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41.发明公开
公开(公告)号：EP1631235A4
公开(公告)日：2008-05-21
申请号：EP04752823
申请日：2004-05-19
IPC分类号： A61K20060101 , A61K48/00 , A61P11/06 , C12N15/113
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , Y02P20/582 , C12N2310/3525
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公开(公告)号：EP1546179A4
公开(公告)日：2007-12-19
申请号：EP03771893
申请日：2003-07-25
发明人： WYATT JACQUELINE R , FREIER SUSAN M
IPC分类号： A61K38/00 , C12N15/113 , C12N15/00 , A61K48/00 , C07H21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of polo-like kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding polo-like kinase. Methods of using these compounds for modulation of polo-like kinase expression and for treatment of diseases associated with expression of polo-like kinase are provided.
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公开(公告)号：EP1569695A4
公开(公告)日：2006-12-06
申请号：EP03789763
申请日：2003-11-13
IPC分类号： A61K38/00 , C12N15/113 , A61K48/00 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
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公开(公告)号：EP1397516A4
公开(公告)日：2005-05-11
申请号：EP02746328
申请日：2002-05-01
发明人： BAKER BRENDA F , FREIER SUSAN M
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/85
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p40 subunit. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p40 subunit. Methods of using these compounds for modulation of Interleukin 12 p40 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p40 subunit are provided.
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45.发明公开
公开(公告)号：EP1436308A4
公开(公告)日：2005-05-04
申请号：EP02776002
申请日：2002-09-26
发明人： BENNETT FRANK C , FREIER SUSAN M
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C12N5/02 , C12N15/113 , C12N15/85 , C07H21/02 , C12N15/11 , C12N15/86 , C12P19/34
CPC分类号： C12N15/1137 , A61K38/00 , B23Q2011/0808 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of IL-1 receptor-associated kinase-4. The compositions comprise antisense compounds, particularly antisense obligonucleotides, targeted to nucleic acids encoding IL-1 receptor-associated kinase-4. Methods of using these compounds for modulation of IL-1 receptor-associated kinase-4 expression and for treatment of diseases associated with expression of IL-1 receptor-associated kinase-4 are provided.
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公开(公告)号：EP1283908A4
公开(公告)日：2003-08-06
申请号：EP01932881
申请日：2001-05-02
IPC分类号： C07H21/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , C07H21/00 , C12Q1/6811
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47.发明公开IDENTIFICATION OF GENETIC TARGETS FOR MODULATION BY OLIGONUCLEOTIDES AND GENERATION OF OLIGONUCLEOTIDES FOR GENE MODULATION 有权调制基因靶向由调制基因的寡核苷酸及其生产OLIGONUCLEOTIDES鉴定
公开(公告)号：EP1071826A4
公开(公告)日：2003-05-21
申请号：EP99922713
申请日：1999-04-13
发明人： COWSERT LEX M , BAKER BRENDA F , MCNEIL JOHN , FREIER SUSAN M , SASMOR HENRI M , BROOKS DOUGLAS G , OHASHI CARA , WYATT JACQUELINE R , BORCHERS ALEXANDER H , VICKERS TIMOTHY A
IPC分类号： C12N15/09 , C07B61/00 , C12N15/10 , C12Q1/68 , C40B30/02 , C40B40/02 , C40B50/02 , C40B50/06 , G06F17/30 , G06F17/50 , G06F19/18 , G06F19/22 , C12N15/11 , G06F19/00
CPC分类号： G06F19/18 , B01J2219/007 , C40B50/02 , G06F19/22
摘要： Iterative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.
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