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    Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors
    4.
    发明公开
    Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors 失效
    组合物和装置用于软骨组织的体内包括具有骨诱导和/或软骨诱导因子纳米胶囊修

    公开(公告)号：EP0896825A1

    公开(公告)日：1999-02-17

    申请号：EP97810567.4

    申请日：1997-08-14

    申请人： SULZER INNOTEC AG

    发明人： Atkinson, Brent A. ,  Ranieri, John ,  Bittmann, Pedro ,  Whitney, Marsha Lynn ,  Benedict, James John ,  Chickering, Donald

    IPC分类号： A61L27/00 ,  A61K9/51

    CPC分类号： A61K9/5153 ,  A61B17/06166 ,  A61F2/30756 ,  A61F2002/2817 ,  A61F2002/30036 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2250/0035 ,  A61F2310/00365 ,  A61L27/227 ,  A61L27/24 ,  A61L27/26 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/30 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2430/06 ,  B82Y5/00 ,  Y10S977/91 ,  Y10S977/914 ,  C08L89/06 ,  C08L5/08

    摘要： The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days. The nanospheres are composed of e.g. ((D,L)-lactic acid / glycolic acid)-copolymer (PLGA). The loaded nanospheres are e.g. made by phase inversion. The composition is advantageously utilized as a device comprising any biodegradable matrix in which the nanospheres loaded with the factor combination is contained.

    摘要翻译： 如所描述的所述组合物提供用于体内软骨修复。 它的各种因素的天然来源的骨诱导和/或软骨诱导混合物（例如，来自骨衍生的）的基本上besteht或寻求与纳米球递送系统相结合。混合物的合成模拟物的因素的优选的混合物是从骨中分离的因素的结合 称为BP和由波塞尔和笃（WO13767分之95）中所述。 纳米球递送系统定义为直径小于1000纳米（其中大部分粒子优选为纳米400之间200到），其中的因素纳米球组合被包封聚合物颗粒的纳米球besteht。 纳米球装载有的在0.001的重量比因素混合物到17％（重量/重量），优选为1〜4％（重量/重量），并且具有以10初始爆破配合的释放曲线的20％ 在第一个24小时的总负载，并在至少七个继天每天至少0.1长时间释放。 纳米球是由E. G.的 （（D，L） - 乳酸/乙醇酸）共聚物（PLGA）。 加载的纳米球例如是 通过相转化制备。 该组合物被有利地用作包括其中装有因子组合的纳米球被包含任何可生物降解的基质的装置。