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117 条记录 (耗时 0.021 秒)

    INCREASING THE VIABILITY AND STRESS TOLERANCE OF VIABLE BIOLOGICAL MATERIAL
    53.
    发明公开
    INCREASING THE VIABILITY AND STRESS TOLERANCE OF VIABLE BIOLOGICAL MATERIAL 有权
    增LIVE生物材料的可行性抗逆性

    公开(公告)号：EP1981336A2

    公开(公告)日：2008-10-22

    申请号：EP06821517.7

    申请日：2006-11-21

    申请人： Sempre Ltd.

    发明人： HORVÁTH, András ,  PRIBENSZKY, Csaba ,  MOLNÁR, Miklós

    IPC分类号： A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0289

    摘要： The present invention relates to a method for improving viability and/or stress tolerance of viable biological material and using the said material comprising applying hydrostatic pressure to said biological material; keeping the said viable biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and using the said material for any desired purpose in accordance with any useful protocol . The usage of the said biological material incorporates any techniques, protocols that are applicable in the field of assisted reproductive techniques, biotechnical and/or biotechnological manipulations.

    NOVEL METHOD FOR CULTURING KERATINOCYTES, MELANOCYTES AND FIBROBLASTS FOR SKIN GRAFTING
    54.
    发明公开
    NOVEL METHOD FOR CULTURING KERATINOCYTES, MELANOCYTES AND FIBROBLASTS FOR SKIN GRAFTING 审中-公开
    新文化方法角质形成细胞，黑素细胞和成纤维细胞皮肤移植

    公开(公告)号：EP1768716A1

    公开(公告)日：2007-04-04

    申请号：EP05763133.5

    申请日：2005-07-11

    申请人： Kemeny, Lajos ,  Bata-Csörgö, Zsuzsa ,  Szabad, Gabor ,  Nagy, Norbert

    发明人： KEMENY, Lajos ,  BATA-CSÖRGÖ, Zsuzsa ,  SZABAD, Gábor

    IPC分类号： A61L27/60 ,  A61L27/38

    CPC分类号： A61L27/3886 ,  A61K35/12 ,  A61L27/3813 ,  A61L27/60 ,  C12N5/0626 ,  C12N5/0629 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2502/091 ,  C12N2502/094 ,  C12N2502/1323

    摘要： The present invention in general relates to the field of eukaryotic cell culture and tissue engineering, more closely to a method for the cultivation of eukaryotic cells and the use of cells cultured according to this method for the preparation of cell transplants e.g. autologous cell transplants. In particular, the invention relates to the use of keratinocyte and/or melanocyte and/or fibroblast transplants prepared according to the present invention for the treatment of various dermatological symptoms and diseases. The invention further relates to keratinocyte and/or melanocyte and/or fibroblast transplants, e.g. cell culture preparations, prepared according to the present invention. The invention concerns areas involving eukaryotic cell culture and tissue engineering, particularly fibrin-containing keratinocyte, melanocyte and fibroblast suspensions based on three constituents. The invention is particularly useful in the treatment of various conditions of skin, e.g. chronic ulcers of different origins, burn wounds, post-traumatic wound defects, defects of extensive, benign, naevoid skin changes and of scars after prior dermabrasion, vitiligo, piebaldism, etc.

    HOMO AND HETERODIMER PROTEINS OF THE ABCG FAMILY, METHODS FOR DETECTION AND SCREENING MODULATORS THEREOF
    55.
    发明公开
    HOMO AND HETERODIMER PROTEINS OF THE ABCG FAMILY, METHODS FOR DETECTION AND SCREENING MODULATORS THEREOF 审中-公开
    同性恋和异源二聚体蛋白组ABCG FAMILY方法发现和筛查调节剂

    公开(公告)号：EP1766403A2

    公开(公告)日：2007-03-28

    申请号：EP05763156.6

    申请日：2005-07-08

    申请人： Solvo Biotechnology

    发明人： CSEREPES, Judit ,  N. BARRY, Elkind ,  SZENTPETERI, Zsofia ,  SARKADI, Balazs ,  VARADI, Andras ,  KLEIN, Izabella ,  HOMOLYA, Laszlo ,  SERES, Laszlo ,  ÖZVEGY-LACZKA, Csilla

    IPC分类号： G01N33/566

    CPC分类号： G01N33/566 ,  G01N2333/70571 ,  G01N2500/00

    摘要： The invention relates to methods for screening selective modulators of half transporter proteins of the ABCG family, more closely of ABCG1 and ABCG4. In particular the invention relates to methods for determining whether a substance is a selective activator, an inhibitor or a substrate of an ABCG1 or ABCG4 homodimer or of an ABCG1/ABCG4 heterodimer protein, methods for detection of ABCG1 protein in a biological sample, methods for modulating the function of said proteins, and methods for detecting the presence of and/or quantitating ABCG1/ABCG4 heterodimer activity in a biological sample. Moreover, the invention relates to isolated ABCG1/ABCG4 heterodimer proteins and antibodies selective for ABCG1 or ABCG4. The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested to play an important role in cellular lipid/sterol regulation. ABCG1 and ABCG4 and mutants thereof have been expressed and studied by the present inventors in whole cells as well as isolated membrane preparations. A large number of compounds have been screened in this system. Co-expression of the ABCG1 and ABCG4 half transporters resulted in heterodimers.

    BIOCHEMICAL METHOD FOR THE TREATMENT AND PREVENTION OF EMULSIONS IN OIL-WELLS AND ON SURFACE EQUIPMENT
    56.
    发明公开
    BIOCHEMICAL METHOD FOR THE TREATMENT AND PREVENTION OF EMULSIONS IN OIL-WELLS AND ON SURFACE EQUIPMENT 审中-公开
    用于治疗，防止乳液在油井和设备在表面上的生物化学方法

    公开(公告)号：EP1563164A2

    公开(公告)日：2005-08-17

    申请号：EP03758372.1

    申请日：2003-10-07

    申请人： Mol Hungarian Oil and Gas Co.

    发明人： BALAZS, János ,  MECS, Imre ,  PUSKAS, Sándor ,  HLATKI, Miklos ,  KALMAN, Miklos ,  LENGYEL, Gyula ,  MOLNAR, Zsolt

    IPC分类号： E21B37/06

    CPC分类号： B09C1/10 ,  B09C1/00 ,  C09K8/524

    摘要： The present invention relates to a method for preventing the formation of oil-in-water and/or water-in-oil emulsions and/or for breaking up emulsions already formed, comprising (a) adding tensides, materials for increasing viscosity, industrial surfactants, and microorganisms capable of breaking down crude oil components or derivatives and producing at least one type of tenside, to the emulsion already formed or into the device containing the crude oil in which the formation of the emulsion to be prevented, optionally together with additives required for the reproduction of said microorganisms; (b) providing an appropriate temperature for the microorganisms after the addition of the materials listed above; (c) allowing the microorganisms to reproduce and act for a predetermined period of time; (d) checking the results of the treatment; and (e) optionally repeating steps (a) to (d) at least once more, preferably at least three more times.

    SCREENING SYSTEM BASED ON EXPRESSION OF ABCG2 HALF TRANSPORTER PROTEIN
    57.
    发明公开
    SCREENING SYSTEM BASED ON EXPRESSION OF ABCG2 HALF TRANSPORTER PROTEIN 审中-公开
    基于所述HALF-ABCG2转运蛋白筛选方法

    公开(公告)号：EP1370871A2

    公开(公告)日：2003-12-17

    申请号：EP02704990.7

    申请日：2002-03-04

    申请人： Solvo Biotechnology Inc.

    发明人： ÖZVEGY, Csilla ,  SZAKACS, Gergely ,  VARADI, András ,  NAGY, Zoltán

    IPC分类号： G01N33/68 ,  C12N5/00 ,  G01N33/574

    CPC分类号： G01N33/6872 ,  G01N2333/705

    摘要： The overexpression of an ABC half-transporter, ABCG2 (MXR/BCRP) transporter causes multidrug resistance in tumors. The present invention is based on the in vitro expression of the ABCG2 protein in insect cells as an expression system free of other, closely related, functional ABC transporters. In particular, the invention is related to a method for testing drugs for their effect on ABCG2 protein, method for the expression of active ABCG2, isolated ABCG2 homooligomers, preferably homodimers and uses thereof for testing drugs. The invention is further related to cell membrane preparations and cells, preferably insect cells comprising active ABCG2 and reagent kits for testing drugs for their effect on an ABCG2 half transporter protein. The invention is also related to a method for identifying ABCG2 activity in a biological sample, utilizing its substrate/inhibitor specificity.