公开(公告)号：EP2714058A1

公开(公告)日：2014-04-09

申请号：EP12793424.8

申请日：2012-06-04

申请人： Mesoblast, Inc. ,  Central Adelaide Local Health Network Inc

发明人： KOBLAR, Simon Andrea ,  GRONTHOS, Stan ,  ARTHUR, Agnieszka

IPC分类号： A61K35/28 ,  C12N5/077 ,  C12N5/0789 ,  A61P25/14

CPC分类号： A61K35/28 ,  A61K9/0085 ,  A61K38/00 ,  A61K38/195 ,  A61K2035/124 ,  C12N5/0663 ,  C12N5/0664

摘要： The present disclosure provides methods of improving cerebral function or preventing loss of cerebral function and/or treating or preventing a movement disorder and/or regenerating cerebral neurons in a subject who has suffered a stroke, the method comprising administering to the subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：EP2714057A1

公开(公告)日：2014-04-09

申请号：EP12792873.7

申请日：2012-06-04

申请人： Mesoblast, Inc.

发明人： BERNARD, Claude

IPC分类号： A61K35/28 ,  A61P37/06 ,  C12N5/077 ,  C12N5/0789

摘要： The present disclosure provides a method for treating an inflammatory neurological disease comprising administering a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：EP2709634A1

公开(公告)日：2014-03-26

申请号：EP12785672.2

申请日：2012-05-18

申请人： Mesoblast, Inc.

发明人： KRISHNAN, Ravi ,  ITESCU, Silviu

IPC分类号： A61K35/12 ,  A61P3/04 ,  A61K35/28 ,  C12N5/077

摘要： The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.

摘要翻译： 本公开提供了治疗或预防肥胖症或引起体重减轻或治疗或预防代谢综合征的方法，包括向受试者施用富集STRO-1 +细胞和/或其后代和/或由其衍生的可溶性因子的细胞群。

公开(公告)号：EP2593115A4

公开(公告)日：2013-12-04

申请号：EP11799996

申请日：2011-07-04

申请人： MESOBLAST INC

发明人： ITESCU SILVIU ,  SCHUSTER MICHAEL DAVID

IPC分类号： A61K35/28 ,  A61P37/06 ,  C12N5/077 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K45/06 ,  A61K2035/122 ,  C12N5/0663

摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.

摘要翻译： 一种预防哺乳动物患者发展或治疗GvHD并发症的方法，该方法包括给哺乳动物施用富含STRO-1亮细胞和/或其后代和/或由其衍生的可溶性因子的细胞群。

公开(公告)号：EP2408904A4

公开(公告)日：2013-02-27

申请号：EP10753012

申请日：2010-03-22

申请人： MESOBLAST INC

发明人： ITESCU SILVIU

IPC分类号： C12N5/077 ,  C12N15/06 ,  C12N15/07

CPC分类号： C12N5/0696 ,  C12N15/86 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/1353 ,  C12N2506/1361 ,  C12N2506/1384 ,  C12N2510/00 ,  C12N2740/15043 ,  G01N33/5073

摘要： The present invention provides a method of producing a reprogrammed cell, said method comprising exposing Stro-1+ multipotential cells and/or progeny cells thereof to one or more potency-determining factors under conditions sufficient to reprogram the cells. The present invention also provides cells produced by such a method and cells differentiated therefrom in addition to various uses of those cells.

公开(公告)号：EP3366298B1

公开(公告)日：2020-08-19

申请号：EP18150570.2

申请日：2011-07-04

申请人： Mesoblast, Inc.

发明人： ITESCU, Silviu ,  SCHUSTER, Michael, David

IPC分类号： A61K35/28 ,  C12N5/077 ,  A61P37/06 ,  C12N5/0789 ,  A61P37/02 ,  C12N5/0775 ,  A61K35/12

公开(公告)号：EP2714057B1

公开(公告)日：2019-11-06

申请号：EP12792873.7

申请日：2012-06-04

申请人： Mesoblast, Inc.

发明人： BERNARD, Claude

IPC分类号： A61K35/28 ,  A61P37/06 ,  C12N5/077 ,  C12N5/0789 ,  A61K38/21 ,  C12N5/0775

公开(公告)号：EP2348105B1

公开(公告)日：2018-10-24

申请号：EP10075534.7

申请日：2005-09-26

申请人： Mesoblast, Inc.

发明人： Gronthos, Stan ,  Zannettino, Andrew Christopher William

IPC分类号： C12N5/0775

CPC分类号： C12N5/0606 ,  A61K35/28 ,  A61K38/1858 ,  A61K38/1875 ,  A61K38/191 ,  A61K38/195 ,  A61K38/2006 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3886 ,  A61L27/3895 ,  C12N5/0662 ,  C12N5/0663 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0666 ,  C12N5/0667 ,  C12N5/0668 ,  C12N2510/00 ,  A61K2300/00

摘要： This invention relates to multipotential expanded mesenchymal precursor cell progeny (MEMPs). The present invention also relates to methods for producing MEMPs and to uses of MEMPs for therapeutic applications.

公开(公告)号：EP2593114B1

公开(公告)日：2018-01-10

申请号：EP11799995.3

申请日：2011-07-04

申请人： Mesoblast, Inc.

发明人： ITESCU, Silviu ,  SCHUSTER, Michael, David

IPC分类号： A61K35/28 ,  C12N5/077 ,  A61P37/06 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K45/06 ,  A61K2035/122 ,  A61P37/02 ,  C12N5/0663

摘要： A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.

公开(公告)号：EP2931373A4

公开(公告)日：2016-05-04

申请号：EP13862590

申请日：2013-12-12

申请人： MESOBLAST INC

发明人： ITESCU SILVIU ,  KRISHNAN RAVI ,  GHOSH PETER

IPC分类号： A61P11/00 ,  A61K35/28 ,  A61P11/06 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： A61K35/28 ,  C12N5/0663

摘要： The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.