公开(公告)号：EP3568153A1

公开(公告)日：2019-11-20

申请号：EP18738758.4

申请日：2018-01-12

Applicant: Tobishi Pharmaceutical Co., Ltd. ,  Tokai University Educational System

Inventor： MASUDA, Haruchika ,  ASAHARA, Takayuki ,  SENGA, Hirobumi

IPC: A61K38/48 ,  A61P1/18 ,  A61P7/00 ,  A61P11/00 ,  A61P31/04

公开(公告)号：EP1108434B1

公开(公告)日：2014-05-14

申请号：EP99938581.8

申请日：1999-08-23

Applicant: Kurokawa, Kiyoshi ,  Miyata, Toshio ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM

Inventor： MIYATA, Toshio

IPC: A61K45/00 ,  A61K31/155 ,  A61K31/15 ,  A61K33/44 ,  A61K31/44 ,  A61K31/195 ,  A61K38/38 ,  A61M1/28

CPC classification number: A61K31/203 ,  A61K31/155 ,  A61K31/4965 ,  A61K33/00 ,  A61M1/287 ,  Y10S514/832 ,  Y10S514/866 ,  A61K2300/00

公开(公告)号：EP2662453A2

公开(公告)日：2013-11-13

申请号：EP13003496.0

申请日：2008-07-31

Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Tokyo Metropolitan Institute of Medical Science ,  Renascience CO., LTD. ,  Medical and Biological Laboratories Co., Ltd.

Inventor： Itokawa, Masanari ,  Miyata, Toshio ,  Arai, Makoto

IPC: C12Q1/68 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/437 ,  A61K31/4415 ,  A61K31/4439 ,  A61K45/00 ,  A61P25/18 ,  C12N15/09 ,  G01N30/88 ,  G01N33/15

CPC classification number: C12Q1/527 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/437 ,  A61K31/4415 ,  A61K31/4439 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/988

Abstract: The present invention relates to a method for diagnosing schizophrenia comprising measuring at least one parameter in a subject, the parameter being selected from the group consisting of (1) a genetic abnormality of glyoxalase I gene, (2) the expression level or activity of glyoxalase I in a biological sample, (3) the amount of a carbonyl-modified protein that is a protein modified with the carbonyl-compound, preferably pentosidine, in a biological sample, and (4) the amount of pyridoxal in a biological sample. The present further relates to a primer, a probe and a reagent for use in said method, as well as an AGE-reader and its use for measuring the amount of carbonyl-modified proteins.

Abstract translation: 本发明涉及一种诊断精神分裂症的方法，包括测量受试者中的至少一个参数，所述参数选自（1）乙二醛酶I基因的遗传异常，（2）乙醛酸酶的表达水平或活性 I在生物样品中，（3）在生物样品中用羰基化合物（优选戊糖）修饰的蛋白质的羰基修饰蛋白质的量，和（4）生物样品中吡哆醛的量。 本发明还涉及用于所述方法的底漆，探针和试剂，以及AGE读数器及其用于测量羰基修饰的蛋白质的量的用途。

公开(公告)号：EP2554660A1

公开(公告)日：2013-02-06

申请号：EP11762825.5

申请日：2011-03-29

Applicant: Tokai University Educational System

Inventor： SAKAI, Daisuke ,  MOCHIDA, Joji ,  ANDO, Kiyoshi ,  NAKAMURA, Yoshihiko

IPC: C12N5/077 ,  A61K35/28 ,  A61K38/00 ,  A61P19/00 ,  C12N5/0775

CPC classification number: C12N5/0654 ,  A61K35/12 ,  C12N5/0655 ,  C12N5/0668 ,  C12N2501/17 ,  C12N2502/1394 ,  C12N2502/99

Abstract: The purpose of the present invention is to provide intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. The present invention provides an intervertebral disk nucleus pulposus cell characterized by being isolated from the intervertebral disk nucleus pulposus of a vertebrate and being positive for at least one surface marker from among Tie2 and GD2. That is, the present invention provides an intervertebral disk nucleus pulposus stem cell characterized by being at least Tie2-positive for the surface marker and possessing self-renewal ability as well as multipotency capable of differentiating into adipocytes, osteocytes, chondrocytes and neurons. The present invention also provides an intervertebral disk nucleus pulposus progenitor cell characterized by being at least Tie2-negative and GD2-positive for the surface marker and capable of differentiating into any of adipocytes, osteocytes, chondrocytes and neurons.

Abstract translation: 本发明的目的是提供一种椎间盘髓核干细胞或祖细胞也可以用于治疗椎间盘病症。 本发明提供了由来自脊椎动物的椎间盘髓核中分离并从Tie2的和GD2中用于至少一个表面标记是正的特征的椎间盘髓核细胞。 即，本发明提供了对通过至少是Tie2的正面为表面标志物和特点波塞唱能够分化成脂肪细胞，骨细胞，软骨细胞和神经细胞的自我更新能力，以及多能椎间盘髓核干细胞。 本发明因此提供了关于通过至少是特征的椎间盘髓核祖细胞Tie2的负和GD2阳性的表面标记物和能分化成任何的脂肪细胞，骨细胞，软骨细胞和神经元。

公开(公告)号：EP2446928A1

公开(公告)日：2012-05-02

申请号：EP10815423.8

申请日：2010-09-09

Applicant: Tokai University Educational System ,  Comet Corporation

Inventor： ITOH, Johbu

IPC: A61N5/06

CPC classification number: A61N5/0601 ,  A61B18/18 ,  A61B2018/1807 ,  A61N5/0613 ,  A61N2005/0654 ,  A61N2005/0661

Abstract: It is an object of the present invention to provide a method and an apparatus capable of selectively damaging and killing tumor cells. In one aspect of the present invention, there is provided a method for selectively damaging and killing tumor cells comprising a step of irradiating tumor cells with a pulse light having continuous emission spectra ranging at least from 230 to 270 nm (UV pulse flash), outside a living body of a human or a living body of a non-human animal or in a living body of a non-human animal. The UV pulse flash, preferably, has an accumulated irradiation amount per unit area that is achieved at a distance of 8 cm from a light source having an integrated output of, for example, 90, 180-7100 or 14200 J. In other words, the UV pulse flash, preferably, has an accumulated irradiation amount per unit area of, for example, 6, 12-480 or 960 J/cm 2 in terms of an energy originated from a wavelength of UVC. The step of irradiating with the UV pulse flash is preferably carried out, for example, within 1 minute. The UV pulse flash is preferably emitted from a xenon flash lamp. As another aspect of the present invention, there is provided an apparatus for treating tumor tissues comprising a light source of the UV pulse flash.

Abstract translation: 它是本发明的一个目的是提供一种方法和一种能够选择性地破坏和杀死肿瘤细胞的装置。 在本发明的一个方面，提供了一种方法，用于选择性破坏和杀死肿瘤细胞，其包括照射肿瘤细胞与具有连续发射光谱范围的至少230至270纳米（UV脉冲闪光）的脉冲光的步骤中，外 人类的活体或非人类动物的或在非人类动物的生物体内的生物体。 的UV脉冲闪光灯，优选地，具有对没有由具有在积分输出，例如，90，180-7100或14200 J.换句话说光源取得在8厘米的距离每单位面积的累积照射量， 紫外脉冲闪光灯，优选地，具有每单位面积累积照射量，例如，6，12至480或960焦耳/ cm 2的在能量方面源于UVC的波长。 用UV脉冲闪光照射的步骤优选进行，例如，分钟内的第一 的UV脉冲闪光灯优选由氙闪光灯发射的。 作为本发明的另一个方面，提供了到用于治疗肿瘤组织，包括紫外脉冲闪光的光源。

公开(公告)号：EP2058353B1

公开(公告)日：2012-02-15

申请号：EP07806534.9

申请日：2007-08-31

Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Tokyo Medical and Dental University

Inventor： NAGASE, Yu ,  SHIMOYAMADA, Naoya ,  IWASAKI, Yasuhiko ,  ISHIHARA, Kazuhiko

IPC: C08G69/26 ,  A61L27/00 ,  A61L33/00 ,  C07F9/09 ,  C08G18/32 ,  C08G73/10

CPC classification number: C08G73/1046 ,  C07F9/091 ,  C08G18/10 ,  C08G18/3206 ,  C08G69/26 ,  C08G73/105 ,  C08G18/4854 ,  C08G18/3889

Abstract: Disclosed is a highly polymerizable diamine compound containing a phosphorylcholine group. Also disclosed is a high molecular weight polymer which uses the phosphorylcholine group-containing highly polymerizable diamine compound as one of the starting raw materials and is improved in mechanical strength, water resistance and heat resistance, while maintaining excellent biocompatibility and workability as an MPC polymer. Further disclosed is a method for producing such a high molecular weight polymer. Specifically disclosed is a specific diamine compound represented by the formula (I) below and containing a phosphorylcholine group. Also specifically disclosed is a polymer represented by the formula (II) below and having a number average molecular weight of not less than 5,000, while containing at least 1% by mole of a specific structural unit having a phosphorylcholine group. Further specifically disclosed is a method for producing such a polymer by using the diamine compound as one of the raw materials.

公开(公告)号：EP2402017A1

公开(公告)日：2012-01-04

申请号：EP10746321.8

申请日：2010-02-26

Applicant: The Doshisha ,  Tokai University Educational System

Inventor： KANO Koji ,  KITAGISHI Hiroaki ,  NEGI Shigeru ,  KIRIYAMA Akiko ,  HONBO Akino ,  KAWAGUCHI Akira ,  TSUKADA Hideo

IPC: A61K31/714 ,  A61K31/724 ,  A61K47/40 ,  A61P39/02 ,  B01J20/22 ,  C01B31/18

CPC classification number: A61K47/40 ,  A61K31/714 ,  A61K31/724 ,  A61K47/6951 ,  B01J20/22 ,  B01J20/223 ,  B01J20/262 ,  B01J2220/44 ,  B82Y5/00 ,  C08B37/0012 ,  C08B37/0015 ,  C08L5/16

Abstract: The present invention provides a carbon monoxide removal agent that can be easily administered to a patient by injection or orally. The carbon monoxide removal agent of the present invention contains, as an active ingredient, an inclusion complex in which a cyclodextrin dimer represented by chemical formula (1) below includes a water-soluble metalloporphyrin. (In the formula, m represents either of number 1 or 2 and n represents any of number 1, 2, or 3.)

Abstract translation: 本发明提供可以通过注射或口服容易地给予患者的一氧化碳去除剂。 作为活性成分，本发明的一氧化碳除去剂含有下述化学式（1）表示的环糊精二聚体包含水溶性金属卟啉的包合络合物。 （式中，m表示数字1或2，n表示数字1,2或3）

公开(公告)号：EP2253435A1

公开(公告)日：2010-11-24

申请号：EP09716035.2

申请日：2009-02-25

Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM

Inventor： KAI, Yoshihiro ,  ADACHI, Tatsuya ,  OKUDAIRA, Yusuke

IPC: B25J19/06 ,  B25J19/00 ,  F16D51/12 ,  F16D65/22

CPC classification number: B25J19/063 ,  F16D51/18 ,  F16D63/006

Abstract: A robot safety device, which is provided between a drive shaft of a robot and an actuator for driving the drive shaft and prevents unexpected action to a user positioned around the robot, and in which such a possibility that a robot damages a person is detected and the detection is utilized as a trigger to quickly stop the driving force for the robot. The device is provided with a transmission part which transmits to the drive shaft an output from the actuator, an acceleration operation corresponding part which mechanically generates corresponding to the transmission accelerating operation of the transmission part caused by the actuator, regulation auxiliary force for regulating the operation of the transmission part caused by the output from the actuator, and a regulation part which is driven by the regulation auxiliary force generated by the accelerating operation corresponding part and regulates the operation of the transmission part.

Abstract translation: 一种机器人安全装置，其设置在机器人的驱动轴和用于驱动驱动轴的致动器之间，并且防止对位于机器人周围的用户的意外动作，并且检测到机器人损坏人的可能性; 该检测被用作快速停止机器人的驱动力的触发器。 该装置设置有传动部，该传动部将来自致动器的输出传递给驱动轴;对应于由致动器引起的变速部的变速器加速动作机械地产生的加速运转对应部;调节辅助力， 由由致动器的输出引起的变速部分和由加速运转对应部分产生的调节辅助力驱动的调节部分，并调节变速部分的运转。

公开(公告)号：EP2246842A1

公开(公告)日：2010-11-03

申请号：EP10161643.1

申请日：2010-04-30

Applicant: Funai Electric Advanced Applied Technology Research Institute Inc. ,  TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  Funai Electric Co., Ltd.

Inventor： Fukuoka, Toshimi ,  Weng, Wu ,  Higuchi, Tetsuya ,  Suzuki, Masao ,  Takano, Rikuo ,  Omodani, Makoto

IPC: G09G3/38

CPC classification number: G09G3/38 ,  G09G2300/06 ,  G09G2310/0256 ,  G09G2320/0209

Abstract: Disclosed is an electrochromic display device (100) comprising: a first and a second substrates (10,30); a first and a second electrodes (20,40); and an electrochromic composition layer (50), wherein the device is of a passive matrix drive where a display and an erasion are performed by an energization in reverse directions between the electrodes, the first and the second electrodes respectively comprise a plurality of electrodes, a pixel (60) is formed where the electrodes are in a grade separated crossing, and the display is performed by voltage application processing where: (i) the first electrode is set as negative, and the second electrode is set as positive, to apply a voltage of a first potential difference, immediately followed by (ii) the first electrode being set as positive, and the second electrode being set as negative, to apply a voltage of a second potential difference equal to or more than the first potential difference.

公开(公告)号：EP2075019A1

公开(公告)日：2009-07-01

申请号：EP07829816.3

申请日：2007-10-15

Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM

Inventor： SAITO, Akira ,  YOKOYAMA, Tun Aung

IPC: A61M1/18

CPC classification number: A61M1/3472 ,  A61M1/3489 ,  C12M25/10 ,  C12M29/16 ,  C12N5/0686 ,  C12N2501/727 ,  C12N2533/30

Abstract: The present invention provides a bioartificial renal tubule that forms an artificial kidney together with a bioartificial glomerulus suitable for continuous hemofiltration. The bioartificial renal tubule includes an artificial membrane having an inner surface coated with renal tubular epithelial cells and a vessel containing the artificial membrane. The cells are prevented by the use of a MEK inhibitor from being stratified and therefore form a confluent monolayer on the artificial membrane. The renal tubular epithelial cells are characterized in that the contact inhibition thereof is maintained by the use of the MEK inhibitor. The MEK inhibitor is preferably U0126. The attachment of cells capable of reproducing the function of a kidney allows dialysis to be continuously performed for 24 hours with high efficiency and also allows the ability of a renal tubule to reabsorb useful substances to be achieved.

Abstract translation: 本发明提供一种生物人造肾小管，其与适于连续血液滤过的生物人造肾小球一起形成人造肾。 生物人造肾小管包括具有涂覆有肾小管上皮细胞的内表面的人造膜和含有人造膜的容器。 通过使用MEK抑制剂来分层细胞，从而在人造膜上形成汇合单层。 肾小管上皮细胞的特征在于通过使用MEK抑制剂维持其接触抑制。 MEK抑制剂优选为U0126。 能够再现肾功能的细胞的附着使得透析能够以高效率连续进行24小时，并且还允许肾小管重吸收有用物质的能力。