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    DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin
    51.
    发明授权
    DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin 审中-公开

    公开(公告)号：EP2708225B1

    公开(公告)日：2018-12-26

    申请号：EP13184888.9

    申请日：2005-04-22

    申请人： CyDex Pharmaceuticals, Inc.

    发明人： Pipkin, James D ,  Mosher, Gerold L. ,  Hecker, Douglas B

    IPC分类号： A61K9/12 ,  A61K9/14 ,  C08B37/16

    CPC分类号： A61K47/40 ,  A61K9/0075 ,  Y10T428/2982

    摘要： An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physiochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delievered by DPI when SAE-CD is used as a carrier.

    INHALANT FORMULATION CONTAINING CYCLODEXTRIN AND CORTICOSTEROID
    52.
    发明公开
    INHALANT FORMULATION CONTAINING CYCLODEXTRIN AND CORTICOSTEROID 审中-公开
    含环糊精和皮质类固醇的配方

    公开(公告)号：EP3238708A1

    公开(公告)日：2017-11-01

    申请号：EP17161913.3

    申请日：2004-12-31

    申请人： CyDex Pharmaceuticals, Inc.

    发明人： PIPKIN, James D. ,  ZIMMERER, Rupert O. ,  THOMPSON, Diane O. ,  MOSHER, Gerold L.

    IPC分类号： A61K9/08 ,  A61K47/40 ,  A61K31/573 ,  A61K9/00

    CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/46 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  A61K31/16 ,  A61K2300/00 ,  A61K31/57 ,  A61K31/715

    摘要： An inhalable formulation comprising SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

    摘要翻译： 提供了包含SAE-CD和皮质类固醇的可吸入制剂。 该制剂适于通过用任何已知的雾化器雾化来施用于受试者。 该制剂可以包含在试剂盒中。 该制剂作为水溶液施用，然而，其可以作为干粉，即用溶液或浓缩组合物储存。 该制剂用于通过吸入施用皮质类固醇的改进的雾化系统。 存在于制剂中的SAE-CD显着增强了布地奈德的化学稳定性。 提供了通过吸入给药制剂的方法。 该制剂也可以通过常规的鼻输送装置给药。

    MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES
    53.
    发明公开
    MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES 有权
    VERFAHREN ZUR HERSTELLUNG VON CYCLODEXTRINDERIVATEN

    公开(公告)号：EP2814849A4

    公开(公告)日：2015-10-21

    申请号：EP13748804

    申请日：2013-02-14

    申请人： CYDEX PHARMACEUTICALS INC ,  MATOS JOSE R

    发明人： MATOS JOSE R ,  ANTLE VINCENT D

    IPC分类号： C08B37/16

    CPC分类号： C08B37/0012 ,  B01J2219/00164 ,  B01J2219/00166

    摘要： A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.

    摘要翻译： 提供了一种用于使取代基前体与环糊精原料反应以提供包含环糊精衍生物的原始产物和1％或更少的初始量的取代基前体的方法和设备组合物。本发明的方法提供了环糊精衍生物 实质上更短的时间和更少的副产品比使用基本相同的起始材料的先前的方法。