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335 条记录 (耗时 0.014 秒)

    HUMAN HEPATITIS B VIRUS DNA
    41.
    发明公开
    HUMAN HEPATITIS B VIRUS DNA 失效
    DNS DES MENSCHLICHEN HEPATITIS B VIRUS

    公开(公告)号：EP0860505A1

    公开(公告)日：1998-08-26

    申请号：EP96935435.6

    申请日：1996-10-24

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： KINOSHITA, Moritoshi ,  KATSURAGI, Kiyonori

    IPC分类号： C12N15/51 ,  C12Q1/68 ,  G01N27/26

    CPC分类号： C12Q1/706

    摘要： A pair of PCR primers designed so that the regions 1701 to 1794 of a human hepatitis B virus are selectively amplified and represented by, for example, SEQ ID NOS: 1 and 2; and DNA fragments (standards) consisting of the regions 1701 to 1794 of a human hepatitis B virus and represented by, for example, SEQ ID NOS: 3 to 8. The use of the same makes it possible to conduct genotyping of variations in the Pre-C region of a human hepatitis B virus genome and assaying of each genotype simultaneously therewith.

    摘要翻译： 设计成使得人乙型肝炎病毒的区域1701至1794被选择性扩增并由例如SEQ ID NO：1和2表示的一对PCR引物; 和由人乙型肝炎病毒的区域1701至1794组成并由例如SEQ ID NO：3至8表示的DNA片段（标准品）。使用该DNA片段（标准）可以进行Pre -C区域，并同时测定各基因型。

    HLA-restricted hepatitis B virus CTL epitopes
    45.
    发明公开
    HLA-restricted hepatitis B virus CTL epitopes 失效
    HLA限制性HEPATITIS B病毒性CTL病毒

    公开(公告)号：EP0534615A3

    公开(公告)日：1994-05-25

    申请号：EP92307764.8

    申请日：1992-08-26

    申请人： CYTEL CORPORATION

    发明人： Vitiello, Maria A. ,  Chesnut, Robert W.

    IPC分类号： C12N15/51 ,  A61K39/29 ,  G01N33/569 ,  C07K7/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2730/10122

    摘要： Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.

    Methods and reagents for hepatitis C detection
    47.
    发明公开
    Methods and reagents for hepatitis C detection 失效
    HEPATITIS C检测方法和试剂

    公开(公告)号：EP0529493A3

    公开(公告)日：1993-07-28

    申请号：EP92114115.6

    申请日：1992-08-19

    申请人： F. HOFFMANN-LA ROCHE AG

    发明人： Resnick, Robert M. ,  Young, Karen K.Y.

    IPC分类号： C12Q1/70 ,  C12N15/51

    CPC分类号： C07K14/005 ,  C12N2770/24222 ,  C12Q1/707

    摘要： The invention provides reagents, methods and kits for amplifying and detecting U.S., Japan, and HCV-C prototype nucleic acids.Oligonucleotides primers can be used to amplify and detect Hepatitis C virus nucleic acids in a process that involves reverse transcription of the viral genomic RNA to create cDNA and the subsequent amplification of the cDNA by the polymerase chain reaction. Oligonucleotide probes can be used to detect the presence of amplified DNA by hybridization.

    HLA-restricted hepatitis B virus CTL epitopes
    49.
    发明公开
    HLA-restricted hepatitis B virus CTL epitopes 失效
    乙型肝炎病毒表位mit HLA-reduzierte CTL-Respons。

    公开(公告)号：EP0534615A2

    公开(公告)日：1993-03-31

    申请号：EP92307764.8

    申请日：1992-08-26

    申请人： CYTEL CORPORATION

    发明人： Vitiello, Maria A. ,  Chesnut, Robert W.

    IPC分类号： C12N15/51 ,  A61K39/29 ,  G01N33/569 ,  C07K7/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2730/10122

    摘要： Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.

    摘要翻译： 细胞毒性T淋巴细胞刺激肽诱导HLA受限于乙型肝炎病毒抗原的应答。 衍生自HBV表面和核衣壳抗原的CTL表位区的肽特别可用于治疗和预防HBV感染，包括治疗慢性感染的HBV携带者。 肽可以配制成HBV疫苗和药物组合物，例如用于增强HLA限制性CTL应答的含脂质组合物。 这些肽也可用于诊断方法，例如预测哪些HBV感染个体易发展为慢性感染。