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47 条记录 (耗时 0.037 秒)

    SUBSTITUTED THIAZOLOPYRIMIDINES
    42.
    发明公开
    SUBSTITUTED THIAZOLOPYRIMIDINES 审中-公开
    替代噻唑吡嗪

    公开(公告)号：EP2964656A1

    公开(公告)日：2016-01-13

    申请号：EP14707408.2

    申请日：2014-03-03

    申请人： Bayer Pharma Aktiengesellschaft

    发明人： KLAR, Ulrich ,  WORTMANN, Lars ,  GRAHAM, Keith ,  PUEHLER, Florian ,  SÜLZLE, Detlef ,  KETTSCHAU, Georg ,  LIENAU, Philip

    IPC分类号： C07D513/04 ,  A61K31/519 ,  A61P35/00

    CPC分类号： A61K31/497 ,  C07D239/70 ,  C07D513/04

    摘要： The present invention relates to substituted thiazolopyrimidine compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及如本文所述和定义的通式I的取代的噻唑并嘧啶化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物的用途 制造用于治疗或预防疾病，特别是过度增殖和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。

    SUBSTITUTED BENZOTHIENOPYRIMIDINES
    45.
    发明公开
    SUBSTITUTED BENZOTHIENOPYRIMIDINES 有权
    取代苯并噻吩并嘧啶类化合物

    公开(公告)号：EP2852595A1

    公开(公告)日：2015-04-01

    申请号：EP13723163.5

    申请日：2013-05-17

    申请人： Bayer Pharma Aktiengesellschaft

    发明人： KLAR, Ulrich ,  KETTSCHAU, Georg ,  KOSEMUND, Dirk ,  PÜHLER, Florian ,  EIS, Knut ,  LIENAU, Philip ,  BÖMER, Ulf ,  SÜLZLE, Detlev ,  WORTMANN, Lars

    IPC分类号： C07D495/04 ,  A61K31/38 ,  A61P35/00

    CPC分类号： C07D495/04 ,  A61K31/38 ,  A61K31/519 ,  A61K45/06 ,  C07D519/00

    摘要： The present invention relates to substituted benzothienopyrimidine compounds of general formula I: in which R
    1a , R
    1b , R
    2a , R
    2b , and R
    2c are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式I的取代的苯并噻吩并嘧啶化合物：其中R 1a，R 1b，R 2a，R 2b和R 2c如本文所述和定义，涉及制备所述化合物的方法，涉及用于制备 所述化合物，含有所述化合物的药物组合物和组合以及所述化合物在制备用于治疗或预防疾病，特别是过度增殖和/或血管生成障碍的药物组合物中的用途，或作为 与其他活性成分组合。