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公开(公告)号：EP2694510A1
公开(公告)日：2014-02-12
申请号：EP12713963.2
申请日：2012-04-05
发明人： BÄRFACKER, Lars , SCOTT, William Johnston , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BRIEM, Hans , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： Imidazopyridazines of formula (I) a process for their production and the use thereof.
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52.发明授权ALKYNYLARYL COMPOUNDS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME 有权ALKINYLARYLVERBINDUNGEN及其盐，含药物组合物，方法及其及其用途
公开(公告)号：EP2229389B1
公开(公告)日：2011-09-14
申请号：EP08860474.9
申请日：2008-12-04
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to alkynylaryl compounds according to the general formula (I) in which A, B, D, E, Ra, R1, R3, R4, R5 and q are as defined in the claims, and salts, N-oxides, solvates and prodrugs thereof, to pharmaceutical compositions comprising said alkynylaryl compounds, to methods of preparing said alkynylaryl compounds, to intermediate compounds useful in said methods, to uses of said intermediate compounds in the preparation of said alkynylaryl compounds, as well as to uses of said alkynylaryl compounds for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth.
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公开(公告)号：EP3423446B1
公开(公告)日：2020-09-16
申请号：EP17707049.7
申请日：2017-02-28
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , GÜNTHER, Judith , STEUBER, Holger , BÖMER, Ulf , LANGE, Martin , NUBBEMEYER, Reinhard , RAY, Nicholas, Charles , SAVY, Pascal
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , A61K31/4439 , A61P29/00 , A61P35/00
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54.发明公开
公开(公告)号：EP3464266A1
公开(公告)日：2019-04-10
申请号：EP17725976.9
申请日：2017-05-29
发明人： BEDDIES, Gerald , FOSTER, Adrian , BOTHE, Ulrich , SCHMIDT, Nicole , BÖMER, Ulf , NUBBEMEYER, Reinhard , MOTTIER, Maria De Lourdes
IPC分类号： C07D401/12 , A61K31/4412 , A61K31/4439 , A61P1/00 , A61P11/00 , A61P19/00 , A61P15/00 , A61P37/00
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55.发明公开6-HYDROXYBENZOFURANYL- AND 6-ALKOXYBENZOFURANYL-SUBSTITUTED IMIDAZOPYRIDAZINES 审中-公开6-羟基苯并呋喃-2-基和6-烷氧基苯并呋喃基取代的咪唑并哒嗪
公开(公告)号：EP3237417A1
公开(公告)日：2017-11-01
申请号：EP15817825.1
申请日：2015-12-21
发明人： EIS, Knut , HARTUNG, Ingo , PETERSEN, Kirstin , LIENAU, Philip , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/5377 , A61K45/06
摘要： The present invention relates to 6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl- substituted imidazopyridazine compounds of general formula (I) in which R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的6-羟基苯并呋喃基和6-烷氧基苯并呋喃基取代的咪唑并哒嗪化合物，其中R 1和R 2如权利要求中所定义，涉及制备所述化合物的方法，涉及用于制备所述化合物的中间体化合物 ，涉及包含所述化合物的药物组合物和组合以及涉及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖和/或血管生成失调的药物组合物作为唯一药物或组合 与其他有效成分。
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56.发明公开SUBSTITUIERTE PYRIDOBENZODIAZEPINON-DERIVATE UND IHRE VERWENDUNG 审中-公开SUBSTITUIERTE PYRIDOBENZODIAZEPINON-DERIVATE和IHRE VERWENDUNG
公开(公告)号：EP3223821A1
公开(公告)日：2017-10-04
申请号：EP15797685.3
申请日：2015-11-23
发明人： SCHALL, Andreas , KLAR, Jürgen , LOBELL, Mario , SCHIROK, Hartmut , TELSER, Joachim , MÜLLER, Steffen , BROHM, Dirk , BRIEM, Hans , JÖRISSEN, Hannah , BÖTTGER, Michael , DEGENFELD VON, Georges , SCHLANGE, Thomas , BÖMER, Ulf , LINDNER, Niels , EILKEN, Hanna , HRISTODOROV, Dmitrij , WASNAIRE, Pierre , GERICKE, Kersten Matthias , BÄRFACKER, Lars
IPC分类号： A61K31/5513 , A61P27/02 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The invention relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-
b ]-[1,5]benzodiazepine-5-one-derivatives, to methods for the production thereof, use thereof alone or in combination for treating and/or for preventing diseases and use thereof in producing medicaments for treating and/or preventing diseases, especially angiogenic disorders and hyperproliferative disorders with a neovascularization component, such as opthalmologic disorders such as cancers and tumor diseases. Such treatments can be carried out as monotherapy or also in combination with other medicaments or additional therapeutic measures.摘要翻译： 本申请涉及新的（3-羟基苯基）氨基取代的吡啶并[2,3-b] [1,5]苯并二氮杂-5-酮衍生物，涉及其制备方法，其单独或组合用于治疗 和/或预防疾病及其用于制备用于治疗和/或预防疾病，尤其是新生血管形成起作用的血管生成病症和过度增殖性疾病（例如眼科疾病和癌症和肿瘤）的药物的用途。 这些治疗可以作为单一疗法或者与其他药物或其他治疗措施组合进行。
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57.发明授权N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权甲砜基团含有N-（吡啶-2-基）嘧啶-4-胺衍生物
公开(公告)号：EP2909200B1
公开(公告)日：2016-11-23
申请号：EP13777070.7
申请日：2013-10-16
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D207/44 , C07D233/88 , C07D401/12 , C07D405/14 , A61K45/06 , A61K31/506
CPC分类号： C07D401/12 , A61K31/506 , A61K45/06 , C07D207/44 , C07D233/88 , C07D405/14 , A61K2300/00
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58.发明授权5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权砜基包含5-氟-N-（吡啶-2-基）吡啶-2-胺衍生物
公开(公告)号：EP2909176B1
公开(公告)日：2016-07-20
申请号：EP13782670.7
申请日：2013-10-15
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D213/74 , C07D405/14 , A61K31/506 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D213/74 , A61K31/444 , C07D405/14
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公开(公告)号：EP2694510B1
公开(公告)日：2015-10-14
申请号：EP12713963.2
申请日：2012-04-05
发明人： BÄRFACKER, Lars , SCOTT, William Johnston , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BRIEM, Hans , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
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公开(公告)号：EP2852596A1
公开(公告)日：2015-04-01
申请号：EP13725935.4
申请日：2013-05-17
发明人： KETTSCHAU, Georg , PÜHLER, Florian , EIS, Knut , KLAR, Ulrich , KOSEMUND, Dirk , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , BÖMER, Ulf , WORTMANN, Lars , GRAHAM, Keith , WENGNER, Antje Margret
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and /or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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