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    METHOD AND APPARATUS FOR BACTERIAL MONITORING
    42.
    发明公开
    METHOD AND APPARATUS FOR BACTERIAL MONITORING 审中-公开
    用于细菌监测的方法和设备

    公开(公告)号：EP2981814A1

    公开(公告)日：2016-02-10

    申请号：EP14773472.7

    申请日：2014-03-25

    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Technion Research & Development Foundation Ltd.

    Inventor： SA'AR, Amir ,  SEGAL, Ester

    IPC: G01N23/20 ,  G01B11/22 ,  G01D5/26

    CPC classification number: G01N33/5302 ,  G01D5/266 ,  G01N21/4738 ,  G01N21/4788 ,  G01N21/85 ,  G01N2201/0446 ,  G01N2201/061

    Abstract: A system for detecting target elements such as bacteria in a host analyte, comprising a substrate with an ordered array of wells having diameters to fit the size of the targets. The substrate may be a periodic macro-PSi array structure (MPSiAS) illuminated with a broadband source. The reflected light spectrum diffracted from the substrate is optically analyzed to provide the effective optical depth of the wells. Fast Fourier Transform analysis may be used for the optical analysis. Entry of target elements into wells is detected by the change in the effective optical depths of the wells. Micro-organisms as large as bacteria and viruses having dimensions comparable with the wavelength of the illumination can thus be detected. Wells with an inner section impenetrable by the target cells enables compensation for environmental changes. The detection may be performed in real time, such that production line bacterial monitoring may be achieved.

    Abstract translation: 一种用于检测宿主分析物中的目标元件例如细菌的系统，包括具有有序阵列的井的衬底，所述阵列具有适合目标尺寸的直径。 衬底可以是用宽带源照明的周期性宏观PSi阵列结构（MPSiAS）。 光学分析从衬底衍射的反射光谱以提供阱的有效光学深度。 快速傅立叶变换分析可以用于光学分析。 目标元素进入井中是通过井的有效光学深度的变化来检测的。 因此可以检测与尺寸与照明波长相当的细菌和病毒一样大的微生物。 具有靶细胞难以穿透的内部部分的井能够对环境变化进行补偿。 检测可以实时进行，从而可以实现生产线细菌监测。

    SAMPLE-HOLDING CARRIER AND FLUORESCENCE DETECTION DEVICE USING SAME
    43.
    发明公开
    SAMPLE-HOLDING CARRIER AND FLUORESCENCE DETECTION DEVICE USING SAME 审中-公开
    IT IT IT ER IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT

    公开(公告)号：EP2927671A1

    公开(公告)日：2015-10-07

    申请号：EP13859389.2

    申请日：2013-10-29

    Applicant: Panasonic Intellectual Property Management Co., Ltd.

    Inventor： NAGATOMI, Kenji ,  NAKATANI, Morio ,  NAKATANI, Masaya ,  OKI, Akio

    IPC: G01N21/64 ,  G01N21/03

    CPC classification number: G01N21/6486 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2300/0893 ,  B01L2300/168 ,  B01L2400/0415 ,  G01N21/03 ,  G01N21/07 ,  G01N21/6452 ,  G01N21/69 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/0612

    Abstract: [Summary] There is provided a sample-holding carrier that can efficiently irradiate a sample in a well with light and a fluorescence detection device using the same.
    [Object] A biosensor substrate (1) includes: a base substrate (11) to which excitation light is entered from an under face; a reflective film (16) disposed on the top face side of the base substrate (11) and having electrical conductivity; a plurality of wells (13) disposed on the top face side of the reflective film (16) and having a bottom face portion (13a); and a conductive ring (15) that applies a voltage to the reflective film (16) from the outside. When a sample prepared by applying fluorescence labeling to red blood cells is accommodated in the wells (13), the red blood cells are uniformly arranged on the bottom face portion (13a) by applying a positive voltage to the reflective film (16) because the red blood cells are generally negatively charged. Thus, it is possible to efficiently irradiate individual red blood cells with excitation light.

    Abstract translation: 发明内容提供了一种能够有效地用光照射井中的样品的样品保持载体和使用其的荧光检测装置。 生物传感器基板（1）包括：从底面进入激发光的基底基板（11） 反射膜（16），设置在所述基底基板（11）的顶面侧并具有导电性; 设置在所述反射膜（16）的顶面侧并具有底面部（13a）的多个孔（13）。 以及从外部向反射膜（16）施加电压的导电环（15）。 当通过对红细胞进行荧光标记制备的样品被容纳在孔（13）中时，通过向反射膜（16）施加正电压，将红细胞均匀地排列在底面部分（13a）上，因为 红细胞通常带负电荷。 因此，可以用激发光有效地照射各个红细胞。

    LED DENSITOMETER FOR MICROTITER PLATE
    44.
    发明公开
    LED DENSITOMETER FOR MICROTITER PLATE 审中-公开
    用于微型平板的LED密度计

    公开(公告)号：EP2454579A2

    公开(公告)日：2012-05-23

    申请号：EP10800172.8

    申请日：2010-07-16

    Applicant: Gold Standard Diagnostics Corp. ,  Van Praet, Peter

    Inventor： VAN PRAET, Peter

    IPC: G01N9/24 ,  G01N21/17 ,  G01N35/00

    CPC classification number: G01N21/00 ,  G01N21/253 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0627 ,  G01N2201/10

    Abstract: Light emitting diodes (LEDs) are mounted in an array to an upper structure overlying a lower structure with a plurality of light detectors thereon. Each LED is configured to overlie a separate detector. Each LED emits light at a frequency relevant for measuring optical density of a specimen. LEDs having different frequencies are included within the LED array. A corresponding array of detectors is also provided, mounted to the lower structure. Spacing between adjacent LEDs and between adjacent detectors match a spacing between wells in a microtiter plate. Spacing between the lower structure and the upper structure supporting the LEDs is sufficient for the microtiterplate to fit between. Circuitry sequentially fires individual LEDs and gathers optical density data through the detectors for specimens in the wells of the microtiter plate. The structures are then moved to a next adjacent well position on the microtiter plate and the process repeated.

    Abstract translation: 发光二极管（LED）以阵列形式安装在覆盖下部结构的上部结构上，其上具有多个光检测器。 每个LED被配置为覆盖单独的检测器。 每个LED以与测量样本光密度有关的频率发光。 具有不同频率的LED被包括在LED阵列内。 还提供了相应的检测器阵列，安装在下部结构上。 相邻LED之间以及相邻检测器之间的间距与微量滴定板中孔之间的间距相匹配。 下部结构和支撑LED的上部结构之间的间隔足以使微量滴定板适合于它们之间。 电路按顺序发射单个LED并通过检测器收集光密度数据以用于微量滴定板孔中的样本。 然后将这些结构移动到微量滴定板上的下一个相邻的孔位置并重复该过程。

    Strahlungsmessgerät, insbesondere zur Lumineszenzmessung
    47.
    发明公开
    Strahlungsmessgerät, insbesondere zur Lumineszenzmessung 失效
    辐射测量装置，特别是用于测量发光

    公开(公告)号：EP0523521A3

    公开(公告)日：1994-09-14

    申请号：EP92111536.6

    申请日：1992-07-08

    Applicant: Laboratorium Prof. Dr. Rudolf Berthold GmbH & Co.

    Inventor： Berthold, Fritz, Dr. ,  Lohr, Willy

    IPC: G01N35/02 ,  G01N21/76

    CPC classification number: G01N35/028 ,  G01N21/76 ,  G01N2035/1062 ,  G01N2201/0446 ,  G01N2201/0646 ,  G01N2201/08

    Abstract: Ein Strahlungsmeßgerät zur automatischen Messung mehrerer matrixartig angeordneter Probengefäße (21), beispielsweise einer Mikrotiter-Platte, weist eine stationäre Blendenplatte (10) auf, unterhalb derer unter dichtender Anpressung die Probengefäße schrittweise vorbeigeführt werden, während auf der Oberseite dieser Blendenplatte die Eintrittsblende eines Detektors (30) oder entsprechender Lichtleiterelemente angeordnet ist. Dabei wird der Detektor sukzessiv jeweils einem Probengefäß zugeordnet, wobei durch die Zwischenschaltung der Blendenplatte insbesondere erreicht wird, daß eine einwandfreie optische Abdichtung der kritischen Nahtstelle zwischen Probengefäßen einerseits und Eintrittsblende andererseits erreicht wird. Bevorzugt weist hierbei die Blendenplatte eine Lochreihe (11) in y-Richtung auf, über die die Eintrittsöffnung des Detektors (30) gleitend verschiebbar ist, wogegen die Probengefäße in x-Richtung vorbeigeführt werden. Bei dieser Ausführungsform dient hierbei die Blendenplatte als Dichtelement, Anschlagelement und Führungselement. Die mechanische Entkoppelung der beiden Bewegungen in x- und y-Richtung ermöglicht einen klaren, mechanisch übersichtlichen Aufbau des Strahlungsmeßgerätes, wobei die Anforderungen an mechanische Maßtoleranzen der betreffenden Bauteile wesentlich reduziert werden können.

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