公开(公告)号：EP1735308B1

公开(公告)日：2008-09-10

申请号：EP05725295.9

申请日：2005-03-09

申请人： Corcept Therapeutics, Inc.

发明人： CLARK, Robin, D. ,  RAY, Nicholas, C. ,  BLANEY, Paul, M. ,  HURLEY, Christopher A. ,  WILLIAMS, Karen

IPC分类号： C07D471/04 ,  C07D498/04 ,  A61K31/437 ,  A61P25/24

CPC分类号： C07D471/04

摘要： The present invention provides a novel class of fused ring azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.

公开(公告)号：EP1581234A4

公开(公告)日：2007-09-12

申请号：EP03768706

申请日：2003-11-05

申请人： CORCEPT THERAPEUTICS INC

发明人： BELANOFF JOSEPH K

IPC分类号： A61K31/00 ,  A61K31/56 ,  A61K31/573 ,  A61K31/59 ,  A61P25/06

CPC分类号： A61K31/59 ,  A61K31/00 ,  A61K31/56 ,  A61K31/573

公开(公告)号：EP1761497A2

公开(公告)日：2007-03-14

申请号：EP05711316.9

申请日：2005-01-10

申请人： Corcept Therapeutics, Inc.

发明人： CLARK, Robin D. ,  RAY, Nicholas C. ,  BLANEY, Paul ,  HURLEY, Christopher ,  WILLIAMS, Karen ,  HUNT, Hazel ,  CLARK, David

IPC分类号： C07D217/04 ,  C07D217/06 ,  C07D217/08 ,  C07D401/12 ,  C07D405/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D513/06 ,  A61K31/4725 ,  A61K31/472 ,  A61P5/44

CPC分类号： C07D217/04 ,  C07D217/02 ,  C07D217/06 ,  C07D217/08 ,  C07D401/10 ,  C07D401/12 ,  C07D405/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D491/10 ,  C07D513/04 ,  C07D513/06

摘要： The present invention provides a novel class of azadecalin compounds of formula (I) and methods of using the compounds as glucocorticoid receptor modulators.

公开(公告)号：EP1648469A2

公开(公告)日：2006-04-26

申请号：EP04779017.5

申请日：2004-07-23

申请人： Corcept Therapeutics, Inc.

发明人： BELANOFF, Joseph K.

IPC分类号： A61K31/56

CPC分类号： A61K31/56 ,  A61K31/00 ,  A61K31/05 ,  A61K31/567 ,  A61K31/568 ,  A61K31/58

摘要： The invention provides a method of ameliorating the symptoms of catatonia in a patient who is in need of treatment for catatonia. The method comprises administration of a therapeutically effective amount of a glucocorticoid receptor antagonist to the patient.

公开(公告)号：EP1567167A2

公开(公告)日：2005-08-31

申请号：EP03768714.2

申请日：2003-11-05

申请人： Corcept Therapeutics, Inc.

发明人： BELANOFF, Joseph, K.

IPC分类号： A61K31/56 ,  A61K31/05

CPC分类号： A61K31/59 ,  A61K31/00 ,  A61K31/56 ,  A61K31/573

摘要： This invention relates to the discovery that agents capable of inhibiting the biological action of the glucocorticoid receptor can be used in methods for treating gastroesophageal reflux disease in a subject.

公开(公告)号：EP1408981A4

公开(公告)日：2005-06-08

申请号：EP02750269

申请日：2002-07-22

申请人： CORCEPT THERAPEUTICS INC

发明人： BELANOFF JOSEPH K ,  SCHATZBERG ALAN F

IPC分类号： A61K45/00 ,  A61K31/00 ,  A61K31/5513 ,  A61K31/567 ,  A61K31/569 ,  A61K31/575 ,  A61K45/06 ,  A61P3/04 ,  C07J43/00 ,  A61K31/56

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/5513 ,  A61K31/567 ,  A61K31/575 ,  A61K2300/00

摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptors can be used in methods for preventing antipsychotic-induced weight gain. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for preventing AP-induced weight gain in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

公开(公告)号：EP1242094A1

公开(公告)日：2002-09-25

申请号：EP00982226.3

申请日：2000-11-21

申请人： Corcept Therapeutics Inc.

发明人： SCHATZBERG, Alan, F. ,  BELANOFF, Joseph, K.

IPC分类号： A61K31/57

CPC分类号： A61K31/568 ,  A61K31/00 ,  A61K31/56 ,  A61K31/567

摘要： This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for treating mild cognitive impairment. Mifepristone, a potent specific glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for treating mild cognitive impairment in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

公开(公告)号：EP3277281B1

公开(公告)日：2022-01-05

申请号：EP16774094.3

申请日：2016-03-30

发明人： MORAITIS, Andreas G. ,  COHAN, Pejman ,  BELANOFF, Joseph K.

IPC分类号： A61K31/496 ,  A61K31/5377 ,  A61K31/5375

公开(公告)号：EP3592358A1

公开(公告)日：2020-01-15

申请号：EP18763240.1

申请日：2018-03-08

申请人： Corcept Therapeutics, Inc.

发明人： MORAITIS, Andreas G.

IPC分类号： A61K31/57 ,  A61K51/08

公开(公告)号：EP3335043A1

公开(公告)日：2018-06-20

申请号：EP16836011.3

申请日：2016-08-12

申请人： Corcept Therapeutics, Inc.

发明人： MORAITIS, Andreas G.

IPC分类号： G01N33/50 ,  A61K31/575 ,  C07D217/08

CPC分类号： G01N33/74 ,  A61K31/4745 ,  A61K31/567 ,  A61K31/573 ,  G01N2333/695 ,  G01N2800/048

摘要： This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.