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    METHOD AND APPARATUS FOR BACTERIAL MONITORING
    53.
    发明公开
    METHOD AND APPARATUS FOR BACTERIAL MONITORING 审中-公开
    用于细菌监测的方法和设备

    公开(公告)号：EP2981814A1

    公开(公告)日：2016-02-10

    申请号：EP14773472.7

    申请日：2014-03-25

    申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Technion Research & Development Foundation Ltd.

    发明人： SA'AR, Amir ,  SEGAL, Ester

    IPC分类号： G01N23/20 ,  G01B11/22 ,  G01D5/26

    CPC分类号： G01N33/5302 ,  G01D5/266 ,  G01N21/4738 ,  G01N21/4788 ,  G01N21/85 ,  G01N2201/0446 ,  G01N2201/061

    摘要： A system for detecting target elements such as bacteria in a host analyte, comprising a substrate with an ordered array of wells having diameters to fit the size of the targets. The substrate may be a periodic macro-PSi array structure (MPSiAS) illuminated with a broadband source. The reflected light spectrum diffracted from the substrate is optically analyzed to provide the effective optical depth of the wells. Fast Fourier Transform analysis may be used for the optical analysis. Entry of target elements into wells is detected by the change in the effective optical depths of the wells. Micro-organisms as large as bacteria and viruses having dimensions comparable with the wavelength of the illumination can thus be detected. Wells with an inner section impenetrable by the target cells enables compensation for environmental changes. The detection may be performed in real time, such that production line bacterial monitoring may be achieved.

    摘要翻译： 一种用于检测宿主分析物中的目标元件例如细菌的系统，包括具有有序阵列的井的衬底，所述阵列具有适合目标尺寸的直径。 衬底可以是用宽带源照明的周期性宏观PSi阵列结构（MPSiAS）。 光学分析从衬底衍射的反射光谱以提供阱的有效光学深度。 快速傅立叶变换分析可以用于光学分析。 目标元素进入井中是通过井的有效光学深度的变化来检测的。 因此可以检测与尺寸与照明波长相当的细菌和病毒一样大的微生物。 具有靶细胞难以穿透的内部部分的井能够对环境变化进行补偿。 检测可以实时进行，从而可以实现生产线细菌监测。

    APPARATUS FOR CONTROLLING MICROFLUIDIC COMPONENTS
    56.
    发明公开
    APPARATUS FOR CONTROLLING MICROFLUIDIC COMPONENTS 审中-公开
    VORRICHTUNG ZUR STEUERUNG MIKROFLUIDISCHER KOMPONENTEN

    公开(公告)号：EP2921919A1

    公开(公告)日：2015-09-23

    申请号：EP15159909.9

    申请日：2015-03-19

    申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

    发明人： Nahmias, Yaakov ,  Ezra, Elishai

    IPC分类号： G05B19/042 ,  G06F19/00

    CPC分类号： G05D7/0623 ,  G05B15/02 ,  G05B19/0428

    摘要： An apparatus for controlling a microfluidic circuit comprises a single microprocessor which is positioned within a single microprocessor module, the single microprocessor being used for performance in real time of: control of microfluidic components within the microfluidic circuit; accumulation of data from sensors of the microfluidic circuit; and analysis of the accumulated data in order to possibly adjust in real time at least one of the components of the microfluidic circuit based on the analysis results, thereby providing a real-time feedback. The apparatus further comprises a digital control bus for communicating digital control signals from the microprocessor module to one or more digitally-controlled microfluidic components and a sensors bus for communicating signals from one or more sensors to the microprocessor module.

    摘要翻译： 用于控制微流体电路的装置包括位于单个微处理器模块内的单个微处理器，该单个微处理器用于实时性能：控制微流体电路内的微流体组件; 从微流体电路的传感器累积数据; 并分析积累的数据，以便可能基于分析结果实时地调整微流体电路的至少一个组件，从而提供实时反馈。 该装置还包括用于将来自微处理器模块的数字控制信号传送到一个或多个数字控制的微流体部件的数字控制总线和用于将信号从一个或多个传感器传送到微处理器模块的传感器总线。