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公开(公告)号：EP0752889B1
公开(公告)日：2002-06-26
申请号：EP95913223.4
申请日：1995-03-27
发明人： KLAVENESS, Jo , BERG, Arne , JACOBSEN, Trond Vegard , RONGVED, Pal , EGE, Thorfinn , KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd. , YACHI, Kiyoto, Daiichi Pharmaceutical Co., Ltd.
CPC分类号： A61K49/227 , A61K49/0466 , A61K49/1812
摘要： The invention provides a diagnostic composition for administration to human or animal subjects the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.
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公开(公告)号：EP0779821B1
公开(公告)日：2002-03-27
申请号：EP95930653.1
申请日：1995-09-06
申请人： NYCOMED IMAGING AS
发明人： KLAVENESS, Jo , RONGVED, Pal , STRANDE, Per
CPC分类号： A61B8/481 , A61F2210/0004 , A61K49/0002 , A61K49/22 , A61L15/62 , A61L27/58
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公开(公告)号：EP1181571A1
公开(公告)日：2002-02-27
申请号：EP00935304.6
申请日：2000-05-22
申请人： NYCOMED IMAGING AS
发明人： BJORNERUD, Atle , BRILEY-SAEBO, Karen , KNOPP, Michael, Vinzenz , MCGILL, Stephen , SCHOENBERG, Stefan, Oswald
IPC分类号： G01R33/563
CPC分类号： G01R33/563 , G01R33/281
摘要： A method of magnetic resonance imaging of the kidney in a vascularised human or non human body wherein a blood pool MR contrast agent, preferably a paramagnetic contrast agent, is administered as a bolus into the vasculature of said body and images of said kidney are generated using imaging sequences and timing to permit both visualisation and gradation of renal artery stenosis and quantification of renal perfusion, and, optionally, values indicative of renal artery stenosis grade and renal perfusion are generated from said images. Preferably, T2*-weighted images are generated during the first pass T1- weighted images are generated. after the concentration of contrast agent throughout the blood has become substantially uniform.
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公开(公告)号：EP0871896B1
公开(公告)日：2002-01-30
申请号：EP96929434.7
申请日：1996-09-06
申请人： Nycomed Imaging AS
IPC分类号： G01R33/62
CPC分类号： A61K49/20 , G01R33/281 , G01R33/62
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55.发明授权
公开(公告)号：EP0929465B1
公开(公告)日：2001-11-07
申请号：EP97937731.4
申请日：1997-08-27
申请人： NYCOMED IMAGING AS
CPC分类号： A61K49/223 , A61B2090/3925 , A61J1/06 , A61J1/10 , A61J1/14 , A61M5/007 , A61M2207/00 , B65D51/005 , B65D51/30 , Y10T428/1352 , Y10T428/1376 , Y10T428/1386 , Y10T428/214
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公开(公告)号：EP0923537B1
公开(公告)日：2001-10-31
申请号：EP97937743.9
申请日：1997-08-29
申请人： NYCOMED IMAGING AS
IPC分类号： C07C231/08
CPC分类号： C07C231/08
摘要： The invention provides a process for the preparation of an N-alkyl-acylamino-phenyl-carboxylic acid or carboxylic acid derivative by liquid phase acylation and subsequent N-alkylation of a corresponding amino-phenyl-carboxylic acid (or carboxylic acid derivative), the improvement comprising the addition of an alkylating agent to a solution containing the reaction products of said acylation, to effect said N-alkylation.
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公开(公告)号：EP1123116A2
公开(公告)日：2001-08-16
申请号：EP99950946.6
申请日：1999-10-22
申请人： NYCOMED IMAGING AS
发明人： KELLAR, Kenneth
IPC分类号： A61K49/00
CPC分类号： A61K49/06
摘要： The invention relates to the use as a contrast agent in MR imaging of a physiologically tolerable lanthanide compound or salt thereof having first and second oxidation states which differ in relaxivity by a factor of at least 5, and which is convertible in vivo from said first to said second oxidation state whereby contrast is enhanced in a body region in which conversion to said second state does or does not occur.
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公开(公告)号：EP1122185A2
公开(公告)日：2001-08-08
申请号：EP01101704.3
申请日：2001-01-25
申请人： NYCOMED IMAGING AS
IPC分类号： B65D51/00
CPC分类号： B65D51/002 , B65D55/024
摘要： A package (10) comprises a container (20), a closure member (40) removably inserted into the mouth of the container, and a cap (50). The cap has a cover member (52) which overlies the closure and has a region (66) which is removable to expose the upper surface of the closure to allow piercing thereof by a needle or the like. The removable region is provided with a pull-ring (68) protected from accidental operation by a protective portion (60) projecting upwardly from the edge of the cover member (52). The protective portion is formed separately from the rest of the cap and is attached thereto.
摘要翻译： 包装（10）包括容器（20），可拆卸地插入容器的口中的封闭构件（40）和盖（50）。 帽具有盖构件（52），该盖构件覆盖在封闭件上并且具有可移除以暴露封闭件的上表面的区域（66），以允许通过针或类似物刺穿它。 可移除区域设置有通过从盖构件（52）的边缘向上突出的保护部分（60）而防止意外操作的拉环（68）。 保护部分与盖的其余部分分开形成并附接到其上。
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公开(公告)号：EP1118009A1
公开(公告)日：2001-07-25
申请号：EP99947646.8
申请日：1999-09-21
申请人： NYCOMED IMAGING AS
IPC分类号： G01R33/28
CPC分类号： G01R33/5601
摘要： The invention provides a method of magnetic resonance imaging of regional blood oxygenation which comprises administering into the vasculature of a vascularised human or non-human animal subject a T2 blood pool contrast agent, detecting a magnetic resonance signal from at least part of the vasculature of said subject into which said contrast agent distributes, and manipulating said signal to generate an indication of the partial pressure of oxygen (pO2) in at least part of said vasculature.
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公开(公告)号：EP1089662A1
公开(公告)日：2001-04-11
申请号：EP99926652.1
申请日：1999-06-23
申请人： NYCOMED IMAGING AS
CPC分类号： A61B8/0883 , A61B8/06 , A61B8/0891 , A61B8/481 , A61K49/223
摘要： A method of assessing relative rates of blood flow in the coronary arteries which involves observing one or more flow parameters in respect of contrast agent-containing blood flowing in at least one coronary artery of a subject, by generating a sequence of ultrasound images of the heart in a plane at least substantially perpendicular to the cardiac axis. Ultrasound imaging techniques which may be employed include power Doppler imaging and second harmonic B-mode or power Doppler imaging.
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