公开(公告)号：EP2995952A1

公开(公告)日：2016-03-16

申请号：EP15181977.8

申请日：2015-08-21

申请人： Fujifilm Corporation

发明人： Nakamura, Kazuhiro ,  Kasagi, Noriyuki ,  Chiku, Hiroyuki ,  Nakamura, Kentaro

IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/58 ,  G01N33/74

CPC分类号： G01N33/74 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2333/695

摘要： The present invention provides a reagent kit which is used for measuring a test substance in a biological sample and can improve measurement sensitivity of the test substance; measurement kit; and a method of measuring the test substance. Provided is a reagent kit which is used for measuring the above-described test substance in the biological sample and contains first particles which are modified by a first binding substance having specific binding properties with respect to the test substance and have a label, and a compound which has at least one amino group having a positive charge.

摘要翻译： 本发明提供一种试剂盒，用于测定生物样品中的检测物质，能够提高检测物质的测定灵敏度; 测量套件; 以及测定被检物质的方法。 提供了一种试剂盒，其用于测量生物样品中的上述测试物质，并且包含由相对于测试物质具有特异性结合特性的第一结合物修饰并具有标记的第一颗粒和化合物 其具有至少一个具有正电荷的氨基。

公开(公告)号：EP1784414A4

公开(公告)日：2009-10-21

申请号：EP05808430

申请日：2005-08-12

申请人： UNIV CALIFORNIA

发明人： LICINIO JULIO ,  WONG MA-LI ,  IRIZARRY K J L ,  IRIZARRY K M

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P19/34

CPC分类号： G01N33/74 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N2333/695 ,  G01N2333/72 ,  G01N2800/30 ,  G01N2800/52

公开(公告)号：EP2799549A4

公开(公告)日：2015-08-12

申请号：EP12861582

申请日：2012-12-20

申请人： SYSMEX CORP

发明人： ITOH KATSUNORI ,  KABATA HIROYUKI

IPC分类号： C12N15/115 ,  C07K14/695 ,  C12Q1/68 ,  G01N21/78 ,  G01N33/53

CPC分类号： C12N15/115 ,  C07K14/575 ,  C07K14/695 ,  C12N2310/16 ,  C12Q1/6811 ,  C12Q2525/117 ,  C12Q2525/205 ,  G01N21/6428 ,  G01N21/76 ,  G01N21/78 ,  G01N33/74 ,  G01N2333/695

公开(公告)号：EP2553459A1

公开(公告)日：2013-02-06

申请号：EP11712659.9

申请日：2011-03-31

申请人： Cambridge Enterprise Ltd.

发明人： BAHN, Sabine ,  GUEST, Paul ,  HARRIS, Laura ,  LEVIN, Yishai ,  KRISHNAMURTHY, Divya

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6896 ,  G01N2333/475 ,  G01N2333/575 ,  G01N2333/5756 ,  G01N2333/695 ,  G01N2333/775 ,  G01N2333/96441 ,  G01N2800/302 ,  G01N2800/52

摘要： The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder.

公开(公告)号：EP2615103B1

公开(公告)日：2015-04-22

申请号：EP13150698.2

申请日：2013-01-09

申请人： SYSMEX CORPORATION

发明人： Tsuruoka, Rena

IPC分类号： C07K1/22 ,  G01N33/74

CPC分类号： G01N33/74 ,  G01N2333/695

摘要： A method for detecting adrenocorticotropic hormone comprising: bringing a liquid sample containing adrenocorticotropic hormone into contact with gelled casein to adsorb adrenocorticotropic hormone to the gelled casein; and detecting the adrenocorticotropic hormone adsorbed to the gelled casein is disclosed. An adsorbent of adrenocorticotropic hormone comprising gelled casein is also disclosed.

公开(公告)号：EP2615103A1

公开(公告)日：2013-07-17

申请号：EP13150698.2

申请日：2013-01-09

申请人： SYSMEX CORPORATION

发明人： Tsuruoka, Rena

IPC分类号： C07K1/22 ,  G01N33/74

CPC分类号： G01N33/74 ,  G01N2333/695

摘要： A method for detecting adrenocorticotropic hormone comprising: bringing a liquid sample containing adrenocorticotropic hormone into contact with gelled casein to adsorb adrenocorticotropic hormone to the gelled casein; and detecting the adrenocorticotropic hormone adsorbed to the gelled casein is disclosed. An adsorbent of adrenocorticotropic hormone comprising gelled casein is also disclosed.

摘要翻译： 一种检测促肾上腺皮质激素的方法，包括：使含有促肾上腺皮质激素的液体样品与凝胶酪蛋白接触，将促肾上腺皮质激素吸附到凝胶酪蛋白上; 并且公开了检测吸附在胶凝酪蛋白上的促肾上腺皮质激素。 还公开了包含凝胶酪蛋白的促肾上腺皮质激素吸附剂。

公开(公告)号：EP2553459B1

公开(公告)日：2015-03-04

申请号：EP11712659.9

申请日：2011-03-31

申请人： Cambridge Enterprise Ltd.

发明人： BAHN, Sabine ,  GUEST, Paul ,  HARRIS, Laura ,  LEVIN, Yishai ,  KRISHNAMURTHY, Divya

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6896 ,  G01N2333/475 ,  G01N2333/575 ,  G01N2333/5756 ,  G01N2333/695 ,  G01N2333/775 ,  G01N2333/96441 ,  G01N2800/302 ,  G01N2800/52

公开(公告)号：EP1784414A2

公开(公告)日：2007-05-16

申请号：EP05808430.2

申请日：2005-08-12

申请人： The Regents of the University of California

发明人： LICINIO, Julio ,  WONG, Ma-Li ,  IRIZARRY, K.J.L., UCLA Neuropsychiatric Inst. ,  IRIZARRY, K.M., UCLA Neuropsychiatric Inst.

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12P19/34

CPC分类号： G01N33/74 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N2333/695 ,  G01N2333/72 ,  G01N2800/30 ,  G01N2800/52

摘要： The invention provides genetic means, including compositions (e.g., kits) and methods, to predict the efficacy of a treatment in depression and anxiety and to predict a patient's response to a particular a specific medication or treatment. The invention provides methods for diagnosing the presence of a psychiatric disorder or determining the outcome of a treatment for a psychiatric disorder. The invention provides methods for methods for diagnosing the presence of a psychiatric disorder in an individual by determining what corticotropin-releasing hormone receptor 1 (CRHR1) protein or transcript isoforms are expressed in an individual. The invention provides methods for diagnosing the presence of a psychiatric disorder in an individual by determining what protein or transcript isoforms are expressed in an individual wherein the protein is involved in the hypothalamic-pituitary-adrenal (HPA) axis pathway.

公开(公告)号：EP0935655A1

公开(公告)日：1999-08-18

申请号：EP97939799.0

申请日：1997-09-04

申请人： OREGON HEALTH SCIENCES UNIVERSITY ,  Cone, Roger D. ,  Fan, Wei ,  Boston, Bruce A. ,  Kesterton, Robert A. ,  Lu, Dongsi ,  Chen, Wenbiao

发明人： CONE, Roger, D. ,  FAN, Wei ,  BOSTON, Bruce, A. ,  KESTERTON, Robert, A. ,  LU, Dongsi ,  CHEN, Wenbiao

IPC分类号： C12N15 ,  A61K38 ,  A61K45 ,  A61P3 ,  A61P43 ,  C07K7 ,  C07K14 ,  C12N5 ,  C12P21 ,  C12Q1 ,  G01N33

CPC分类号： C07K14/72 ,  A61K38/00 ,  C07K7/56 ,  C07K14/723 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q1/6897 ,  C12Q2600/136 ,  G01N33/74 ,  G01N2333/68 ,  G01N2333/695 ,  G01N2333/72 ,  G01N2333/726 ,  G01N2500/00

摘要： The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, and mammalian cells into which said recombinant expression constructs have been introduced that express functional mammalian melanocortin receptors. The invention provides a panel of such transformed mammalian cells expressing melanocortin receptors for screening compounds for receptor agonist and antagonist activity. The invention also provides methods for using such panels of melanocortin receptor-expressing mammalian cells to specifically detect and identify agonists and antagonists for each melanocortin receptor, as well as patterns of agonist and antagonist activity of said compounds for the class of melanocortin receptors. Such screening methods provide a means for identifying compounds with patterns of melanocortin agonist and antagonist activity which is associated with the capacity to influence or modify metabolism and behavior, particularly feeding behavior.

公开(公告)号：EP3335043A1

公开(公告)日：2018-06-20

申请号：EP16836011.3

申请日：2016-08-12

申请人： Corcept Therapeutics, Inc.

发明人： MORAITIS, Andreas G.

IPC分类号： G01N33/50 ,  A61K31/575 ,  C07D217/08

CPC分类号： G01N33/74 ,  A61K31/4745 ,  A61K31/567 ,  A61K31/573 ,  G01N2333/695 ,  G01N2800/048

摘要： This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome. Current practice for differentially diagnosing ectopic ACTH syndrome and Cushing's Disease measures relative ACTH concentrations from the inferior petrosal venous sinus compared to fluid obtained from a periphery venous sample. This is performed before and after administration of exogenous corticotropin releasing factor, or after administration of metyrapone. This invention uses glucocorticoid receptor antagonists to induce release of endogenous CRH which stimulates ACTH to increase in patients with ectopic ACTH syndrome but not in those with Cushing's Disease.