C07D243/08 ,  Y02P20/55

公开(公告)号：EP1517688A2

公开(公告)日：2005-03-30

申请号：EP03760622.5

申请日：2003-06-16

申请人： Solvay Pharmaceuticals GmbH

发明人： RUPP, Heinz ,  EISELE, Bernd ,  ZIEGLER, Dieter ,  JÄGER, Bodo ,  MAISCH, Bernhard

IPC分类号： A61K31/421 ,  A61K31/506 ,  A61K31/47 ,  A61K31/496 ,  A61P19/00 ,  A61P1/00 ,  A61P25/00

CPC分类号： A61K31/4178 ,  A61K31/421 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506

摘要： Disclosed is the use of selective imidazoline receptor agonists, particularly moxonidine, rilmenidine, LNP-509, S-23515, PMS-812, PMS-847, and BU-98008, and the physiologically acceptable salts thereof, for the production of pharmaceutical preparations used for treating and/or preventing functional disturbances and/or diseases in larger mammals or humans, which require inhibition or a reduction in the activity of proteins that regulate the intracellular pH value and belong to the superfamily of bicarbonate transporters, particularly diseases which affect the bones as a result of an undesired bone resorption level, especially osteoporosis, diseases of the gastrointestinal tract, especially gastric ulcers, and neural and/or neuropsychiatric diseases that are related to a pathologically modified, preferably an increased, neural activity, preferably depression, Alzheimer's, eating disorders, and schizophrenia.

公开(公告)号：EP1150680B1

公开(公告)日：2005-01-12

申请号：EP00902638.6

申请日：2000-01-28

申请人： Solvay Pharmaceuticals GmbH

发明人： SCHOEMAKER, Regina, Gertruida

IPC分类号： A61K31/506 ,  A61P9/10

CPC分类号： A61K31/506 ,  Y10S514/821

摘要： The invention relates to the use of moxonidine and the physiologically compatible acid additional salts thereof for producing pharmaceutical preparations for the treatment of myocardial infarction damages of the myocardium. Moxonidine and pharmaceutical preparations which contain physiologically compatible acid additional salts of moxonidine are suitable for use in acute myocardial infarction treatment and/or postmyocardial infarction treatment.

公开(公告)号：EP1450793A2

公开(公告)日：2004-09-01

申请号：EP02799727.9

申请日：2002-11-25

申请人： Solvay Pharmaceuticals GmbH

发明人： SCHRADER, Joachim

IPC分类号： A61K31/4184

CPC分类号： A61K31/00 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/435 ,  A61K45/06

摘要： The invention relates to the use of a substance for inhibiting the renin-angiotensin system during the treatment of acute cerebrovascular accident.

公开(公告)号：EP1434586A1

公开(公告)日：2004-07-07

申请号：EP02785133.6

申请日：2002-09-25

申请人： Solvay Pharmaceuticals GmbH

发明人： SCHWANITZ, Diethard ,  ROGOLL, Jutta ,  HACHMEISTER, Bernd

IPC分类号： A61K31/565 ,  A61K31/57 ,  A61P15/00

CPC分类号： A61K45/06 ,  A61K31/565 ,  A61K31/57 ,  A61K2300/00

摘要： The invention relates to novel estrogen/gestagen combination preparations for application in hormone replacement therapy, for example, for application in menopausal or climacteric complaints.

公开(公告)号：EP1424337A1

公开(公告)日：2004-06-02

申请号：EP02026237.4

申请日：2002-11-26

申请人： Solvay Pharmaceuticals GmbH

发明人： Brückner, Reinhard ,  Eeckhout, Christian ,  Finner, Emil ,  Fritsch, Holger ,  Ronken, Eric ,  Roest, Marco ,  Sann, Holger ,  Schmidt, Jochen ,  Vandermeij, Paul

IPC分类号： C07D471/06 ,  A61K31/437 ,  A61P1/08

CPC分类号： C07D401/06

摘要： The present invention relates to novel 4-hydroxy derivatives of 5,6,9,10-tetrahydro-10-[(2-methyl-1 H -imidazol-1-yl)methyl]-4 H -pyrido-[3,2,1-jk]-carbazol-11(8 H )-one with 5-HT 3 -receptor antagonistic activity. Furthermore, the invention relates to a process for the preparation of the novel derivatives.

摘要翻译： 本发明涉及5,6,9,10-四氢-10-Ä（2-甲基-1H-咪唑-1-基）甲基-4H-吡啶并[3,1,1-jkÜ 咔唑-11（8H） - 酮与5-HT 3 - 受体拮抗活性。 此外，本发明涉及一种制备新型衍生物的方法。

公开(公告)号：EP1392679A1

公开(公告)日：2004-03-03

申请号：EP02754561.5

申请日：2002-05-04

申请人： Solvay Pharmaceuticals GmbH

发明人： JASSERAND, Daniel ,  ANTEL, Jochen ,  PREUSCHOFF, Ulf ,  BRÜCKNER, Reinhard ,  SANN, Holger ,  WURL, Michael ,  EICKELMANN, Peter

IPC分类号： C07D401/06 ,  C07D405/14 ,  A61K31/454 ,  A61P1/04 ,  A61P1/06

CPC分类号： C07D401/06 ,  C07D211/32 ,  C07D405/14

摘要： The invention relates to novel, motilin-agonistically active compounds of general formula I, wherein R?1, R2, R3¿, Ar and n have the meaning as cited in the description. The invention also relates to medicaments containing said compounds and to a method for producing the novel compounds and intermediate products according to said method.