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公开(公告)号：EP1036086A1
公开(公告)日：2000-09-20
申请号：EP98950774.4
申请日：1998-09-30
发明人： RUBEN, Steven, M. , NI, Jian
CPC分类号： C12N9/6475 , C07K14/4747
摘要： The present invention relates to a novel Caspase-14 protein (also called ERICE) which is a novel effector of apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human Caspase-14 protein. Caspase-14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Caspase-14 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
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公开(公告)号：EP1032838A1
公开(公告)日：2000-09-06
申请号：EP98956533.8
申请日：1998-11-04
发明人： FENG, Ping , CARTER, Kenneth, C. , ENDRESS, Gregory, A. , ROSEN, Craig, A. , RUBEN, Steven, M. , JANAT, Fouad , NI, Jian , WEI, Ying-Fei , MOORE, Paul, A. , SOPPET, Daniel, R. , KYAW, Hla , LaFLEUR, David, W. , OLSEN, Henrik, S. , SHI, Yanggu , EBNER, Reinhard
IPC分类号： G01N33/68 , G01N33/53 , C07K16/00 , C12N15/11 , C12N15/12 , C12N15/00 , C12N15/63 , A61K38/17 , A61K38/16 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1015477A1
公开(公告)日：2000-07-05
申请号：EP98926105.2
申请日：1998-05-28
发明人： RUBEN, Steven, M. , ROSEN, Craig, A. , CARTER, Kenneth, C. , DILLON, Patrick, J. , ENDRESS, Gregory, A. , YU, Guo-Liang , NI, Jian , FENG, Ping
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to 32 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1007663A2
公开(公告)日：2000-06-14
申请号：EP98903557.1
申请日：1998-01-21
发明人： NI, Jian , ROSEN, Craig, A. , GENTZ, Reiner, L. , FENG, Ping , KRISSANSEN, Geoffery, W. , SU, Jeffrey, Y.
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1005551A2
公开(公告)日：2000-06-07
申请号：EP98903730.4
申请日：1998-01-27
发明人： GENTZ, Reiner, L. , HSU, Tsu-An , NI, Jian , ROSEN, Craig, A.
IPC分类号： C12N15/15 , C07K14/81 , C12N5/10 , C07K16/38 , C12N15/11 , A61K38/57 , A61K39/395 , A61K31/705
CPC分类号： C07K14/8114 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a novel TFPI-3 protein which is a member of the tissue factor protease inhibitor family. In particular, isolated nucleic acid molecules are provided encoding human TFPI-3 proteins. TFPI-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TFPI-3 activity. Also provided are diagnostic methods for detecting hemostasis system-related disorders and therapeutic methods for treating hemostatis system-related disorders.
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公开(公告)号：EP0988371A1
公开(公告)日：2000-03-29
申请号：EP98926471.8
申请日：1998-06-10
发明人： NI, Jian , YU, Guo-Liang , FAN, Ping , GENTZ, Reiner, L.
IPC分类号： C12N1/21
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/7151 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
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公开(公告)号：EP0972022A2
公开(公告)日：2000-01-19
申请号：EP98902623.2
申请日：1998-01-21
发明人： NI, Jian , GENTZ, Reiner, L. , ROSEN, Craig, A.
IPC分类号： C12N15/12 , C12N15/85 , C12N5/10 , C07K14/705 , C07K16/28 , C12Q1/68 , A61K31/70 , A61K38/17 , A61K48/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
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公开(公告)号：EP0961831A1
公开(公告)日：1999-12-08
申请号：EP96928886.0
申请日：1996-08-16
发明人： YU, Guo-Liang , NI, Jian , ROSEN, Craig, A.
IPC分类号： C12N15 , A61K39 , A61P35 , A61P37 , C07H21 , C07K1 , C07K14 , C07K16 , C12N1 , C12P21 , C12Q1 , A61K38 , C12R1
CPC分类号： C07K14/5255 , A61K38/00 , C07K14/52
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译： 本发明涉及肿瘤坏死因子（TNF）家族细胞因子的新成员。 具体而言，提供了编码内因子α蛋白的分离的核酸分子。 还提供了内因子α多肽，如载体，宿主细胞和用于生产它们的重组方法。 还提供了关于TNF家族相关疾病的诊断和治疗方法。
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公开(公告)号：EP0961782A1
公开(公告)日：1999-12-08
申请号：EP96942776.0
申请日：1996-10-30
发明人： NI, Jian , ROSEN, Craig, A. , GENTZ, Reiner, L. , LYN, Sally, Doreen, Patricia , HURLE, Mark, Robert
CPC分类号： C07K14/7151 , A61K38/00
摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
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公开(公告)号：EP0960198A1
公开(公告)日：1999-12-01
申请号：EP96927373.0
申请日：1996-08-09
发明人： NI, Jian , GENTZ, Reiner, L. , DILLON, Patrick, J.
摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.
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