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    IMPLANTABLE MEDICAL DEVICE
    59.
    发明授权
    IMPLANTABLE MEDICAL DEVICE 失效
    可植入医疗设备

    公开(公告)号：EP0906129B1

    公开(公告)日：2002-08-28

    申请号：EP97928775.2

    申请日：1997-06-04

    申请人： Cook Incorporated

    发明人： FISCHER, Frank, J., Jr.

    IPC分类号： A61L29/00 ,  A61M25/00 ,  A61L31/00 ,  A61L33/00

    CPC分类号： A61M25/0045 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61K51/1282 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/42 ,  A61L2300/45 ,  A61M31/002 ,  C08L83/04

    摘要： An implantable medical device (10) such as a catheter with a pharmacologically active ingredient layered between outer and inner elongated member tubes (11 and 13) for minimizing the risk of infection or other physiological afflictions associated with the implantation thereof. The outer and inner elongated member tubes include a base material mixed with a bioactive material including, for example, one and/or the other of rifampin and minocycline. An itermediate tube or layer (18) is positioned between and in communication with the outer and inner elongated member tubes (11 and 13). The intermediate tube or layer also includes a base material of, for example, silicone with a pharmacologically active ingredient mixed therein. The slower diffusion rate minocycline is included as or part of the bioactive material in the base material of the outer and inner elongated member tubes. The pharmacologically active ingredient or bioactive material such as a mixture of rifampin and minocycline is included in the base material of the intermediate tube or layer, which permeates through the inner and outer member tubes and diffuses therefrom or therethrough for treating tissues surrounding the catheter concomitantly.