公开(公告)号：EP0376166A1

公开(公告)日：1990-07-04

申请号：EP89123686.1

申请日：1989-12-21

申请人： MECT CORPORATION

发明人： Yamato, Masatoshi ,  Hashigaki, Kuniko

IPC分类号： C07D221/18 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/47

CPC分类号： C07D471/04 ,  C07D221/18 ,  C07D491/04 ,  C07D495/04 ,  C07H17/02

摘要： Novel condensed quinoline system compounds such as indenoquinoline system compounds, indoloquinoline system compounds, benzothienoquinoline system compounds and benzofuranoquinoline system compounds, and a process for preparation of these compounds are provided. The present invention is also directed to salts of the above compounds. The compounds of the present invention are effective for inhibition of KB-cell growth and prolongation of life span in cancer implanted mice.

摘要翻译： 提供诸如indenoquinoline系统的化合物，indoloquinoline系统的化合物，benzothienoquinoline系统化合物和benzofuranoquinoline系统的化合物，以及用于制备合成的化合物的方法：新型稠合喹啉系化合物。 因此，本发明涉及上述化合物的盐。 本发明的化合物能有效地在植入癌症的小鼠的KB细胞生长和寿命延长的抑制。

公开(公告)号：EP0372571A2

公开(公告)日：1990-06-13

申请号：EP89122689.6

申请日：1989-12-08

申请人： MECT CORPORATION

发明人： Fujita, Shuji ,  Sugimoto, Mamoru ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： C07C69/18 ,  C07C43/15 ,  C07C309/66 ,  C07C247/08 ,  C07C233/18 ,  C07C217/46 ,  C07H15/10

CPC分类号： C07C43/178 ,  C07C69/145 ,  C07C217/46 ,  C07C233/18 ,  C07C247/08

摘要： A sphingenine and derivatives thereof herein provided are represented by the following general formulas (I) and (II):

in the formulas (I) and (II), R 1 represents a hydrogen atom, an acetyl group or a methanesulfonyl group; R 2 represents a hydrogen atom or an ethoxyethyl group; R 3 represents an azido group, an amino group, an alkylamido group, an arylamido group, an aralkylamido group or a tetracosanamido group; R 4 represents a hydrogen atom or an ethoxyethyl group; EE represents an ethoxy ethyl group; and n is an integer ranging from 1 to 22. These sphingenine and derivatives thereof are very useful as intermediates for synthesizing glycolipids and gangliosides which are effective as markers of tumours, in particular, in the preparation of ceramide parts of the glycolipids and gangliosides.

摘要翻译： 本文提供的鞘氨醇及其衍生物由式（I）和（II）中的以下通式（I）和（II）表示：，式（I）和（II）中的R 1表示氢原子，乙酰基或 甲磺酰基; R 2表示氢原子或乙氧基乙基; R 3表示叠氮基，氨基，烷基酰氨基，芳基酰氨基，芳烷基酰氨基或四聚山酰胺基; R 4表示氢原子或乙氧基乙基; EE表示乙氧基乙基; n是1至22范围内的整数。这些鞘氨醇及其衍生物作为合成作为肿瘤标记有效的糖脂和神经节苷脂的中间体非常有用，特别是制备糖脂和神经节苷脂的神经酰胺部分。

公开(公告)号：EP0269003A3

公开(公告)日：1990-05-30

申请号：EP87117092.4

申请日：1987-11-19

申请人： Toppan Printing Co., Ltd. ,  MECT CORPORATION

发明人： Abiko, Kenji c/o Tohoku Factory ,  Watanabe, Yoshio c/o Tohoku Factory ,  Anzai, Noboru c/o Tohoku Factory ,  Takahashi, Kenichi c/o Toppan Printing Co., Ltd.

IPC分类号： A61J1/06

CPC分类号： B65D41/24 ,  A61J1/065

摘要： Ampoule package in which a stem of an ampoule (1) is wrapped with a heat-shrinkable film (2), the aforesaid ampoule package being characterized in that at least a constriction (4) of the ampoule is covered with a lower portion of the heat-shrinkable film (2). According to the ampoule package of the present invention, glass fine pieces (6) of the ampoule neither go into an ampoule nor scatter around it at the time of cutting, and it is unnecessary to care about a wound and injury in cutting the ampoule.

公开(公告)号：EP0261439A3

公开(公告)日：1990-01-24

申请号：EP87112499.6

申请日：1987-08-27

申请人： MECT CORPORATION

发明人： Niwa, Ryuji ,  Katagiri, Nobuya ,  Kato, Tetsuzu ,  Shitori, Yoshiyasu ,  Horiuchi, Jiro

IPC分类号： A61K31/505

CPC分类号： A61K31/505

摘要： A medicament for curing arteriosclerosis which comprises pyrimido [2,1-b] benzothiazole derivative.

公开(公告)号：EP0296620A2

公开(公告)日：1988-12-28

申请号：EP88110126.5

申请日：1988-06-24

申请人： MECT CORPORATION

发明人： Ogasawara, Sadanori ,  Abiko, Keji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： A61K31/70

CPC分类号： C07H13/04 ,  B41M5/345 ,  Y10S514/888

摘要： A repairing agent for cells and tissues is disclosed, which agent comprises, as an active ingredient, a compound of the general formula:
wherein Z represents lithium, potassium, sodium, ammonium or an organic ammonium when n is 1, and Z represents calcium, barium or magnesium when n is 2.

摘要翻译： 对细胞和组织的修补剂盘游离缺失，其中试剂包括，作为活性成分，所述通式的化合物： worinŽdarstellt锂，钾，钠，铵或有机铵。当n为1，和Z darstellt钙，钡或镁。当n为第二

公开(公告)号：EP0281067A3

公开(公告)日：1988-12-14

申请号：EP88103065

申请日：1988-03-01

申请人： MECT CORPORATION

发明人： Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： C07H13/04 ,  C07H07/027

CPC分类号： C07H13/04

摘要： This invention relates to novel derivatives of N-acetyl-­3-fluoro-neurminic acid derivatives (I) and preparation thereof. The compound (I) can be synthesized by reacting a solution of alkyl 5-acetamido-2,6-anhydro-4,7,8,9-tetra-­O-acetyl-2,3,5-trideoxy-D-glycero-D-galacto-2-enonate with (i) an inert gas containing fluorine or (ii) acetylhypo­fluorite obtained by passing the inert gas containing fluorine through a mixture of acetic acid/acetate by passing thereinto, and then removing a solvent and apply­ing the residue through a silica gel column chromatogra­phy.

公开(公告)号：EP0281067A2

公开(公告)日：1988-09-07

申请号：EP88103065.4

申请日：1988-03-01

申请人： MECT CORPORATION

发明人： Ohrui, Hiroshi ,  Meguro, Hiroshi ,  Ido, Tatsuo

IPC分类号： C07H13/04 ,  C07H7/027

CPC分类号： C07H13/04

摘要： This invention relates to novel derivatives of N-acetyl-­3-fluoro-neurminic acid derivatives (I) and preparation thereof. The compound (I) can be synthesized by reacting a solution of alkyl 5-acetamido-2,6-anhydro-4,7,8,9-tetra-­O-acetyl-2,3,5-trideoxy-D-glycero-D-galacto-2-enonate with (i) an inert gas containing fluorine or (ii) acetylhypo­fluorite obtained by passing the inert gas containing fluorine through a mixture of acetic acid/acetate by passing thereinto, and then removing a solvent and apply­ing the residue through a silica gel column chromatogra­phy.

摘要翻译： 本发明涉及N-乙酰基-3-氟神经氨酸衍生物（I）的新衍生物及其制备方法。 化合物（I）可以通过使5-乙酰氨基-2,6-脱水-4,7,8,9-四-O-乙酰基-2,3,5-三脱氧-D-甘油醚的烷基溶液 （i）含氟的惰性气体或（ii）通过使含有氟的惰性气体通过乙酸/乙酸乙酯的混合物通过而获得的乙酰基次氟酸盐，然后除去溶剂并施加残余物 通过硅胶柱色谱法。

公开(公告)号：EP0242736A1

公开(公告)日：1987-10-28

申请号：EP87105321.1

申请日：1987-04-10

申请人： MECT CORPORATION

发明人： Ogawa, Tomoya ,  Sugimoto, Mamoru ,  Numata, Masaaki ,  Shitori, Yoshiyasu ,  Ito, Masayoshi

IPC分类号： C07H15/10

CPC分类号： C07H15/10

摘要： This invention provides a novel compound expressed by the following formula (l):
[wherein R¹ denotes a hydrogen atom or CH₃CO-, R² denotes -COOR⁴ (R⁴ denotes Na or a methyl group) or
(R⁵ denotes a hydrogen atom, -COC₆H₅ or -Si(C₆H₅)₂C(CH₃)₃ and R³ denotes
(R⁵ denotes a hydrogen atom, -COC₆H₅ or -Si(C₆H₅)₂C(CH₃)₃) when R² is -COOR⁴ (R⁴ denotes Na or a methyl group) or denotes -COOR⁴ when R² is
and a method of preparation thereof.
The above novel compounds of present invention are useful as a tumor maker, a molecular marker for cells having the ability of differential induction, or an intermediate of the synthesis thereof.

摘要翻译： 本发明提供由下式（I）表示的新化合物：其中R 1表示氢原子或CH 3 CO-，R 2表示-COOR 4（R 4表示Na或 甲基）或（R 5表示氢原子，-COC 6 H 5或-Si（C 6 H 5）2 C（CH 3）3，R 3表示CHEM（R 5表示氢原子， -COC6H5或-Si（C6H5）2C（CH3）3）当R 2为-COOR 4时（R 4表示Na或甲基）或表示-COOR 4，当R 2为 本发明的上述新化合物可用作肿瘤制造者，具有差异诱导能力的细胞的分子标记物或其合成中间体。

公开(公告)号：EP0177783A2

公开(公告)日：1986-04-16

申请号：EP85111414.0

申请日：1985-09-10

申请人： MECT Corporation

发明人： Ogasawara, Sadanori ,  Hanafusa, Takashi ,  Kariya, Katsuhide ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  C07H13/04

摘要： An expectorant capable of acting on the rheological properties of sputum and capable of directly promoting the ciliary motion. The expectorant contains N-acetyineuramin- ic acid or a pharmaceutically active salt thereof.

公开(公告)号：EP0687684A1

公开(公告)日：1995-12-20

申请号：EP94908497.4

申请日：1994-03-04

申请人： MECT CORPORATION

发明人： NUMATA, Masaaki ,  NUNOMURA, Shigeki ,  FUJITA, Shuji ,  IIDA, Masami ,  ENDO, Akira ,  ISHII, Takayuki ,  OGAWA, Tomoya ,  SUGIMOTO, Mamoru ,  OSAWA, Ryoichi ,  FUJITA, Masamichi

IPC分类号： C07H15/10 ,  C07H15/18 ,  C07H13/06 ,  C07H3/06 ,  C08B37/00 ,  A61K37/20

CPC分类号： C07H13/04 ,  C07H3/06 ,  C07H15/04 ,  C07H15/10

摘要： A Lewis-associated compound, represented by general formula (I), a process for producing the same, and an anti-inflammatory, wherein R¹ and R³ represent each hydrogen, SO₃H or CH₂COOH; R² represents hydrogen, SO₃H, CH₂COOH or N-acetyl-neutraminic acid residue; R⁴ represents hydrogen; R⁵ represents O-lower alkyl, O-lower alkenyl, O-ceramide residue, O-mannose residue, O-galactose residue or O-lactose residue; R⁶ represents acetylamine; and R⁷ and R⁸ represent each hydrogen.

摘要翻译： 由通式（I）表示的路易斯相关化合物，其制备方法和抗炎剂，其中R 1和R 3各自表示氢，SO 3 H或CH 2 COOH; R 2表示氢，SO 3 H，CH 2 COOH或N-乙酰基 - 中子二甲酸残基; R 4表示氢; R 5表示O-低级烷基，O-低级烯基，O-神经酰胺残基，O-甘露糖残基，O-半乳糖残基或O-乳糖残基; R 6表示乙酰胺; R 7和R 8分别代表氢。